Breast sarcoma. A case report and review of literature

Li, Nuria; Cusidó, Maite; Navarro, Beatriz; Tresserra, F.; Baulies, Sonia; Ara, Carmen; Fábregas, R.

doi:10.1016/j.ijscr.2016.04.033

Cited by 19 publications

(27 citation statements)

References 5 publications

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“…On one hand, primary sarcomas can take various histological types that often require IHC to differentiate [9], and secondary sarcomas often present as angiosarcoma, especially after radiation therapy of another tumor [10]. In our patient, it was important to do IHC to confirm the diagnosis as it is uncommon to be considered a different diagnosis in a previous carcinoma patient who never received radiotherapy.…”

Section: Discussionmentioning

confidence: 97%

Primary Stromal Breast Sarcoma with Concomitant Contralateral Carcinoma: A Rare Case from Syria

Khudari

Homsi

zohaily

et al. 2019

Case Reports in Oncological Medicine

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Bilateral breast cancers are rare cases encountered and are usually the same type in both sides. Only very few cases were reported to have different histological types of neoplasia involving sarcoma. Moreover, sarcomas rarely originate from the breast as a primary lesion whereas the common presentation is having angiosarcoma following radiotherapy. In this report, we present a rare case of a Syrian 43-year-old woman having two distinct primary lesions in the breasts: invasive ductal carcinoma and contralateral stromal sarcoma.

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Section: Discussionmentioning

confidence: 97%

Primary Stromal Breast Sarcoma with Concomitant Contralateral Carcinoma: A Rare Case from Syria

Khudari

Homsi

zohaily

et al. 2019

Case Reports in Oncological Medicine

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“…In the case of suspicion of a breast AS, the best imaging test is MRI [9,30,31]. The final diagnosis of AS is made based on the results of pathological testing [32,33].…”

Section: Discussionmentioning

confidence: 99%

Angiosarcoma — a malignant neoplasm secondary to radiotherapy for breast cancer in a female patient following breast-conserving treatment — a case report

Kidrycka¹,

Burzyńska-Śliwowska²,

Maksim³

et al. 2019

Oncol Clin Pract

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Angiosarcoma is a rare malignant neoplasm, accounting for 1-2% of all sarcomas. The main cause of developing secondary angiosarcoma is radiotherapy. We analysed the case of a 52-year-old woman with breast cancer, who had undergone breast-conserving therapy. Four years after finishing treatment, she was diagnosed with secondary angiosarcoma in the irradiated area. The patient underwent a mastectomy. The disease relapsed six months after the operation in form of local recurrence, as well as liver and lung metastases. The patient's condition gradually deteriorated despite treatment (chemotherapy and symptomatic management). The patient died due to cardiorespiratory failure nine months after the diagnosis of secondary malignancy.

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“…Moreover, undifferentiated pleomorphic sarcoma in the breast is an aggressive, fast-growing tumor with a high rate of local recurrence (44%) and distal metastases (42%) [ 1 ], but the therapeutic recommendations are difficult to establish with evolving techniques and limited patient numbers. The most important treatment element in maximizing disease-free survival and overall survival is complete surgical removal of the tumor [ 32 – 36 ], although a standard surgical practice is still not known, owing to the rarity of this tumor. In the absence of prospective and randomized trials, response rates to systemic therapies remain poor [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

The Role of Adjuvant Radiotherapy for a Case of Primary Breast Sarcoma: A Plan Comparison between Three Modern Techniques and a Review of the Literature

Cozzolino

Oliviero

D’Andrea

et al. 2018

Case Reports in Medicine

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A 65-year-old woman, affected by a malignant fibrous histiocytoma (undifferentiated pleomorphic sarcoma) of the left breast, presented to our department to receive the postoperative radiotherapy. In the absence of prospective and randomized trials and investigations on breast sarcoma irradiation in literature, due to the rarity of this pathology, the role of adjuvant radiotherapy remains unclear. To identify the best radiotherapy technique for this patient, three methods were compared: 3D conformal radiotherapy (3D-CRT), intensity-modulated radiation therapy (IMRT), and volumetric arc therapy (VMAT) or RapidArc® (RA). 50 Gy was prescribed to the chest wall and 66 Gy to the tumor bed. Three plans were designed, and target coverage, organs-at-risk sparing, and treatment efficiency were compared. IMRT and RA improved both target coverage and dose uniformity/homogeneity. Planning objective for the lung is always satisfied comparing the different techniques, but the volume receiving 20 Gy drops to 17% by RA compared to 3D-CRT. The heart volume receiving 30 Gy was 10% by IMRT, against 13% and 16% by RA and 3D-CRT. The monitor unit (MU) required by 3D-CRT was 527 MU, followed by RA and IMRT. Treatment time was similar with 3D-CRT and RA but doubled using IMRT. Although all three radiotherapy techniques offered a satisfactory solution, RA and IMRT offer some improvement on target coverage, dose homogeneity, and conformity for this particular case of breast sarcoma.

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Breast sarcoma. A case report and review of literature

Cited by 19 publications

References 5 publications

Primary Stromal Breast Sarcoma with Concomitant Contralateral Carcinoma: A Rare Case from Syria

Primary Stromal Breast Sarcoma with Concomitant Contralateral Carcinoma: A Rare Case from Syria

Angiosarcoma — a malignant neoplasm secondary to radiotherapy for breast cancer in a female patient following breast-conserving treatment — a case report

The Role of Adjuvant Radiotherapy for a Case of Primary Breast Sarcoma: A Plan Comparison between Three Modern Techniques and a Review of the Literature

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