Breakthrough Pain in Patients Referred to Pain Clinics: The Italian Pain Network Retrospective Study

Gatti, Antonio; Mediati, Rocco Domenico; Reale, Carlo; Cuomo, Arturo; Vellucci, Renato; Russo, Gennaro; Costantini, A; Canneti, Alessandro; Luzi, Marta; Mammucari, Massimo; Sabato, Alessandro

doi:10.1007/s12325-012-0022-z

Cited by 18 publications

(16 citation statements)

References 28 publications

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“…Nasal administration of fentanyl provided faster analgesia relative to other fentanyl products [30]. Patient-reported satisfaction with pain treatment is an important outcome measure when assessing both background pain and BTP [8].…”

Section: Discussionmentioning

confidence: 99%

Breakthrough Cancer Pain: Preliminary Data of The Italian Oncologic Pain Multisetting Multicentric Survey (IOPS-MS)

et al. 2016

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IntroductionAn ongoing national multicenter survey [Italian Oncologic Pain multiSetting Multicentric Survey (IOPS-MS)] is evaluating the characteristics of breakthrough cancer pain (BTP) in different clinical settings. Preliminary data from the first 1500 cancer patients with BTP enrolled in this study are presented here.MethodsThirty-two clinical centers are involved in the survey. A diagnosis of BTP was performed by a standard algorithm. Epidemiological data, Karnofsky index, stage of disease, presence and sites of metastases, ongoing oncologic treatment, and characteristics of background pain and BTP and their treatments were recorded. Background pain and BTP intensity were measured. Patients were also questioned about BTP predictability, BTP onset (≤10 or >10 min), BTP duration, background and BTP medications and their doses, time to meaningful pain relief after BTP medication, and satisfaction with BTP medication. The occurrence of adverse reactions was also assessed, as well as mucosal toxicity.ResultsBackground pain was well controlled with opioid treatment (numerical rating scale 3.0 ± 1.1). Patients reported 2.5 ± 1.6 BTP episodes/day with a mean intensity of 7.5 ± 1.4 and duration of 43 ± 40 min; 977 patients (65.1%) reported non-predictable BTP, and 1076 patients (71.7%) reported a rapid onset of BTP (≤10 min). Higher patient satisfaction was reported by patients treated with fast onset opioids.ConclusionsThese preliminary data underline that the standard algorithm used is a valid tool for a proper diagnosis of BTP in cancer patients. Moreover, rapid relief of pain is crucial for patients’ satisfaction. The final IOPS-MS data are necessary to understand relationships between BTP characteristics and other clinical variables in oncologic patients.FundingMolteni Farmaceutici, Italy.

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Section: Discussionmentioning

confidence: 99%

Breakthrough Cancer Pain: Preliminary Data of The Italian Oncologic Pain Multisetting Multicentric Survey (IOPS-MS)

et al. 2016

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“…It is introduced by Yang and Gandomi in 2012 and it is inspired form bats behaviour in foraging for food. This algorithm is quite similar to PSO and it is consist of velocity and position equations [ 118 , 119 ]. Since this algorithm is inspired by bats, it considers the echolocation capability that bats have and also take advantage of a frequency equation.…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Review of Swarm Optimization Algorithms

2015

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Many swarm optimization algorithms have been introduced since the early 60’s, Evolutionary Programming to the most recent, Grey Wolf Optimization. All of these algorithms have demonstrated their potential to solve many optimization problems. This paper provides an in-depth survey of well-known optimization algorithms. Selected algorithms are briefly explained and compared with each other comprehensively through experiments conducted using thirty well-known benchmark functions. Their advantages and disadvantages are also discussed. A number of statistical tests are then carried out to determine the significant performances. The results indicate the overall advantage of Differential Evolution (DE) and is closely followed by Particle Swarm Optimization (PSO), compared with other considered approaches.

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“…[76] In a retrospective study of consecutive pain patients at a single center, 56.4% of patients overall reported severe BTP; in cancer pain patients, 70.3% reported severe BTP. [77] These numbers may actually under-report the phenomenon, in that the definition of BTP has recently been challenged to include "BTP-like flares" in patients who do not have chronic background pain controlled by opioids. [78] This expanded definition would increase the numbers, possibly by as much as 10%.…”

Section: The Role Of Ir Oxycodonementioning

confidence: 99%

Maximizing value in opioid utilization: Is oxycodone immediate release a good option for pain management?

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et al. 2015

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ÖzetAğrı tedavisine modern yaklaşım sürecin her yönüyle optimal düzeye getirilmesinden geçer. Bu SummaryThe modern approach to the management of pain involves optimizing all aspects of the process. This includes utilization of pharmacologic and non-pharmacologic modalities, consideration of patient characteristics, proper matching of the physiology of the pain with the analgesic' s mechanism of action (pharmacodynamics, PD), and the onset and duration of action (pharmacokinetics, PK). No single agent or formulation satisfies all of the requirements for all patients. Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) are effective options for inflammatory pain and, as is acetaminophen, for mild pain. Specialized agents are helpful for particular pains, such as for migraine headache. Opioids remain the standard option for severe pain. Although they are generally a safe and effective option, opioids can produce dose-limiting adverse effects and have abuse potential. The goal of pain therapy is thus to achieve the maximum pain relief with the least amount of opioid exposure. Against this background of measured approach to the use of analgesics, an immediate release (IR) oral formulation of the established opioid oxycodone has been developed to provide rapid onset of action and rate of titration, both of which could maximize temporal matching of dose with pain level and reduce total exposure to drug. This article considers the option of an immediate release (IR) oral formulation for the management of pain.

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Breakthrough Pain in Patients Referred to Pain Clinics: The Italian Pain Network Retrospective Study

Cited by 18 publications

References 28 publications

Breakthrough Cancer Pain: Preliminary Data of The Italian Oncologic Pain Multisetting Multicentric Survey (IOPS-MS)

Breakthrough Cancer Pain: Preliminary Data of The Italian Oncologic Pain Multisetting Multicentric Survey (IOPS-MS)

A Comprehensive Review of Swarm Optimization Algorithms

Maximizing value in opioid utilization: Is oxycodone immediate release a good option for pain management?

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