Breakthrough in the Treatment of Warts?

Gibbs, Sam

doi:10.1001/archderm.142.6.767

Cited by 7 publications

(4 citation statements)

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“…No adverse effects were reported . However, the study design and results received rather harsh criticism . HAMLET treatment was not compared to placebo‐ or conventional treatment because all patients received HAMLET treatment during the second phase of the trial.…”

Section: Hamlet and Bamlet Complexes Are Not Specific For Cancer Cellsmentioning

confidence: 99%

Protein–fatty acid complexes: biochemistry, biophysics and function

2013

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Thirteen years ago, α‐lactalbumin (α‐LA) was first reported to form a complex with oleic acid (OA). This complex, called HAMLET (human α‐lactalbumin made lethal to tumour cells), was found to be cytotoxic to cancer cells. In HAMLET, α‐LA assumes a partially unfolded conformation and can bind OA in various stoichiometries. Subsequently, different groups have been able to prepare HAMLET‐like cytotoxic complexes in different ways, which all involve the destabilization of α‐LA, and a number of different proteins have been able to form similar complexes. This suggests that the ability to form stable complexes with lipids may be a generic feature of the polypeptide chain, although the precise structural and functional details may vary from protein to protein. We review the biophysical and biochemical properties of this class of complexes, focusing on different methods of preparation, complex structure and the role of the protein and the lipid within these complexes. The cellular effects of these complexes are multifaceted and depend on the cell types. There are strong indications that OA has an essential role, whereas the protein component, rather than having a toxic effect on its own, functions as a vehicle for transporting the toxic OA to the cells and keeping the OA in solution. Fatty acids alone can affect numerous cellular signalling and metabolic pathways, in addition to playing important roles in immune responses and inflammatory processes. Further studies will aim to determine how the molecular properties of the different protein–lipid complexes correlate with their biological efficacy.

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Section: Hamlet and Bamlet Complexes Are Not Specific For Cancer Cellsmentioning

confidence: 99%

Protein–fatty acid complexes: biochemistry, biophysics and function

2013

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“…Microbial cultures [132] and transgenic animals [133] are used for large-scale production of the human variant of α-lactoalbumin. HAMLET has been used successfully in oncology: instilled in situ before resection of tumors in the bladder, improving the prognosis of this type of cancer [134]; in topical application in papillomas, achieving complete remission of lesions in more than 90% of treated patients and without significant side effects [135].…”

Section: α-Lactoalbuminmentioning

confidence: 99%

“…Complete remission of treated injuries in more than 90% of patients treated, without significant secondary effects. [135] Bovine lactoferrin Infant formula…”

Section: Nutritional Supplementmentioning

confidence: 99%

Breast Milk: A Source of Functional Compounds with Potential Application in Nutrition and Therapy

et al. 2021

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Breast milk is an unbeatable food that covers all the nutritional requirements of an infant in its different stages of growth up to six months after birth. In addition, breastfeeding benefits both maternal and child health. Increasing knowledge has been acquired regarding the composition of breast milk. Epidemiological studies and epigenetics allow us to understand the possible lifelong effects of breastfeeding. In this review we have compiled some of the components with clear functional activity that are present in human milk and the processes through which they promote infant development and maturation as well as modulate immunity. Milk fat globule membrane, proteins, oligosaccharides, growth factors, milk exosomes, or microorganisms are functional components to use in infant formulas, any other food products, nutritional supplements, nutraceuticals, or even for the development of new clinical therapies. The clinical evaluation of these compounds and their commercial exploitation are limited by the difficulty of isolating and producing them on an adequate scale. In this work we focus on the compounds produced using milk components from other species such as bovine, transgenic cattle capable of expressing components of human breast milk or microbial culture engineering.

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“…137 This result was sustained for 2 years after treatment cessation in 83% of HAMLET-treated patients, a result that has been hailed as a breakthrough in the treatment of human skin papillomas. 138 Methods for the large-scale production of HAMLET may include the expression of recombinant proteins in microorganisms 139 or transgenic cattle with scale-appropriate isolation systems. 140 Thus, HAMLET represents a novel antitumor therapy -derived from the study of milk -with remarkable clinical potential.…”

Section: Applications Of Human A-lactalbumin Made Lethal To Tumor Cellsmentioning

confidence: 99%

Clinical applications of bioactive milk components

Hill

Newburg

2015

Nutrition Reviews

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Milk represents a unique resource for translational medicine: It contains a rich pool of biologically active molecules with demonstrated clinical benefits. The ongoing characterization of the mechanistic process through which milk components promote development and immunity has revealed numerous milk-derived compounds with potential applications as clinical therapies in infectious and inflammatory disease, cancer, and other conditions. Lactoferrin is an effective antimicrobial and antiviral agent in high-risk patient populations and a potentially potent adjuvant to chemotherapy in lung cancer. Enteric nutrition formulas supplemented with transforming growth factor b, a milk cytokine, have been shown to promote remission in pediatric Crohn's disease. A number of milk glycans, including human milk oligosaccharides, show promise in preclinical studies as antimicrobial and antiinflammatory agents. While active preclinical investigations of human milk may soon result in large-scale production of human milk molecules, bovine milk components in many instances represent a practical source of bioactive milk compounds for use in clinical trials. This review summarizes current efforts to translate the compounds derived from human and bovine milk into effective clinical therapies. These efforts suggest a common pathway for the translation of milk-derived compounds into clinical applications.

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Breakthrough in the Treatment of Warts?

Cited by 7 publications

References 0 publications

Protein–fatty acid complexes: biochemistry, biophysics and function

Protein–fatty acid complexes: biochemistry, biophysics and function

Breast Milk: A Source of Functional Compounds with Potential Application in Nutrition and Therapy

Clinical applications of bioactive milk components

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