Breast cancer in western part of Libya: Pattern and management (2003-2018)

Gusbi, Eman; Elgriw, Nada; Zalmat, Shiaa; Alemam, Hafsa A; Khalil, Sumia; Gusbi, Mokhtar; Elhamadi, Miluda; Benyasaad, Taha; Enattah, Nabil; Elzagheid, Adam

doi:10.4103/ljms.ljms_5_20

Cited by 5 publications

(3 citation statements)

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“…Late presentation with advanced disease was common among patients in this study with Stage III B accounting for nearly half of the cases at presentation (22,24). Though Shepherd (2004) reported that 96.9% of women in Sierra Leone had some knowledge of breast cancer and were aware that early presentation is key for improved clinical outcome, yet most patients with breast cancer presented with locally advanced disease at our clinic.…”

Section: Discussionmentioning

confidence: 72%

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The pattern of presentation, management and outcome of breast cancer patients at a tertiary health facility in Sierra Leone

-John,

Bah,

Smalle

et al. 2024

Preprint

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Background Breast cancer is the leading cause of cancer among women globally and the most common cancer amongst women in Sierra Leone. The aim of this study was to evaluate the patterns of clinical presentation, management and outcome among breast cancer patients who presented at the Connaught Teaching Hospital Complex in Sierra Leone. Method A retrospective, cross-sectional study was conducted at the specialist outpatient clinic at the Connaught Hospital. The medical records of 253 breast cancer patients were selected through a convenience sampling based on completeness of their data from 2018 to 2021. Patient's socio-demographic, obstetrics-gynaecological history, clinic-pathological characteristics, treatment modalities and outcomes were analysed by SPSS version 24. Results Of the 253 breast cancer patients, 246 (97.2%) were female and the mean age of the patients was 47±14 years. The mean age at menarche was 12±3 years and 35 (13.8%) of patients had a family history of breast cancer. The left breast 130 (51.2%) was the most commonly affected; about 119 (47%) of patients presented with stage III B and 35 (13.8%) with metastasis at presentation. With regards to treatment modalities, a combination of surgery, chemotherapy, and hormonal were provided to the patients, with 25.2 (48%) mastectomies, 98 (20.5%) hormonal therapy, 35 (7.3%) palliative care and about 8 (15.2%) refused treatment. The outcomes of breast cancer patients showed the highest mortality was in 2019, 19 (32.8%) and the least was in 2018, 10 (27.8%). Conclusion Our study showed that over half of our patients presented in advanced stage and mastectomy was the most common modality of treatment. There is a need to promote public health awareness on early presentation to improve patient’s outcome.

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Section: Discussionmentioning

confidence: 72%

“…About 62.9% of patients, were married and 37.7% were involved in some form of trading activity for their main source of income. The left was the most commonly affected breast (n = 130, 51.2%) and bilateral breast cancer was reported in 2% of patients (22)(23)(24).…”

Section: Discussionmentioning

confidence: 99%

The pattern of presentation, management and outcome of breast cancer patients at a tertiary health facility in Sierra Leone

-John,

Bah,

Smalle

et al. 2024

Preprint

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“…In the present study, a Ki-67 level of > 20% was recorded in 23.9 % of the cases while, in the western part of Libya, the Ki-67 level >15 was 19.1% (30), ( 31), (32) . This reflects a higher frequency of Luminal A phenotype (86.6%) and less rates of Luminal B (65.4%), Triple Negative (36.5%) and HER2 overexpression (25.2%) (33) . Molecular subtype analyses revealed that Luminal A was the commonest molecular subtype (61.1%), followed by Luminal B, Triple Negative and HER2 Luminal B subtype had a poorer prognosis than Luminal A, tending to spread more aggressively, suggesting the importance of anti-HER2 therapy.…”

Section: Discussionmentioning

confidence: 94%

A Histopathological Study of the Breast Cancer Cases Registered at Benghazi Medical Center from 2016 to 2018

Bilhassan,

Zoubi,

Attia

2023

sjuob

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Background: Breast cancer (BRC) is the second most common cancer in the world, the most frequent cancer among women, and the leading cause of cancer death in females worldwide. Aims to study the pattern of breast cancer in all the patients who were presented to the Oncology Department at Benghazi Medical Center (BMC) from various parts of eastern Libya from the 1st of January 2016 to the 31st of December 2018. Subjects and Methods: This is a retrospective, cross-sectional and histopathological study to determine the frequency of the (BRC) malignancy type, in addition to stages and age groups. The data was collected from the Oncology Department at Benghazi Medical Center which receives cancer patients from Benghazi and the whole eastern part of Libya. Data was also collected from the Pathology Department at the Faculty of Medicine, University of Benghazi and Alnon, a private laboratory. There were 515 registered patients with breast cancer including demographic and clinic-pathological data. The data was analyzed using the SPSS Program Version 20. Results: Out of 515 breast cancer patients registered at the Oncology Department (BMC), geographically 66% were from Benghazi, followed by Albaida at 9.1%. Conclusion: The majority of cases were between 46 and 56 years old. Invasive ductal carcinoma was diagnosed among most of the cases, (Grade II and stage III. Most of the breast cancer cases collected from BMC were from Benghazi, frequency is higher among the age range (46-56) and most cases were Stage III, and grade II. Invasive ductal carcinoma is the most predominant histopathological type. Most cases were HER2 negative, ER positive and PR positive, and most cases had Ki-67 levels (21- 40%).

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