Brain structure and connectivity in psoriasis and associations with depression and inflammation; findings from the UK biobank

Lada, Georgia; Talbot, Peter; Chinoy, Hector; Warren, Richard B.; McFarquhar, Martyn; Kleyn, C. Elise

doi:10.1016/j.bbih.2022.100565

Cited by 4 publications

(4 citation statements)

References 85 publications

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“…The precuneus constitutes an integral part of the DMN, participating in resting‐state self‐referential processing and episodic memory retrieval 51 . Previous studies have reported that patients with psoriasis tended to have thinner right precuneus than the controls 9,52 . A potential network containing the right precuneus was shown to be more interconnected as indicated on fMRI and diffusion tensor imaging in patients with psoriasis 53 .…”

Section: Discussionmentioning

confidence: 94%

Altered brain activity and cognitive impairment in patients with psoriasis

Yi,

Wang,

et al. 2023

Acad Dermatol Venereol

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BackgroundPatients with psoriasis may have cognitive impairment. However, there is limited information regarding intrinsic brain activity and cognitive function in patients with psoriasis.ObjectivesThis study aim to assess alterations of intrinsic brain activity and its association with cognitive function in patients with psoriasis.MethodsA total of 222 patients with psoriasis aged 18–70 years and 144 age and gender‐matched healthy controls (HCs) were enrolled into this study. All subjects underwent brain resting‐state functional magnetic resonance imaging (rs‐fMRI) and neuropsychological testing. The rs‐fMRI data were analysed for both intrinsic brain activity as indicated by amplitude of low‐frequency fluctuation (ALFF) and seed‐based functional connectivity (FC). Correlative analysis of brain activity with cognitive assessment was performed.ResultsCompared with the HCs, patients with psoriasis had worse cognitive performance in the Trail Making Test, Digit Span Test and Stroop Color‐Word Test (p < 0.05). Patients with psoriasis showed decreased ALFF in the left superior frontal gyrus, the left medial superior frontal gyrus and the right precuneus gyrus; as well as enhanced ALFF in the left paracentral lobule (pFWE < 0.05). Significant correlations were noted between the altered ALFF in the four brain regions and cognitive assessment (p < 0.05). Moreover, patients with psoriasis had increased FC between the four brain regions with altered ALFF (seeds) and the left prefrontal gyrus, the left anterior cingulate gyrus, left superior parietal lobule and default mode network (DMN) regions such as the right precuneus gyrus, left inferior parietal lobule, right angular gyrus and bilateral inferior temporal gyrus (pFWE < 0.05).ConclusionsPatients with psoriasis had altered brain activity and connectivity in the key brain areas within the DMN–prefrontal circuit. These brain changes may be the underlying neural correlates for cognitive functioning in patients with psoriasis.

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Section: Discussionmentioning

confidence: 94%

Altered brain activity and cognitive impairment in patients with psoriasis

Yi,

Wang,

et al. 2023

Acad Dermatol Venereol

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“…In an investigation using data from the UK biobank and MRI imaging, it was found that thickness in the right precuneus was increased in people with psoriasis compared to controls only when depression was present. 47 In another cohort of 29 people with psoriasis and depression and 24 healthy controls, functional magnetic resonance imaging scanning was performed in addition to severity measures of psoriasis (PASI) and a self-assessment of depression (SDS). 48 In comparison to healthy controls, people with psoriasis and depression demonstrated an increased fractional amplitude of low-frequency fluctuation in the left frontal middle brain area (Frontal_Mid_L) and increased functional connectivity between the right hypothalamus region and the right middle cingulum (Cingulum_Mid_R).…”

Section: Symptomsmentioning

confidence: 99%

“…The latest data come from brain structural studies comparing people with psoriasis and depression with respective controls. In an investigation using data from the UK biobank and MRI imaging, it was found that thickness in the right precuneus was increased in people with psoriasis compared to controls only when depression was present 47 . In another cohort of 29 people with psoriasis and depression and 24 healthy controls, functional magnetic resonance imaging scanning was performed in addition to severity measures of psoriasis (PASI) and a self‐assessment of depression (SDS) 48 .…”

Section: Risk Factors For Psoriasismentioning

confidence: 99%

Depression, a major comorbidity of psoriatic disease, is caused by metabolic inflammation

Mrowietz

Sümbül

Gerdes

2023

Acad Dermatol Venereol

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Psoriatic disease is a chronic, systemic immune‐mediated inflammatory disorder comprising three major domains, skin, vascular and bone/joint inflammation. It is known for a long time that psoriatic disease is associated with a number of conditions such as hypertension, dyslipidemia, diabetes (metabolic syndrome) and depression. Up to one out of five people with psoriasis show concomitant depression. In the past, this was attributed to psychological stress of suffering from a chronic condition that is often visible and itchy, leading to stigmatization and adding to a significant burden of disease. Recent data provide evidence that depression associated with psoriatic disease is linked to the specific inflammatory pattern with IL‐23, IL‐17 family cytokines, TNF, IL‐6 and IL‐8 causing neuroinflammation and subsequently depression or depressive behaviour and/or anxiety. Psoriatic disease shows a distinct pattern of immune cells (e.g. dendritic cells, Th17 cells, neutrophils), mediators (e.g. IL‐17A/F, IL‐23, TNF) and tissue‐related factors in all major domains that is different from other inflammatory dermatoses. There is a striking similarity between the inflammatory pattern in psoriatic disease and neuroinflammation that leads to depression. A number of risk factors have been identified in psoriatic disease, the most important of which are obesity and tobacco smoking. Obesity is known as a major risk factor for depression and anxiety due to its inflammatory signature. Apart from psychotherapy and anti‐depressive medication, targeted treatments for psoriasis, including TNF, IL‐17 and IL‐23 inhibitors, can improve depression/depressive symptoms. The review summarizes the current knowledge about depression as a comorbidity in psoriatic disease.

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“…From a study conducted by Mease and Menter [ 9 ], quality of life is negatively affected in the case of patients with extensive forms of psoriasis or in cases in which the lesions affect exposed areas of the body such as the hands, face, or delicate areas such as the genitals. Furthermore, variables such as skin pain and skin discomfort [ 10 , 11 , 12 ] negatively affect some vital functions such as sleep, mood, and, indeed, quality of life [ 13 , 14 , 15 ]. International research described how the most important comorbidities of psoriasis are mental disorders, especially depression and anxiety [ 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of Attachment Style and Temperament Traits on the Quality of Life of Patients with Psoriasis

Pistorio,

Moretta,

Musumeci

et al. 2024

Behavioral Sciences

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Background: Psoriasis is a chronic inflammatory skin disease with manifestations that go beyond the visual manifestation, and include psychological aspects. Some mental disorders or personality traits in psoriasis patients have also been highlighted, such as a negative or problematic attitude towards life, impulsive or avoidant behavior, and lower satisfaction with life. The aim of our cross-sectional study was to explore the associations between adult attachment, temperament, and quality of life of patients with psoriasis. Methods: A sample of 75 patients with psoriasis was evaluated with the Attachment Style Questionnaire (ASQ) to study adult attachment, the Temperament Evaluation of Memphis, Pisa, and San Diego Auto-questionnaire (TEMPS-A) to study temperament traits, and the Dermatology Life Quality Index (DLQI) to study the impact of dermatological diseases on patients’ lives. Results: Depressive, cyclothymic, and irritable temperaments were found to be significantly positively associated with a need for approval and preoccupation with relationships subscales of the ASQ. The severity of skin disease effect on the patient’s life was higher in women than in men. Moreover, a statistically significant effect of the need for approval subscale of the ASQ was found. The positive correlation between the severity of skin disease effect on the patient’s life with a need for approval was statistically significant and stronger in women than in men. Conclusions: A better understanding of the impact of mental comorbidities on psoriasis and vice versa places an ever-greater responsibility on dermatologists involved in the management of psoriasis to recognize these problems and collaborate with psychologists and psychiatrists to help these patients.

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Brain structure and connectivity in psoriasis and associations with depression and inflammation; findings from the UK biobank

Cited by 4 publications

References 85 publications

Altered brain activity and cognitive impairment in patients with psoriasis

Altered brain activity and cognitive impairment in patients with psoriasis

Depression, a major comorbidity of psoriatic disease, is caused by metabolic inflammation

Impact of Attachment Style and Temperament Traits on the Quality of Life of Patients with Psoriasis

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