Breast <scp>PET</scp>/<scp>MRI</scp> Hybrid Imaging and Targeted Tracers

Romeo, Valeria; Helbich, Thomas H.; Pinker, Katja

doi:10.1002/jmri.28431

Cited by 6 publications

(8 citation statements)

References 84 publications

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“…In addition, quantitative measurements from 18F-FDG PET are influenced by breast density and, possibly, age [ 27 , 28 ]. Thus, an alternative tracer, such as 18F-FEC, is desirable [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…Our results, though, also indicate that the accuracy of 18F-FEC is lower than the accuracy of contrast-enhanced MRI alone. The clinical role of PET tracers is most relevant in the staging and phenotyping of cancer aggressiveness [ 29 ]. Our results indicate that 18-FEC uptake correlates with lesion characteristics and suggest that it could provide clinically relevant additional information on cancer aggressiveness and lymph node status.…”

Section: Discussionmentioning

confidence: 99%

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Prospective validation of 18F-Fluoroethylcholine as a tracer in PET/MRI for the evaluation of breast lesions and prediction of lymph node status

et al. 2023

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Purpose To assess 18F-Fluoroethylcholine (18F-FEC) as a PET/MRI tracer in the evaluation of breast lesions, breast cancer aggressiveness, and prediction of lymph node status. Materials and methods This prospective, monocentric study was approved by the ethics committee and patients gave written, informed consent. This clinical trial was registered in the EudraCT database (Number 2017-003089-29). Women who presented with suspicious breast lesions were included. Histopathology was used as reference standard. Simultaneous 18F-FEC PET/MRI of the breast was performed in a prone position with a dedicated breast coil. MRI was performed using a standard protocol before and after contrast agent administration. A simultaneous read by nuclear medicine physicians and radiologists collected the imaging data of MRI-detected lesions, including the maximum standardized 18F-FEC-uptake value of breast lesions (SUVmaxT) and axillary lymph nodes (SUVmaxLN). Differences in SUVmax were evaluated with the Mann–Whitney U test. To calculate diagnostic performance, the area under the receiver operating characteristics curve (ROC) was used. Results There were 101 patients (mean age 52.3 years, standard deviation 12.0) with 117 breast lesions included (30 benign, 7 ductal carcinomas in situ, 80 invasive carcinomas). 18F-FEC was well tolerated by all patients. The ROC to distinguish benign from malignant breast lesions was 0.846. SUVmaxT was higher if lesions were malignant (p < 0.001), had a higher proliferation rate (p = 0.011), and were HER2-positive (p = 0.041). SUVmaxLN was higher in metastatic lymph nodes, with an ROC of 0.761 for SUVmaxT and of 0.793 for SUVmaxLN. Conclusion Simultaneous 18F-FEC PET/MRI is safe and has the potential to be used for the evaluation of breast cancer aggressiveness, and prediction of lymph node status.

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“…In addition, quantitative measurements from 18F-FDG PET are influenced by breast density and, possibly, age [ 27 , 28 ]. Thus, an alternative tracer, such as 18F-FEC, is desirable [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prospective validation of 18F-Fluoroethylcholine as a tracer in PET/MRI for the evaluation of breast lesions and prediction of lymph node status

et al. 2023

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“…10,[27][28][29][30] Angiogenesis and metabolism are the 2 hallmarks of cancer that can be evaluated by contrast-enhanced MRI and 18 F-FDG PET. 31 Proliferation can be assessed by DWI, 20 and the increase in metabolism that precedes proliferation can be used as an early marker of tumor growth.…”

Section: Subtype Angiogenesis Metabolism and Tumor Microenvironment R...mentioning

confidence: 99%

“…19 Multiparametric imaging involves combining any of the imagederived information mentioned previoulsy. 20 Attempts are being made to identify the optimal combination of multiple parameters, with the use of radiomics and deep learning as auxiliary tools. With the abundant information provided by multiparametric imaging, researchers are trying to identify more complex characteristics of breast cancer, including proliferation, vascularity, subtype, and even the immune environment, all of which are essential aspects of personalized breast cancer treatment.…”

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confidence: 99%

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Multiparametric Approach to Breast Cancer With Emphasis on Magnetic Resonance Imaging in the Era of Personalized Breast Cancer Treatment

Kataoka,

Iima,

Miyake

et al. 2023

Invest Radiol

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A multiparametric approach to breast cancer imaging offers the advantage of integrating the diverse contributions of various parameters. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is the most important MRI sequence for breast imaging. The vascularity and permeability of lesions can be estimated through the use of semiquantitative and quantitative parameters. The increased use of ultrafast DCE-MRI has facilitated the introduction of novel kinetic parameters. In addition to DCE-MRI, diffusion-weighted imaging provides information associated with tumor cell density, with advanced diffusion-weighted imaging techniques such as intravoxel incoherent motion, diffusion kurtosis imaging, and time-dependent diffusion MRI opening up new horizons in microscale tissue evaluation. Furthermore, T2-weighted imaging plays a key role in measuring the degree of tumor aggressiveness, which may be related to the tumor microenvironment. Magnetic resonance imaging is, however, not the only imaging modality providing semiquantitative and quantitative parameters from breast tumors. Breast positron emission tomography demonstrates superior spatial resolution to whole-body positron emission tomography and allows comparable delineation of breast cancer to MRI, as well as providing metabolic information, which often precedes vascular and morphological changes occurring in response to treatment. The integration of these imaging-derived factors is accomplished through multiparametric imaging. In this article, we explore the relationship among the key imaging parameters, breast cancer diagnosis, and histological characteristics, providing a technical and theoretical background for these parameters. Furthermore, we review the recent studies on the application of multiparametric imaging to breast cancer and the significance of the key imaging parameters.

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Multiparametric MRI and Radiomics to Predict HER2-Low Cancer: The Potential Therapeutic Impact

Kataoka

Honda

2023

Radiology

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Breast PET/MRI Hybrid Imaging and Targeted Tracers

Cited by 6 publications

References 84 publications

Prospective validation of 18F-Fluoroethylcholine as a tracer in PET/MRI for the evaluation of breast lesions and prediction of lymph node status

Prospective validation of 18F-Fluoroethylcholine as a tracer in PET/MRI for the evaluation of breast lesions and prediction of lymph node status

Multiparametric Approach to Breast Cancer With Emphasis on Magnetic Resonance Imaging in the Era of Personalized Breast Cancer Treatment

Multiparametric MRI and Radiomics to Predict HER2-Low Cancer: The Potential Therapeutic Impact

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