Brain Vasotocin Pathways and the Control of Sexual Behaviors in the Bullfrog

Boyd, Sunny K.

doi:10.1016/s0361-9230(97)00213-x

Cited by 64 publications

(32 citation statements)

References 71 publications

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“…The bullfrog R. catesbeiana and the European green frog R. esculenta have long been used as models for studying the neuroendocrine and behavioral activities of the neurohypophysial hormones VT and MT (Warburg 1995, Boyd 1997. However, none of the receptors mediating the effects of VT and MT in these two advantageous amphibian species models has yet been characterized.…”

Section: Discussionmentioning

confidence: 99%

“…vocalization, male amplectic clasping behavior, and female sexual receptivity (Moore 1992, Boyd 1997. In this respect, the dense network of VT-containing fibers and the intense expression of VTR mRNA in the anterior preoptic area is of particular interest since this nucleus is clearly involved in the regulation of male calling behavior (Boyd 1997) and sexual activity (Moore et al 2000).…”

Section: Frog Vasotocin and Mesotocin Receptors · S Acharjee And Othementioning

confidence: 99%

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Molecular cloning, pharmacological characterization, and histochemical distribution of frog vasotocin and mesotocin receptors

Acharjee

do-Rego

et al. 2004

Journal of Molecular Endocrinology

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The neurohypophysial nonapeptides vasotocin (VT) and mesotocin (MT) are the amphibian counterparts of arginine vasopressin (AVP) and oxytocin (OT). We have here reported the cloning and functional characterization of the receptors for vasotocin (VTR) and mesotocin (MTR) in two species of frog, Rana catesbeiana and Rana esculenta. The frog VTR and MTR cDNAs encode proteins of 419 and 384 amino acids respectively. Frog VTR exhibits a high degree of sequence identity with the mammalian AVP-1a (V1a) receptor while the frog MTR possesses a high degree of sequence identity with the mammalian OT receptor. Activation of VTR induced both c-fos promoter-and cAMP-responsive element (CRE)-driven transcriptional activities, while activation of MTR induced c-fos promoter-driven transcriptional activity but failed to evoke CRE-driven transcriptional activity, suggesting differential G protein coupling between VTR and MTR. The VTR exhibited the highest sensitivity for VT followed by OT.AVP

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Section: Discussionmentioning

confidence: 99%

Section: Frog Vasotocin and Mesotocin Receptors · S Acharjee And Othementioning

confidence: 99%

Molecular cloning, pharmacological characterization, and histochemical distribution of frog vasotocin and mesotocin receptors

Acharjee

do-Rego

et al. 2004

Journal of Molecular Endocrinology

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“…Intracerebroventricular injection of VT also stimulates male courtship behavior, male amplectic behavior, and female sexual receptivity (Moore and Miller, 1983;Boyd, 1997;Klomberg and Marler, 2000;Thompson and Moore, 2000).…”

Section: Pharmacological Characterization Of Vt and Mt Receptorsmentioning

confidence: 99%

“…In amphibians, vasotocin (VT), the ortholog of mammalian VP, plays a crucial role in the control of various reproductive behaviors, such as vocal communication (Boyd, 1997), appetitive responses to olfactory and visual stimuli (Iwata et al, 2000;Thompson and Moore, 2000), courtship behavior (Iwata et al, 2000), clasping behavior Moore, 2000, 2003), and egg-laying behavior . In amphibians as in mammals, the mechanism of action of neurohypophysial peptides in modulating these behaviors is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Vasotocin and Mesotocin Stimulate the Biosynthesis of Neurosteroids in the Frog Brain

do-Rego

Acharjee

Seong

et al. 2006

Journal of Neuroscience

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The stimulatory effect of VT and MT on neurosteroid biosynthesis was mimicked by VP and OT, as well as by a selective V1b receptor agonist, whereas V2 and OT receptor agonists had no effect. VT-induced neurosteroid production was completely suppressed by selective V1a receptor antagonists and was not affected by V2 and OT receptor antagonists. Concurrently, the effect of MT on neurosteroidogenesis was markedly attenuated by selective OT and V1a receptor antagonists but not by a V2 antagonist. The present study provides the first evidence for a regulatory effect of VT and MT on neurosteroid biosynthesis. These data suggest that neurosteroids may mediate some of the behavioral actions of VT and MT.

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“…Neuropeptides of the vasopressin-oxytocin family (AVT-isotocin in fish) have been implicated in the modulation of a variety of reproductive-related behaviors, including vocalization (Moore, 1992;Boyd, 1997;Goodson and Bass, 2001). As in other vertebrate classes (Moore and Lowry, 1998), AVT-containing neurons are localized to the POA in midshipman fish (Foran and Bass, 1998;Goodson and Bass, 2000a).…”

Section: Arginine Vasotocinmentioning

confidence: 99%