In this paper, we revisit brane inflation models with the WMAP five-year results.The WMAP five-year data favor a red-tilted power spectrum of primordial fluctuations at the level of two standard deviations, which is the same as the WMAP three-year result qualitatively, but quantitatively the spectral index is slightly greater than the three-year value. This result can bring impacts on brane inflation models.According to the WMAP five-year data, we find that the KKLMMT model can survive at the level of one standard deviation, and the fine-tuning of the parameter β can be alleviated to a certain extent at the level of two standard deviations.