Breast cancer outcomes in a population with high prevalence of obesity

Herlevic, Vincent; Mowad, Ronald; Miller, J. Karen; Darensburg, Nicholas A.; Li, Benjamin D.L.; Kim, Roger H.

doi:10.1016/j.jss.2015.03.088

Cited by 19 publications

(14 citation statements)

References 21 publications

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“…Nonetheless, little evidence has thus far been produced to show an association between GHRL polymorphisms and survival in breast cancer patients. However, GHRL polymorphisms have been associated with obesity (3) and recent studies have associated obesity with decreased survival in breast cancer patients (30, 31), particularly in Hispanics with morbid obesity (18) but these results are far from conclusive and are contradicted by other studies (32). …”

Section: Discussionmentioning

confidence: 99%

Energy homeostasis genes and survival after breast cancer diagnosis: the Breast Cancer Health Disparities Study

Pellatt

Lundgreen

Wolff

et al. 2015

Cancer Causes Control

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Purpose The leptin-signaling pathway and other genes involved with energy homeostasis (EH), have been examined in relation to breast cancer risk as well as to obesity. We test the hypothesis that genetic variation in EH genes influences survival after diagnosis with breast cancer and that body mass index (BMI) will modify that risk. Methods We evaluated associations between 10 energy homeostasis genes and survival among 1186 non-Hispanic white (NHW) and 1155 Hispanic/Native American women diagnosed with breast cancer. Percent Native American (NA) ancestry was determined from 104 Ancestry Informative Markers. Adaptive rank truncation product (ARTP) was used to determine gene and pathway significance. Results The overall EH pathway was marginally significant for all-cause mortality among women with low NA ancestry (PARTP = 0.057). Within the pathway, ghrelin (GHRL) and leptin receptor (LEPR) were significantly associated with all-cause mortality (PARTP = 0.035 and 0.007, respectively). The EH pathway was significantly associated with breast cancer-specific mortality among women with low NA ancestry (PARTP = 0.038). Three genes, cholecystokinin (CCK), GHRL, and LEPR were significantly associated with breast cancer-specific mortality among women with low NA ancestry (PARTP = 0.046, 0.015, and 0.046, respectively) while neuropeptide Y (NPY) was significantly associated with breast cancer-specific mortality among women with higher NA ancestry (PARTP = 0.038). BMI did not modify these associations. Conclusions Our data support our hypothesis that certain EH genes influence survival after diagnosis with breast cancer; associations appear to be most important among women with low NA ancestry.

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Section: Discussionmentioning

confidence: 99%

Energy homeostasis genes and survival after breast cancer diagnosis: the Breast Cancer Health Disparities Study

Pellatt

Lundgreen

Wolff

et al. 2015

Cancer Causes Control

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“…[1] Therefore, surgical care should be an integral part of the healthcare plan and policy of any nation state. In most low-and middle-income countries (LMICs) data on the surgical prevalence of disease have been mainly derived from hospital-based studies [2][3][4]. Such data are potentially deficient in several aspects.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of surgically correctable conditions among children in a mixed urban-rural community in Nigeria using the SOSAS survey tool: Implications for paediatric surgical capacity-building

et al. 2019

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Background In many low-and middle-income countries, data on the prevalence of surgical diseases have been derived primarily from hospital-based studies, which may lead to an underestimation of disease burden within the community. Community-based prevalence studies may provide better estimates of surgical need to enable proper resource allocation and prioritization of needs. This study aims to assess the prevalence of common surgical conditions among children in a diverse rural and urban population in Nigeria. Methods Descriptive cross-sectional, community-based study to determine the prevalence of congenital and acquired surgical conditions among children in a diverse rural-urban area of

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“…Obesity is an established independent prognostic factor for breast cancer patients (21, 22); however, several reports disagree with this notion (43, 44). In order to clarify whether this is the case in cohort at a national level, we evaluated overall survival (OS) and disease free survival (DFS) in high and low BMI patients in TCGA.…”

Section: Resultsmentioning

confidence: 99%

Doxorubicin effect is enhanced by sphingosine-1-phosphate signaling antagonist in breast cancer

Katsuta

Yan

Nagahashi

et al. 2017

Journal of Surgical Research

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Background Doxorubicin is one of the most commonly used chemotherapeutic drugs for breast cancer; however, its use is limited by drug resistance and side-effects. We hypothesized that adding FTY720, a sphingosine-1- phosphate (S1P) receptor functional antagonist, to doxorubicin would potentiate its effects by suppression of drug-induced inflammation. Materials and Methods The Cancer Genome Atlas (TCGA), GEO datasets, and NCI-60 panel were used for gene expressions and gene set enrichment analysis (GSEA). E0771 syngeneic mammary tumor cells were used. OB/OB mice fed with western high fat diet were used as an obesity model. Results STAT3 expression was significantly increased after doxorubicin treatment in human breast cancer that implicates that doxorubicin evokes inflammation. Expression of sphingosine kinase 1 (SphK1), the enzyme that produces S1P and links inflammation and cancer, tended to be higher in doxorubicin resistant human cancer and cell lines. In a murine breast cancer model, SphK1, S1P receptor 1 (S1PR1), IL6 and STAT3 were over-expressed in the doxorubicin treated group, whereas all of them were significantly suppressed with addition of FTY720. Combination therapy synergistically suppressed cancer growth both in vitro and in vivo. Furthermore, combination therapy showed higher efficacy in an obesity breast cancer model, where high body mass index (BMI) demonstrated trends toward worse disease free and overall survival, and high serum S1P levels in human patients and volunteers. Conclusions We found that FTY720 enhanced the efficacy of doxorubicin by suppression of drug-induced inflammation, and combination therapy showed stronger effect in obesity-related breast cancer.

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Breast cancer outcomes in a population with high prevalence of obesity

Cited by 19 publications

References 21 publications

Energy homeostasis genes and survival after breast cancer diagnosis: the Breast Cancer Health Disparities Study

Energy homeostasis genes and survival after breast cancer diagnosis: the Breast Cancer Health Disparities Study

Prevalence of surgically correctable conditions among children in a mixed urban-rural community in Nigeria using the SOSAS survey tool: Implications for paediatric surgical capacity-building

Doxorubicin effect is enhanced by sphingosine-1-phosphate signaling antagonist in breast cancer

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