2006
DOI: 10.1186/1471-2407-6-96
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Abstract: Background: Genomic DNA copy number aberrations are frequent in solid tumors, although the underlying causes of chromosomal instability in tumors remain obscure. Genes likely to have genomic instability phenotypes when mutated (e.g. those involved in mitosis, replication, repair, and telomeres) are rarely mutated in chromosomally unstable sporadic tumors, even though such mutations are associated with some heritable cancer prone syndromes.

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Cited by 256 publications
(302 citation statements)
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“…34,40 Association of Genomic Regions with Clinical-Pathological Parameters Amplification of 8p and 11q are most often observed in ER positive tumors whereas amplification of 17q occurs in both ER-positive and ER-negative tumors. 41,42 In our study, EGFR (7p), CCNE1 (19q) and HER2 (17q) were associated with a negative ER status, whereas FGFR1 (8p), ADAM9 (8p), IKBKB (8p) and TOP2A (17q) were associated with a positive ER status of the tumor. Contrary to the study of Holst et al, 17 we did not observe a significant association between ESR1 amplification and ER protein overexpression (73% of tumors with ESR1 amplification were ER-positive compared with 69% of tumors without ESR1 amplification).…”
Section: Discussionmentioning
confidence: 47%
“…34,40 Association of Genomic Regions with Clinical-Pathological Parameters Amplification of 8p and 11q are most often observed in ER positive tumors whereas amplification of 17q occurs in both ER-positive and ER-negative tumors. 41,42 In our study, EGFR (7p), CCNE1 (19q) and HER2 (17q) were associated with a negative ER status, whereas FGFR1 (8p), ADAM9 (8p), IKBKB (8p) and TOP2A (17q) were associated with a positive ER status of the tumor. Contrary to the study of Holst et al, 17 we did not observe a significant association between ESR1 amplification and ER protein overexpression (73% of tumors with ESR1 amplification were ER-positive compared with 69% of tumors without ESR1 amplification).…”
Section: Discussionmentioning
confidence: 47%
“…Studies by our group and others show that pRb gene expression levels are lowest in basal-like tumors (2,40,52,53). Tumors with loss of functional pRb signaling have a higher frequency of chromosome copy number alterations than do tumors with aberrations of other members of the p16/pRb pathway (54).…”
Section: Deregulated P16/prb Signaling: Phenotypic Consequences For Dcismentioning
confidence: 74%
“…4a). Loss of 16q is one of the most common observed copy number aberrations in breast cancer [23] and has previously been associated with good prognosis in three studies using LOH [24], gene expression profiling [25], or aCGH [26].…”
Section: Regions Of Differential Expressionmentioning
confidence: 99%