Breast cancer and fat grafting: efficacy, safety and complications—a systematic review

Decker, Marjolein De; Schrijver, L. De; Thiessen, Filip; Tondu, Thierry; Goethem, M. Van; Tjalma, Wiebren A.A.

doi:10.1016/j.ejogrb.2016.10.032

Cited by 58 publications

(41 citation statements)

References 53 publications

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“…Despite fears about the risks of malignant transformation that may be associated with the use of autologous ADSC, very low frequencies of loco-regional tumour recurrences have been reported in post-surgery breast cancer reconstruction. [ 83 , 84 ] This contradicts the experimental results in which the oncogenic potential of the ADSC secretoma is demonstrated, and also, expresses the great complexity and heterogeneity of the factors that can promote or antagonise the malignant transformation when ADSC is transplanted [ 85 , 86 ].…”

Section: Adipose Tissue Stem Cells In Regenerative Medicinementioning

confidence: 98%

Adipose tissue stem cells in regenerative medicine

Miana

González

2018

ecancer

125

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Adipose tissue-derived stem cells (ADSCs) are mesenchymal cells with the capacity for self-renewal and multipotential differentiation. This multipotentiality allows them to become adipocytes, chondrocytes, myocytes, osteoblasts and neurocytes among other cell lineages. Stem cells and, in particular, adipose tissue-derived cells, play a key role in reconstructive or tissue engineering medicine as they have already proven effective in developing new treatments. The purpose of this work is to review the applications of ADSCs in various areas of regenerative medicine, as well as some of the risks associated with treatment with ADSCs in neoplastic disease.

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Section: Adipose Tissue Stem Cells In Regenerative Medicinementioning

confidence: 98%

Adipose tissue stem cells in regenerative medicine

Miana

González

2018

ecancer

125

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“…Several metaanalyses and systematic reviews have unanimously concluded that autologous fat transfer does not lead to an increased rate of locoregional breast cancer recurrence. [65][66][67][68][69][70] However, as mentioned previously, a higher rate of biopsies exists with patients who have undergone fat grafting to the breasts compared with the general population, as fat necrosis may be difficult to distinguish radiographically from breast cancer. 21,22 That is, to date there is a substantial amount of evidence that fat grafting remains a safe and highly effective option for cosmetic breast surgery in patients with a history of breast cancer.…”

Section: Oncological Safetymentioning

confidence: 99%

Application of Fat Grafting in Cosmetic Breast Surgery

Davis

Perdanasari

Abu‐Ghname

et al. 2020

Seminars in Plastic Surgery

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The role of fat grafting to the breasts has evolved in the recent past, gaining several new applications within both reconstructive and aesthetic surgery. Initially used for reconstructive purposes to fill lumpectomy defects or to correct residual contour deformities after breast reconstruction, it has since made its way into cosmetic breast surgery and has grown to encompass a wide variety of new indications. Fat grafting in aesthetic breast surgery may be performed as a form of primary autologous breast augmentation or as an adjunct to implant-based breast augmentation to disguise implant edges. It may also be used to provide added volume after explant surgery or to provide improvements in breast contour alongside mastopexy techniques. In this article, we will review the current applications of fat grafting in aesthetic breast surgery and provide an up-to-date summary of its reported outcomes, safety, and complications.

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“…38 Additional studies have all concluded no increased risk of recurrent or new cancer with fat grafting. [39][40][41] Patient-reported outcome studies have shown improved patient satisfaction with secondary fat grafting revision procedures to improve contours. 35,36…”

Section: Secondary Fat Graftingmentioning

confidence: 99%

Latest Trends in Subpectoral Breast Reconstruction

Winocour

Lemaine³

2019

Seminars in Plastic Surgery

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There has been a shift in recent years toward a growing popularity of implant-based breast reconstruction, especially in the setting of increased frequency of concurrent contralateral prophylactic mastectomy. Advancements in implant safety and technology have also allowed for an expanding implant reconstruction practice across the country. The traditional approach is immediate two-stage implant reconstruction with placement of a tissue expander within a subpectoral pocket. The introduction of acellular dermal matrix has revolutionized implant-based breast reconstruction, allowing surgeons the opportunity to minimize morbidity while maximizing aesthetic outcomes. There have also been advances in the management of postoperative pain control as well as secondary revision surgery.

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Breast cancer and fat grafting: efficacy, safety and complications—a systematic review

Cited by 58 publications

References 53 publications

Adipose tissue stem cells in regenerative medicine

Adipose tissue stem cells in regenerative medicine

Application of Fat Grafting in Cosmetic Breast Surgery

Latest Trends in Subpectoral Breast Reconstruction

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