Brief review: Angiotensin converting enzyme inhibitors and angioedema: anesthetic implications

Sarkar, P.; Nicholson, Grainne; Hall, George

doi:10.1007/bf03022528

Cited by 47 publications

(38 citation statements)

References 99 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1,2 It is estimated that there are over 100,000 emergency department visits for angioedema in the United States each year 3 and ACEI angioedema accounts for 20-40% of these visits. [4][5][6] ACEI associated angioedema is the most common cause of angioedema seen in the emergency department 4 and a very frequent cause seen in our experience on the inpatient Allergy consult service. 7 Understanding the epidemiology and risk factors for ACEI associated angioedema is important to managing any patient being prescribed an ACEI because it is associated with a high morbidity (intubation, intensive care unit admissions, and hospitalizations) and fatal reactions have been reported.…”

Section: Introductionmentioning

confidence: 78%

Epidemiology of ACE Inhibitor Angioedema Utilizing a Large Electronic Health Record

Banerji

Blumenthal

Lai

et al. 2017

The Journal of Allergy and Clinical Immunology: In Practice

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 78%

Epidemiology of ACE Inhibitor Angioedema Utilizing a Large Electronic Health Record

Banerji

Blumenthal

Lai

et al. 2017

The Journal of Allergy and Clinical Immunology: In Practice

View full text Add to dashboard Cite

show abstract

“…This case illustrates angioedema localized to the tongue, with no severe respiratory distress requiring intubation or tracheostomy. However, airway obstruction in angioedema is found in 15-20% of cases [17]. Deaths from asphyxia secondary to airway obstruction have been reported [18].…”

Section: Discussionmentioning

confidence: 97%

Enapranil-Induced Angioedema in a 2-Year-Old Infant: Case Report

Koraichi¹,

Tadili²,

Benjelloun³

et al. 2011

Cardiovasc Toxicol

View full text Add to dashboard Cite

“…Inhibition of ACE or its receptor is widely used in pharmacotherapy -more than 40 million people are using drugs of this type for the treatment of cardiovascular diseases and/or diabetes [25,26] . In this context the association between the 'low-activity' ACE genotype and suicide raises concern that in susceptible individuals such therapy might be dangerous.…”

Section: Discussionmentioning

confidence: 99%

Angiotensin-Converting Enzyme Polymorphism and Completed Suicide: An Association in Caucasians and Evidence for a Link with a Method of Self-Injury

Fudalej¹,

Fudalej

Kostrzewa

et al. 2009

Neuropsychobiology

View full text Add to dashboard Cite

Background/Aims: An association between the II genotype of the angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) polymorphism and suicide was found among Japanese men. Our purpose was to replicate this finding in Caucasians and explore other putative genotypic associations among suicides. Methods: The ACE genotypes were studied by a 2-stage PCR method in 150 completed suicides and 165 age- and sex-matched controls. Results: We found an increase in the frequency of the ACEI allele among male victims of suicide compared to male controls (odds ratio, OR = 1.69, p < 0.006), female suicides (OR = 2.01, p = 0.006) and pooled controls (OR = 1.77, p = 0.001). Analysis of genotype distribution showed that the codominant model had the best fit (p = 0.7) whereas the recessive model could be rejected (p = 0.04). Among males we found an association between the number of the ACE I allele and the method of suicide: OR = 17.98, p_corrected = 0.00003, for jumping from a height; OR = 0.36, p_corrected = 0.048, for hanging. We also observed a trend for a negative effect of the number of copies of the ACE I allele on prevalence of depression (OR = 0.36, p = 0.013) and a trend for an effect on age at death (p = 0.021). Conclusions: Our results suggest that low ACE activity associated with the I allele is a risk factor for suicide, especially in a subset of males. This may be of concern given the widespread use of drugs lowering ACE activity.

show abstract

Brief review: Angiotensin converting enzyme inhibitors and angioedema: anesthetic implications

Cited by 47 publications

References 99 publications

Epidemiology of ACE Inhibitor Angioedema Utilizing a Large Electronic Health Record

Epidemiology of ACE Inhibitor Angioedema Utilizing a Large Electronic Health Record

Enapranil-Induced Angioedema in a 2-Year-Old Infant: Case Report

Angiotensin-Converting Enzyme Polymorphism and Completed Suicide: An Association in Caucasians and Evidence for a Link with a Method of Self-Injury

Contact Info

Product

Resources

About