Bridging endometrial receptivity and implantation: network of hormones, cytokines, and growth factors

Singh, Mohan B.; Chaudhry, Parvesh; Asselin, Éric

doi:10.1530/joe-10-0461

Cited by 275 publications

(225 citation statements)

References 102 publications

(94 reference statements)

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“…The activin pathway has been postulated to be involved in regulation of multiple reproductive processes including ovarian follicular development (Knight et al 2012), luteinisation of the follicular cells (Myers et al 2008, Kayani et al 2009), early embryo development (Rajput et al 2013) and uterine function during implantation of the conceptus (Singh et al 2011). As a member of the transforming growth factor beta superfamily of growth factors, activin forms from the dimerisation of two b-subunits of inhibin (INHB), with different combinations forming functionally different isoforms (Knight 1996, Mellor et al 2003.…”

Section: Introductionmentioning

confidence: 99%

Activin A and follistatin during the oestrous cycle and early pregnancy in ewes

O’Connell¹,

McNatty²,

Hurst³

et al. 2016

Journal of Endocrinology

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The activin pathway has been postulated to be involved in regulation of multiple reproductive processes important for survival of the conceptus. These processes include luteinisation of the follicular cells and thus function of the corpus luteum, early embryo development and uterine function including implantation of the conceptus. Therefore, the aim of the current study was to determine whether the concentrations of activin A and follistatin (FST), an activin-binding protein, differed between ewes with a lifetime history of enhanced or reduced embryonic survival (ES). The mRNAs encoding FST and activin A (inhibin beta A subunit; INHBA) were present in the uterus and abundant in the uterine luminal or glandular epithelia by day 18 of gestation. A peak of activin A was observed in the systemic circulation around the time of oestrus, and activin A concentrations were elevated in animals with reduced ES during the oestrous cycle and early gestation. Concentrations of activin A in uterine fluid were approximately twofold greater on day 16 of gestation in ewes with reduced ES compared to those with enhanced ES. No consistent differences in FST were observed between these groups. Treatment of luteinising ovine granulosa cells with activin A in vitro suppressed progesterone secretion providing evidence of a potential pathway whereby increased concentrations of activin A may decrease ES.

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Section: Introductionmentioning

confidence: 99%

Activin A and follistatin during the oestrous cycle and early pregnancy in ewes

O’Connell¹,

McNatty²,

Hurst³

et al. 2016

Journal of Endocrinology

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“…Różnice w ekspresji TGF-β1, 2 i 3 w endometrium zależne od fazy cyklu płciowego oraz gatunku zwierząt wykazano w licznych badaniach (6,25,58). Jak wskazują dostępne dane literaturowe, w błonie śluzowej macicy kobiet szereg białek należących do rodziny TGF-β podlega zróżnicowanej ekspresji w różnych fazach cyklu miesiączkowego.…”

Section: Artykuł Przeglądowy Reviewunclassified

“…Jak wskazują dostępne dane literaturowe, w błonie śluzowej macicy kobiet szereg białek należących do rodziny TGF-β podlega zróżnicowanej ekspresji w różnych fazach cyklu miesiączkowego. Głównym miejscem występowania TGF-β2 jest zrąb endometrium, podczas gdy TGF-β1 i TGF-β3 zlokalizowano zarówno w komórkach nabłonka, jak i zrębie błony śluzowej macicy (25,58). TGF-β1 stwierdzano przede wszystkim w gruczołach endometrialnych oraz w płynie macicy (49).…”

Section: Artykuł Przeglądowy Reviewunclassified

“…TGF-β1 stwierdzano przede wszystkim w gruczołach endometrialnych oraz w płynie macicy (49). Cyklicznych zmian w poziomie ekspresji nie odnotowano w odniesieniu do cytokin TGF-β1 i TGF-β2, odwrotnie niż w przypadku TGF-β3, który jest syntetyzowany przez gruczoły endometrium w późnej fazie wydzielniczej cyklu płciowego (30,58).…”

Section: Artykuł Przeglądowy Reviewunclassified

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Relevant aspects of the influence of chosen growth factors on the activity of the female reproductive system

Woźna¹,

Rybska²,

Swierczewska³

et al. 2017

Medycyna Weterynaryjna

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*) Projekt został sfinansowany ze środków Narodowego Centrum Nauki przyznanych na podstawie decyzji DEC-2013/09/N/NZ5/0183. Woźna M., Rybska M., Świerczewska M., Jaśkowski J. M.Relevant aspects of the influence of chosen growth factors on the activity of the female reproductive system Summary The endometrium of the uterus is a highly dynamic structure in terms of its changes during the various stages of the sexual cycle. These changes are the result of cyclical fluctuations in the concentrations of steroid hormones and local factors of an auto -and paracrine -nature. This condition indicates that the causes of degenerative processes of the uterus must be sought not only in disorders of the hormonal profile and bacterial infections but also disorders at the molecular level. Factors that may play a key role in the formation and development of various pathologies of the female reproductive system include growth factors and their receptors (growth factors -GFs). Discussing these growth factors in the work may provide useful molecular markers that identify pathological conditions of the endometrium. Subject to expression in the endometrium, they are involved in the regulation of cell proliferation, migration and secretion of the glandular epithelium, they also regulate physiological and pathological angiogenesis, revealing strong pro-inflammatory effects. In this research, the authors present an overview of current scientific reports indicating that changes in the expression of studied factors, and thus disturbances in their effects, may constitute one of the causes of pathogenesis within the uterus in many animal species.

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“…The nature and roles of the key molecules involved in blastocyst implantation is still under investigation [1][2][3][4][5]. Decidualization is the progressive remodeling of the endometrium that provides a receptive environment referred to as the "window of implantation" [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Human endometrial milk fat globule-epidermal growth factor 8 (MFGE8) is up regulated by estradiol at the transcriptional level, and its secretion via microvesicles is stimulated by human chorionic gonadotropin (hCG)

Sarhan¹,

Bocca²,

Yu³

et al. 2013

Cell Signal Traffic

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Objective: We have recently showed that MFGE8, a novel epithelial cell protein in the human endometrium, upregulated during the window of implantation. We hypothesized that MFGE8 may act as a key modulator of endometrial remodeling and trophoblast invasion. The aims of this study were (i) to investigate the in vitro regulation of human endometrial epithelial cells MFGE8 transcription, translation, and secretion by sex steroids and hCG; and (ii) to examine the possibility of MFGE8 secretion via microvesicles. Design: Experimental in vitro study using Ishikawa cells. Setting: University center. Interventions: Treatment with estradiol (E2), progesterone (P4), and human chorionic gonatropin (hCG). Main outcome measures: MFGE8 mRNA and protein expression, and identification of secreted microvesicles by mass spectrometry (MS) and immunoblotting. Results: E 2 , but not P4 or hCG, significantly upregulated MFGE8 mRNA expression. hCG significantly increased MFGE8 secretion. Microvesicels obtained after ultracentrifugation were visualized with atomic force microscopy ranging from ~100 to 200 nm. In addition to the expected 46 kD protein, the microvesicles contained a second form of secreted MFGE8 measuring ~30 kD which was confirmed by MS. Conclusions: We demonstrated (i) dual effects of E 2 and hCG on the regulation of MFGE8, and (ii) MFGE8 protein secretion in association with microvesicles. MFGE8 has the potential to modulate endometrial function and implantation via exocrine and/ or paracrine-autocrine effects. To the best of our knowledge, this is the first demonstration of microvesicular secretion of any regulatory protein by endometrial epithelial cells, providing initial evidence suggestive of microvesicular participation in cellular trafficking information in the non-pregnant and pregnant endometrium.

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Bridging endometrial receptivity and implantation: network of hormones, cytokines, and growth factors

Cited by 275 publications

References 102 publications

Activin A and follistatin during the oestrous cycle and early pregnancy in ewes

Activin A and follistatin during the oestrous cycle and early pregnancy in ewes

Relevant aspects of the influence of chosen growth factors on the activity of the female reproductive system

Human endometrial milk fat globule-epidermal growth factor 8 (MFGE8) is up regulated by estradiol at the transcriptional level, and its secretion via microvesicles is stimulated by human chorionic gonadotropin (hCG)

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