Brain resting state functional magnetic resonance imaging in patients with takotsubo cardiomyopathy an inseparable pair of brain and heart

Sabisz, Agnieszka; Treder, N.; Fijałkowska, Marta; Siemiński, Mariusz; Fijałkowska, Jadwiga; Naumczyk, Patrycja; Nowak, Radosław; Jaguszewski, Miłosz; Cwalina, Natalia; Gruchała, Marcin; Szurowska, Edyta; Fijałkowski, Marcin

doi:10.1016/j.ijcard.2016.09.067

Cited by 12 publications

(25 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As summarized by Beissner and colleagues 7 , the brain regions involved in the control of vegetative functions also play a crucial role in executive and salience processing, and are to a certain extent part of the default-mode network. Interestingly, in this context, a currently published rsfMRI study showed increased connectivity of areas in the precuneus and decreased connectivity in the ventromedial prefrontal cortex of TTS patients compared to healthy controls, indicating an increased involvement of the default mode network in TTS 4 . Given that the TTS patients of that study reported enhanced anxiety levels and often experienced negative affects, Sabiz and colleagues suggested that this increased focus on internal and self-regulation processes might reflect an inefficient emotion regulation mechanism in the patients 4 .…”

Section: Discussionmentioning

confidence: 87%

“…This raises the question whether brain alterations involved in the pathophysiology of TTS are only present during the acute phase, or perhaps pre- or post-existent. In this context, literature suggests that a history of neurological and psychiatric disorders might induce functional and structural changes within the brain leading to sympathetic hyperactivation, excessive catecholamine release and subsequently TTS 3, 4, 16 . Therefore, pre-existing alterations of the respective brain areas might serve as a potential risk factor for TTS.…”

Section: Discussionmentioning

confidence: 99%

“…Given that external stressors are a unique feature that provoke a TTS event, it is conceivable that TTS is triggered by neuronal alterations in the limbic system, presuming an emotional hypersensitivity or disturbed emotional processing in these patients. In fact, first studies provide insights into neuronal alterations in brain regions constituting the limbic and the central autonomic nervous system 3, 4 . Research in the field of neuroimaging and TTS is rather sparse and limited to studies applying hypotheses-driven mass-univariate statistics 3, 4 .…”

Section: Introductionmentioning

confidence: 99%

“…In fact, first studies provide insights into neuronal alterations in brain regions constituting the limbic and the central autonomic nervous system 3, 4 . Research in the field of neuroimaging and TTS is rather sparse and limited to studies applying hypotheses-driven mass-univariate statistics 3, 4 . However, with this statistical approach it is not possible to draw conclusions about whether patients with TTS show homogeneous neural alterations, i.e.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Takotsubo Syndrome – Predictable from brain imaging data

Klein

Hiestand

Ghadri

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Takotsubo syndrome (TTS) is characterized by acute left ventricular dysfunction, with a hospital-mortality rate similar to acute coronary syndrome (ACS). However, the aetiology of TTS is still unknown. In the present study, a multivariate pattern analysis using machine learning with multimodal magnetic resonance imaging (MRI) data of the human brain of TTS patients and age- and gender-matched healthy control subjects was performed. We found consistent structural and functional alterations in TTS patients compared to the control group. In particular, anatomical and neurophysiological measures from brain regions constituting the emotional-autonomic control system contributed to a prediction accuracy of more than 82%. Thus, our findings demonstrate homogeneous neuronal alterations in TTS patients and substantiate the importance of the concept of a brain-heart interaction in TTS.

show abstract

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Takotsubo Syndrome – Predictable from brain imaging data

Klein

Hiestand

Ghadri

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Furthermore, an rs-fMRI study on default mode network found increase in the precuneus and decrease in the ventromedial prefrontal cortex connectivity in non-acute phase TTS patients compared to healthy controls [9]. Another group applied whole-brain and subnetwork analyses for parasympathetic network, sympathetic network and default mode network in 15 non-acute phase TTS patients and found significant connectivity decrease in all networks, but in particular, in brain regions associated with autonomic functions and regulation of limbic system (i.e.…”

Section: Introductionmentioning

confidence: 97%

Functional neuroimaging in the acute phase of Takotsubo syndrome: volumetric and functional changes of the right insular cortex

et al. 2020

View full text Add to dashboard Cite

Background A brain-heart interaction has been proposed in Takotsubo syndrome (TTS). Structural changes in the limbic system and hypoconnectivity between certain brain areas in the chronic phase of the disease have been reported, but little is known concerning functional neuroimaging in the acute phase. We hypothesized anatomical and functional changes in the central nervous system and investigated whole-brain volumetric and functional connectivity alterations in the acute phase TTS patients compared to controls. Methods Anatomical and resting-state functional magnetic resonance imaging were performed in postmenopausal females: thirteen in the acute TTS phase and thirteen healthy controls without evidence of coronary artery disease. Voxel-based morphometry and graph theoretical analysis were applied to identify anatomical and functional differences between patients and controls. Results Significantly lower gray matter volumes were found in TTS patients in the right middle frontal gyrus (p = 0.004) and right subcallosal cortex (p = 0.009) compared to healthy controls. When lower threshold was applied, volumetric changes were noted in the right insular cortex (p = 0.0113), the right paracingulate cortex (p = 0.012), left amygdala (p = 0.018), left central opercular cortex (p = 0.017), right (p = 0.013) and left thalamus (p = 0.017), and left cerebral cortex (p = 0.017). Graph analysis revealed significantly (p < 0.01) lower functional connectivity in TTS patients compared to healthy controls, particularly in the connections originating from the right insular cortex, temporal lobes, and precuneus. Conclusion In the acute phase of TTS volumetric changes in frontal regions and the central autonomic network (i.e. insula, anterior cingulate cortex, and amygdala) were noted. In particular, the right insula, associated with sympathetic autonomic tone, had both volumetric and functional changes.

show abstract

The role of central autonomic nervous system dysfunction in Takotsubo syndrome: a systematic review

et al. 2022

View full text Add to dashboard Cite

Introduction Takotsubo syndrome (TTS), also known as stress cardiomyopathy or “broken heart” syndrome, is a mysterious condition that often mimics an acute myocardial infarction. Both are characterized by left ventricular systolic dysfunction. However, this dysfunction is reversible in the majority of TTS patients. Purpose Recent studies surprisingly demonstrated that TTS, initially perceived as a benign condition, has a long-term prognosis akin to myocardial infarction. Therefore, the health consequences and societal impact of TTS are not trivial. The pathophysiological mechanisms of TTS are not yet completely understood. In the last decade, attention has been increasingly focused on the putative role of the central nervous system in the pathogenesis of TTS. Conclusion In this review, we aim to summarize the state of the art in the field of the brain–heart axis, regional structural and functional brain abnormalities, and connectivity aberrancies in TTS.

show abstract

Brain resting state functional magnetic resonance imaging in patients with takotsubo cardiomyopathy an inseparable pair of brain and heart

Cited by 12 publications

References 35 publications

Takotsubo Syndrome – Predictable from brain imaging data

Takotsubo Syndrome – Predictable from brain imaging data

Functional neuroimaging in the acute phase of Takotsubo syndrome: volumetric and functional changes of the right insular cortex

The role of central autonomic nervous system dysfunction in Takotsubo syndrome: a systematic review

Contact Info

Product

Resources

About