Brain signal intensity changes as biomarkers in amyotrophic lateral sclerosis

Vázquez-Costa, J.F.; Mazón, Miguel; Polo, J. Carreres; Hervás, David; Pérez‐Tur, Jordi; Martí‐Bonmatí, Luis; Sevilla, Teresa

doi:10.1111/ane.12863

Cited by 29 publications

(33 citation statements)

References 38 publications

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“…In contrast, healthy controls showed no sex‐specific differences in FLAIR alterations, as reported by Gawne‐Cain et al Sex‐specific differences in FLAIR lesions were reported for MS patients despite balanced age and disease duration . In ALS research, effects of sex on FLAIR hyperintensity were not detected or not analyzed . Sex‐specific differences may be due to outliers with low TLN in the small sample size of female ALS patients ( n = 8).…”

Section: Discussionmentioning

confidence: 68%

“…Consistent with this finding, we detected distinct effects of age on TLN and TLV. LST revealed FLAIR hyperintensity in both ALS patients and healthy controls, as reported in other studies . FLAIR lesions were observed to be dependent on sex and more frequent in male ALS patients than in female ALS patients as well as male healthy controls.…”

Section: Discussionmentioning

confidence: 76%

“…LST revealed FLAIR hyperintensity in both ALS patients and healthy controls, as reported in other studies. 8,13,14,23 FLAIR lesions were observed to be dependent on sex and more frequent in male ALS patients than in female ALS patients as well as male healthy controls. In contrast, healthy controls showed no sex-specific differences in FLAIR alterations, as reported by Gawne-Cain et al 7 Sexspecific differences in FLAIR lesions were reported for MS patients despite balanced age and disease duration.…”

Section: Discussionmentioning

confidence: 93%

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Value of fluid‐attenuated inversion recovery MRI data analyzed by the lesion segmentation toolbox in amyotrophic lateral sclerosis

Wirth

Johannesen

Khomenko

et al. 2018

Magnetic Resonance Imaging

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Background MRI fluid‐attenuated inversion recovery (FLAIR) studies reported hyperintensity in the corticospinal tract and corpus callosum of patients with amyotrophic lateral sclerosis (ALS). Purpose To evaluate the lesion segmentation toolbox (LST) for the objective quantification of FLAIR lesions in ALS patients. Study Type Retrospective. Population Twenty‐eight ALS patients (eight females, mean age: 50 range: 24–73, mean ALSFRS‐R sum score: 36) were compared with 31 age‐matched healthy controls (12 females, mean age: 45, range: 25–67). ALS patients were treated with riluzole and additional G‐CSF (granulocyte‐colony stimulating factor) on a named patient basis. Field Strength/Sequence 1.5 T, FLAIR, T1‐weighted MRI. Assessment The lesion prediction algorithm (LPA) of the LST enabled the extraction of individual binary lesion maps, total lesion volume (TLV), and number (TLN). Location and overlap of FLAIR lesions across patients were investigated by registration to FLAIR average space and an atlas. ALS‐specific functional rating scale revised (ALSFRS‐R), disease progression, and survival since diagnosis served as clinical correlates. Statistical Tests Univariate analysis of variance (ANOVA), repeated‐measures ANOVA, t‐test, Bravais‐Pearson correlation, Chi‐square test of independence, Kaplan–Meier analysis, Cox‐regression analysis. Results Both ALS patients and healthy controls exhibited FLAIR alterations. TLN significantly depended on age (F(1,54) = 24.659, P < 0.001) and sex (F(1,54) = 5.720, P = 0.020). ALS patients showed higher TLN than healthy controls depending on sex (F(1, 54) = 5.076, P = 0.028). FLAIR lesions were small and most pronounced in male ALS patients. FLAIR alterations were predominantly detected in the superior and posterior corona radiata, anterior capsula interna, and posterior thalamic radiation. Patients with pyramidal tract (PT) lesions exhibited significantly inferior survival than patients without PT lesions (P = 0.013). Covariate age exhibited strong prognostic value for survival (P = 0.015). Data Conclusion LST enables the objective quantification of FLAIR alterations and is a potential prognostic biomarker for ALS. Level of Evidence: 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;50:552–559.

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 93%

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Value of fluid‐attenuated inversion recovery MRI data analyzed by the lesion segmentation toolbox in amyotrophic lateral sclerosis

Wirth

Johannesen

Khomenko

et al. 2018

Magnetic Resonance Imaging

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“…Fasciculations were most common in cervical‐innervated muscles, regardless of the region of ALS onset. Direct correlations were noted between the fasciculations and decline in body mass index, loss of sonographically measured muscle thickness, and UMN impairment, as defined by the Upper Motor Neuron Score . An inverse correlation was noted with function, as measured by the ALS Functional Rating Scale Score—Revised (ALSFRS‐R).…”

Section: Muscle Ultrasound In Alsmentioning

confidence: 92%

Ultrasound in the Diagnosis and Monitoring of Amyotrophic Lateral Sclerosis: A Review

Hobson‐Webb

Simmons

2019

Muscle and Nerve

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Neuromuscular ultrasound is complementary to electrodiagnostic (EDx) testing and is useful in enhancing the diagnosis of mononeuropathies, peripheral nerve trauma, and demyelinating polyneuropathies. There is increasing interest in using ultrasound both to aid in the diagnosis of amyotrophic lateral sclerosis (ALS) and to monitor its progression. In this article we review the relevant literature on ultrasound in ALS. Ultrasound is more sensitive than EDx in identifying fasciculations in patients with ALS. It can detect decreased muscle thickness, increased muscle echointensity and echovariance, and reduced peripheral nerve size in these patients. Ultrasound is also a helpful tool in assessment of diaphragm function. Although additional studies are required to define the exact role of ultrasound in the evaluation and monitoring of ALS, it can improve the diagnostic yield in patients when ALS is suspected, but insufficiently supported, by clinical and EDx examinations. Muscle Nerve 60: 114–123, 2019

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“…Age, gender, date of onset of motor symptoms, region of onset (bulbar and spinal), disability (ALSFRS-R) and the degree of UMN impairment (UMN score) 25 were recorded for all MND patients.…”

Section: Clinical Examinationmentioning

confidence: 99%

The width of the third ventricle associates with cognition and behaviour in motor neuron disease

et al. 2018

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Brain signal intensity changes as biomarkers in amyotrophic lateral sclerosis

Cited by 29 publications

References 38 publications

Value of fluid‐attenuated inversion recovery MRI data analyzed by the lesion segmentation toolbox in amyotrophic lateral sclerosis

Value of fluid‐attenuated inversion recovery MRI data analyzed by the lesion segmentation toolbox in amyotrophic lateral sclerosis

Ultrasound in the Diagnosis and Monitoring of Amyotrophic Lateral Sclerosis: A Review

The width of the third ventricle associates with cognition and behaviour in motor neuron disease

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