Breast arterial calcification and risk of carotid atherosclerosis: Focusing on the preferentially affected layer of the vessel wall

Sedighi, Nahid; Radmard, Amir Reza; Radmehr, Ali; Hashemi, Pari; Hajizadeh, Abdolmahmoud; Taheri, Amir

doi:10.1016/j.ejrad.2010.04.007

Cited by 39 publications

(39 citation statements)

References 19 publications

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“…Mönckeberg's medial calcific sclerosis has also been described in patients with diabetes and end-stage renal failure (13,14). Although intimal arterial calcification is a component of atherosclerotic disease, medial calcification results from a process that belongs to aging, which does not have much clinical significance (2,7,14).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, C-IMT measurement is suggested as a useful tool to detect early atherosclerotic changes (5,6,16,17). Intimal changes reflect coronary artery disease (7). Although numerous previous studies have analyzed the correlation between BAC and cardiovascular risk, the correlation between BAC and intima-media thickness has been rarely investigated (7,8).…”

Section: Discussionmentioning

confidence: 99%

“…Intimal changes reflect coronary artery disease (7). Although numerous previous studies have analyzed the correlation between BAC and cardiovascular risk, the correlation between BAC and intima-media thickness has been rarely investigated (7,8). Concordant with our findings, C-IMT was significantly higher in patients with BAC than in patients without (8).…”

Section: Discussionmentioning

confidence: 99%

“…Arterial calcifications are marker of atherosclerotic disease and therefore an indicator to predict cardiovascular future (4). Although there are many studies examining various aspects of the relationship between cardiovascular disease and BAC in the literature, there is limited number of studies available investigating the association between C-IMT and BAC (7,8). Carotid artery hemodynamic parameters have not been studied in these studies.…”

Section: Discussionmentioning

confidence: 99%

“…Radiologically observed calcifications in the coronary arteries, thoracic aorta, and abdominal aorta are used to correlate with the increased prevalence of coronary artery disease. Epidemiological studies also showed that BACs are correlated with hypertension, diabetes, cardiovascular diseases, and cardiovascular mortality (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

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Breast arterial calcifications and carotid intima-media thickness and haemodynamics: Is there any association?

Büyükkaya

Büyükkaya²,

Altunkaş³

et al. 2014

Anadolu Kardiyol Derg

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Objective: In this study, we aimed to research the relation between breast arterial calcifications (BACs) detected on mammography and two well-known markers of cardiovascular diseases-carotid artery intima-media thickness (C-IMT) and haemodynamics parameters like carotid peak-systolic velocity (PSV), end-diastolic velocity (EDV) and resistive index (RI). Methods: The study group consisted of 50 consecutive BAC (+) women and the control group consisted of 55 BAC (-) women. In all participants, BAC was diagnosed using mammography and C-IMT was measured using B-mode and Doppler ultrasonography. BAC was defined as two linear calcification depositions in a conical periphery or as calcific rings at the mammographic evaluation. Doppler spectrum samples were obtained from 2 cm proximal to the main carotid artery bifurcation. Results: Postmenopausal female patients ranging in age from 40 to 86 included in this study. When the groups were adjusted for age, a statistically significant difference was found between mean C-IMT of BAC (+) and BAC (-) groups (0.81±0.2 vs. 0.69±0.2 mm; p<0.001). No significant differences were observed between BAC (+) and BAC (-) groups in terms of PSV, EDV, RI. Conclusion: The findings of the present study suggest that BAC, diagnosed by mammography, is independently associated with C-IMT. C-IMT measurement is suggested as a useful tool to detect early atherosclerotic changes. However, haemodynamic variables (PSV, EDV, RI) were not statistically different between the BAC (+) and BAC (-) groups. Prospective larger cohort studies are needed to further elucidate whether BAC is an independent risk factor for cardiovascular disease. (Anadolu Kardiyol Derg 2014; 14: 378-82)

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Breast arterial calcifications and carotid intima-media thickness and haemodynamics: Is there any association?

Büyükkaya

Büyükkaya²,

Altunkaş³

et al. 2014

Anadolu Kardiyol Derg

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Relationship between breast arterial calcifications detected on mammography and brachial artery intima-media thickness

Erdoğmuş

Büyükkaya

et al. 2013

Wien Klin Wochenschr

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In conclusion, even though the relationship between B-IMT and BAC was significant, like the relationship between C-IMT and BAC, significant age difference between BAC (+) and BAC (-) groups and no significant relationship between BAC and time after menopause, after adjustment for age, suggest a strong association between BAC and age rather than AS. This can be elucidated by pathological correlation studies in larger series of subjects.

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The association between breast arterial calcification and atherosclerotic cardiovascular disease in an Australian population-based breast cancer case–control study

et al. 2023

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Purpose Atherosclerotic cardiovascular disease (ASCVD) is a major cause of morbidity and mortality. Breast arterial calcification (BAC) on mammograms is not associated with breast cancer risk. However, there is increasing evidence supporting its association with cardiovascular disease (CVD). This study examines the association between BAC and ASCVD and their risk factors within an Australian population-based breast cancer study. Materials and methods Data from the controls who participated in the breast cancer environment and employment study (BCEES) were linked with the Western Australian Department of Health Hospital Morbidity database and Mortality Registry to obtain ASCVD outcomes and related risk factor data. Mammograms from participants with no prior history of ASCVD were assessed for BAC by a radiologist. Cox proportional hazards regression was used to examine the association between BAC and later occurrence of an ASCVD event. Logistic regression was used to investigate the factors associated with BAC. Results A total of 1020 women with a mean age of 60 (sd = 7.0 years) were included and BAC found in 184 (18.0%). Eighty (7.8%) of the 1020 participants developed ASCVD, with an average time to event of 6.2 years (sd = 4.6) from baseline. In univariate analysis, participants with BAC were more likely to have an ASCVD event (HR = 1.96 95% CI 1.29–2.99). However, after adjusting for other risk factors, this association attenuated (HR = 1.37 95% CI 0.88–2.14). Increasing age (OR = 1.15, 95% CI 1.12–1.19) and parity (pLRT < 0.001) were associated with BAC. Conclusion BAC is associated with increased ASCVD risk, but this is not independent of cardiovascular risk factors.

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Breast arterial calcification and risk of carotid atherosclerosis: Focusing on the preferentially affected layer of the vessel wall

Cited by 39 publications

References 19 publications

Breast arterial calcifications and carotid intima-media thickness and haemodynamics: Is there any association?

Breast arterial calcifications and carotid intima-media thickness and haemodynamics: Is there any association?

Relationship between breast arterial calcifications detected on mammography and brachial artery intima-media thickness

The association between breast arterial calcification and atherosclerotic cardiovascular disease in an Australian population-based breast cancer case–control study

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