Branched-chain amino acid supplementation and exercise-induced muscle damage in exercise recovery: A meta-analysis of randomized clinical trials

Rahimi, Mohammad; Shab‐Bidar, Sakineh; Mollahosseini, Mehdi; Djafarian, Kurosh

doi:10.1016/j.nut.2017.05.005

Cited by 55 publications

(47 citation statements)

References 29 publications

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“…Accumulating data suggest that BCAA supplementation before exercise may exert positive effects of BCAA on muscle soreness and low-to-moderate exercise-induced damage in some population groups [67,68], but it remains controversial and unclear due to the small amount of studies included in systematic reviews and meta-analysis. A recent meta-analysis including eight studies with a relatively small number of participants (ranges between 12–28 subjects included in each) indicated that use of BCAAs might be better than passive recovery after various exercise types in athletes [69].…”

Section: Protein and Amino Acid Supplements Targeted For Better Atmentioning

confidence: 99%

Protein Supplements and Their Relation with Nutrition, Microbiota Composition and Health: Is More Protein Always Better for Sportspeople?

et al. 2019

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Sports nutrition products are developed and targeted mainly for athletes to improve their nutrient intake, performance, and muscle growth. The fastest growing consumer groups for these products are recreational sportspeople and lifestyle users. Although athletes may have elevated physiological protein requirements and they may benefit from dietary supplements, the evidence regarding the role of dietary protein and supplements in the nutrition of recreational sportspeople and sedentary populations is somewhat complex and contradictory. In high-protein diets, more undigested protein-derived constituents end up in the large intestine compared to moderate or low-protein diets, and hence, more bacterial amino acid metabolism takes place in the colon, having both positive and negative systemic and metabolic effects on the host. The aim of the present review is to summarize the impact of the high-protein products and diets on nutrition and health, in sportspeople and in sedentary consumers. We are opening the debate about the current protein intake recommendations, with an emphasis on evidence-based effects on intestinal microbiota and personalized guidelines regarding protein and amino acid supplementation in sportspeople and lifestyle consumers.

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Section: Protein and Amino Acid Supplements Targeted For Better Atmentioning

confidence: 99%

Protein Supplements and Their Relation with Nutrition, Microbiota Composition and Health: Is More Protein Always Better for Sportspeople?

et al. 2019

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“…Branched chain amino acids (BCAA; Leucine, Isoleucine and Valine) have been proposed to maintain muscle mass or function in different conditions such as intensive physical activity [30,31] or in elderly patients [32]. BCAA are preferentially metabolized in skeletal muscle rather than in liver [33] and are involved in muscle mass development in mice [34].…”

Section: Introductionmentioning

confidence: 99%

Glutamine, but not Branched-Chain Amino Acids, Restores Intestinal Barrier Function during Activity-Based Anorexia

et al. 2019

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Background: During activity-based anorexia (ABA) in mice, enhanced paracellular permeability and reduced protein synthesis have been shown in the colon while the gut–brain axis has received increasing attention in the regulation of intestinal and mood disorders that frequently occur during anorexia nervosa, a severe eating disorder for which there is no specific treatment. In the present study, we assessed the effects of oral glutamine (Gln) or branched-chain amino acids (BCAA) supplementation during ABA to target intestinal functions, body composition and feeding behavior. Methods: C57BL/6 male mice were randomized in Control (CTRL) and ABA groups. After ABA induction, mice received, or not, either 1% Gln or 2.5% BCAA (Leu, Ile, Val) for one week in drinking water. Results: Neither Gln nor BCAA supplementation affected body weight and body composition, while only Gln supplementation slightly increased food intake. ABA mice exhibited increased paracellular permeability and reduced protein synthesis in the colonic mucosa. Oral Gln restored colonic paracellular permeability and protein synthesis and increased the mucin-2 mRNA level, whereas BCAA did not affect colonic parameters. Conclusion: In conclusion, oral Gln specifically improves colonic response during ABA. These data should be further confirmed in AN patients.

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“…BCAAs can significantly affect the stimulation of the mammalian target of the rapamycin (mTOR) kinase pathway and thus stimulate the synthesis of muscle proteins, as well as have anti-catabolic activity, related to inhibition of muscle protein proteolysis [1,2,3]. The above mechanisms may explain the observed effect of BCAA supply on the exercise-induced muscle damage, pain, fatigue or injury reduction, and the acceleration of fat-free mass or strength recovery [1,2,4,5]. Some additional benefits may also be observed for endurance (aerobic) exercise because BCAAs have ergogenic potential and may affect energy sources metabolism [6].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Beta-Alanine versus Alkaline Agent Supplementation Combined with Branched-Chain Amino Acids and Creatine Malate in Highly-Trained Sprinters and Endurance Athletes: A Randomized Double-Blind Crossover Study

Durkalec-Michalski

Kusy²,

Ciekot-Sołtysiak³

et al. 2019

Nutrients

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The study aimed to verify the effect of intra- (beta-alanine—BA) versus extra- (alkaline agents—ALK) cellular buffering agent supplementation, combined with customarily used branched-chain amino acids (BCAAs) and creatine malate (TCM) treatment in natural training conditions. Thirty-one elite athletes (11 sprinters and 20 endurance athletes) participated in the study. Eight-week randomized double-blind, crossover, combined supplementation with BA-ALKplaBCAA&TCM and ALK-BAplaBCAA&TCM was implemented. In the course of the experiment, body composition, aerobic capacity, and selected blood markers were assayed. After BA-ALKplaBCAA&TCM supplementation, total fat-free mass increased in sprinters (p = 0.009). No other differences were found in body composition, respiratory parameters, aerobic capacity, blood lactate concentration, and hematological indices after BA-ALKplaBCAA&TCM/ALK-BAplaBCAA&TCM supplementation. The maximum post-exercise blood ammonia (NH3) concentration decreased in both groups after BA-ALKplaBCAA&TCM supplementation (endurance, p = 0.002; sprint, p < 0.0001). Also, lower NH3 concentrations were observed in endurance athletes in the post-exercise recovery period. The results of our study indicate that combined BCAA, TCM, and BA supplementation is more effective than combined BCAA, TCM and ALK supplementation for an increase in fat-free mass and exercise adaptation, but not for aerobic capacity improvement. Besides, it seems that specific exercise stimuli and the training status are key factors affecting exercise performance, even in athletes using efficient supplementation.

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Branched-chain amino acid supplementation and exercise-induced muscle damage in exercise recovery: A meta-analysis of randomized clinical trials

Cited by 55 publications

References 29 publications

Protein Supplements and Their Relation with Nutrition, Microbiota Composition and Health: Is More Protein Always Better for Sportspeople?

Protein Supplements and Their Relation with Nutrition, Microbiota Composition and Health: Is More Protein Always Better for Sportspeople?

Glutamine, but not Branched-Chain Amino Acids, Restores Intestinal Barrier Function during Activity-Based Anorexia

The Effect of Beta-Alanine versus Alkaline Agent Supplementation Combined with Branched-Chain Amino Acids and Creatine Malate in Highly-Trained Sprinters and Endurance Athletes: A Randomized Double-Blind Crossover Study

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