Brain structural and functional connectivity in <scp>P</scp>arkinson's disease with freezing of gait

Canu, Elisa; Agosta, Federica; Sarasso, Elisabetta; Volontè, Maria Antonietta; Basaia, Silvia; Stojković, Tanja; Stefanova, Elka; Comi, Giancarlo; Falini, Andrea; Kostić, Vladimir; Gatti, Roberto; Filippi, Massimo

doi:10.1002/hbm.22994

Cited by 147 publications

(160 citation statements)

References 69 publications

Supporting

Mentioning

145

Contrasting

Order By: Relevance

“…In this study, we used the FreeSurfer implementation of surfacebased analysis and our results demonstrate that patients with FOG exhibited atrophy of the bilateral cingulate cortex (mostly in mid-anterior part), left supplementary motor area (SMA), and right frontal operculum. In summary, earlier publications reported rather complex pattern of functional and morphological changes [6][7][8][9][10][11]29 , suggesting a complex pathophysiological substrate of FOG. Whereas the automatic control of gait appears to be subserved by brainstem nuclei and their corresponding circuits, involvement of cortical brain structures is presumed in FOG because of frequent manifestation of freezing in situations with emotional or cognitive context.…”

Section: Discussionmentioning

confidence: 60%

“…Although the methods for group comparison of VBM data are highly sophisticated, they are prone to bias from various optional user settings, leading potentially to inconsistencies 4 . Several previous studies investigated the brain alterations associated with FOG in patients with PD using VBM, but they yielded variable outcomes [5][6][7][8][9][10][11] . Because of these differences, potentially related to VBM methodology, it may be worth exploring cortical atrophy with a different method.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Freezing of gait is associated with cortical thinning in mesial frontal cortex

Vaštík¹,

Hok²,

Valošek³

et al. 2017

BIOMED PAP

View full text Add to dashboard Cite

Aims.The relationship between freezing of gait (FOG) and regional brain atrophy has been intensively investigated, but it is still not clearly understood. The study objective was to test whether grey matter (GM) atrophy contributes to FOG in Parkinson´s disease (PD) using a surface-based algorithm. Methods. We investigated 21 patients with PD, 11 with FOG and 10 without FOG. Both groups were assessed using a FOG questionnaire and Hoehn and Yahr staging. High resolution T1-weighted brain images were acquired for each subject using a 1.5T MRI scanner. A surface-based method implemented in FreeSurfer was used to quantify the GM atrophy. A vertex-wise and region of interest (ROI) comparison of spatially normalized subject data using a general linear model and the Wilcoxon rank sum test were to assess significant group differences. Results. Higher global levels of cortical atrophy were detected in freezers, although this was not statistically significant. The vertex-wise analysis revealed significant local reduction in grey matter thickness in the left supplementary motor area, m iddle/anterior cingulate cortex, temporal pole and right frontal operculum in freezers at P<0.001, uncorrected. The ROI analysis of average thickness confirmed the regional atrophy in bilateral anterior and posterior cingulate cortices. No significant relative regional cortical atrophy was observed in non-freezers. Conclusion. FOG was associated with regional cortical atrophy, especially in mesial frontal and cingulate cortices. Our findings provide additional evidence that the development of FOG in patients with PD is associated with local structural cortical changes.

show abstract

Section: Discussionmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Freezing of gait is associated with cortical thinning in mesial frontal cortex

Vaštík¹,

Hok²,

Valošek³

et al. 2017

BIOMED PAP

View full text Add to dashboard Cite

show abstract

“…For example, loss of integrity of the bilateral pedunculopontine tracts, the corpus callosum, the corticospinal tract, the cingulum, and the superior longitudinal fasciculus is related to freezing of gait (Canu et al, 2015). Significant loss of integrity in the bilateral superior longitudinal fasciculus, the bilateral anterior corona radiata, and the left genu of the corpus callosum may account for postural instability in patients with PD (Gu et al, 2014).…”

Section: Aging Of White Matter In Neurodegenerative Diseasesmentioning

confidence: 99%

Aging of cerebral white matter

Liu

Yang

Xia

et al. 2017

Ageing Research Reviews

207

141

View full text Add to dashboard Cite

White matter (WM) occupies a large volume of the human cerebrum and is mainly composed of myelinated axons and myelin-producing glial cells. The myelinated axons within WM are the structural foundation for efficient neurotransmission between cortical and subcortical areas. Similar to neuron-enriched gray matter areas, WM undergoes a series of changes during the process of aging. WM malfunction can induce serious neurobehavioral and cognitive impairments. Thus, age-related changes in WM may contribute to the functional decline observed in the elderly. In addition, aged WM becomes more susceptible to neurological disorders, such as stroke, traumatic brain injury (TBI), and neurodegeneration. In this review, we summarize the structural and functional alterations of WM in natural aging and speculate on the underlying mechanisms. We also discuss how age-related WM changes influence the progression of various brain disorders, including ischemic and hemorrhagic stroke, TBI, Alzheimer’s disease, and Parkinson’s disease. Although the physiology of WM is still poorly understood relative to gray matter, WM is a rational therapeutic target for a number of neurological and psychiatric conditions.

show abstract

“…For instance, Lenka et al 59 and Canu et al, 60 evaluating fMRI resting-state activity, provided completely different patterns of functional changes. The former described a reduced connectivity between parietal and somatosensory cortex, whereas the latter 60 a more consistent decrease of functional connectivity between the SMC and SMA. fNIRS, performed using different walking tasks, highlights the role of the PFC either during postural control of PD patients or during the emergency of FOG symptoms.…”

Section: What Fnirs Teaches Us About Gait Control In Neurological Patmentioning

confidence: 99%

Near-Infrared Spectroscopy in Gait Disorders: Is It Time to Begin?

Gramigna

Pellegrino

Cerasa

et al. 2017

Neurorehabil Neural Repair

View full text Add to dashboard Cite

Walking is a complex motor behavior with a special relevance in clinical neurology. Many neurological diseases, such as Parkinson's disease and stroke, are characterized by gait disorders whose neurofunctional correlates are poorly investigated. Indeed, the analysis of real walking with the standard neuroimaging techniques poses strong challenges, and only a few studies on motor imagery or walking observation have been performed so far. Functional near-infrared spectroscopy (fNIRS) is becoming an important research tool to assess functional activity in neurological populations or for special tasks, such as walking, because it allows investigating brain hemodynamic activity in an ecological setting, without strong immobility constraints. A systematic review following PRISMA guidelines was conducted on the fNIRS-based examination of gait disorders. Twelve of the initial yield of 489 articles have been included in this review. The lesson learnt from these studies suggest that oxy-hemoglobin levels within the prefrontal and premotor cortices are more sensitive to compensation strategies reflecting postural control and restoration of gait disorders. Although this field of study is in its relative infancy, the evidence provided encourages the translation of fNIRS in clinical practice, as it offers a unique opportunity to explore in depth the activity of the cortical motor system during real walking in neurological patients. We also discuss to what extent fNIRS may be applied for assessing the effectiveness of rehabilitation programs.

show abstract

Brain structural and functional connectivity in Parkinson's disease with freezing of gait

Abstract: This study suggests that FoG in PD can be the result of a poor structural and functional integration between motor and extramotor (cognitive) neural systems.

Cited by 147 publications

References 69 publications

Freezing of gait is associated with cortical thinning in mesial frontal cortex

Freezing of gait is associated with cortical thinning in mesial frontal cortex

Aging of cerebral white matter

Near-Infrared Spectroscopy in Gait Disorders: Is It Time to Begin?

Contact Info

Product

Resources

About