Brain response to calorie restriction

Fusco, Salvatore; Pani, Giovambattista

doi:10.1007/s00018-012-1223-y

Cited by 57 publications

(42 citation statements)

References 167 publications

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“…Administration of RAs induces many of the beneficial effects observed after DR. DR is able to ameliorate age-related insulin resistance and degenerative brain diseases, and similar results have been described after treatment with RAs343536. Both DR and administration of RAs are able to protect from ischemic stroke in the brain373839. Signaling pathways activated by the interaction between RAs and nuclear receptors have also been considered to have tumor-, and immune suppressive effects, just as DR93340.…”

Section: Discussionmentioning

confidence: 61%

A signature of renal stress resistance induced by short-term dietary restriction, fasting, and protein restriction

Jongbloed

Saat

Verweij

et al. 2017

Sci Rep

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During kidney transplantation, ischemia-reperfusion injury (IRI) induces oxidative stress. Short-term preoperative 30% dietary restriction (DR) and 3-day fasting protect against renal IRI. We investigated the contribution of macronutrients to this protection on both phenotypical and transcriptional levels. Male C57BL/6 mice were fed control food ad libitum, underwent two weeks of 30%DR, 3-day fasting, or received a protein-, carbohydrate- or fat-free diet for various periods of time. After completion of each diet, renal gene expression was investigated using microarrays. After induction of renal IRI by clamping the renal pedicles, animals were monitored seven days postoperatively for signs of IRI. In addition to 3-day fasting and two weeks 30%DR, three days of a protein-free diet protected against renal IRI as well, whereas the other diets did not. Gene expression patterns significantly overlapped between all diets except the fat-free diet. Detailed meta-analysis showed involvement of nuclear receptor signaling via transcription factors, including FOXO3, HNF4A and HMGA1. In conclusion, three days of a protein-free diet is sufficient to induce protection against renal IRI similar to 3-day fasting and two weeks of 30%DR. The elucidated network of common protective pathways and transcription factors further improves our mechanistic insight into the increased stress resistance induced by short-term DR.

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Section: Discussionmentioning

confidence: 61%

A signature of renal stress resistance induced by short-term dietary restriction, fasting, and protein restriction

Jongbloed

Saat

Verweij

et al. 2017

Sci Rep

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“…Finally, there is CR, a dietary practice known to reduce the progression of many age-related diseases. Interestingly, this particular dietary strategy, which the KD was originally designed to mimic, has been an intense focus for researchers interested in the mechanisms underlying aging/longevity, neurological diseases, and a host of other conditions (58)(59)(60).…”

Section: Variations On the Kdmentioning

confidence: 99%

Ketogenic diets, mitochondria, and neurological diseases

Gano

Patel

Rho

2014

Journal of Lipid Research

213

193

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“…Animal studies have shown that daily CR, intermittent fasting (IF), and alternate day fasting (ADF) not only modify the nutrient sensing pathways in the brain (Figure 2) but also increase synaptic plasticity, neurogenesis and neuroprotection (Fusco and Pani, 2013). CR and IF delay features of aging both on the microscopic and global levels (Pani, 2015).…”

Section: Unraveling the Relationships Among Calorie Restriction Lmentioning

confidence: 99%

Nutritional strategies to optimise cognitive function in the aging brain

Wahl

Cogger

Solon-Biet

et al. 2016

Ageing Research Reviews

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Old age is the greatest risk factor for most neurodegenerative diseases. During recent decades there have been major advances in understanding the biology of aging, and the development of nutritional interventions that delay aging including calorie restriction (CR) and intermittent fasting (IF), and chemicals that influence pathways linking nutrition and aging processes. CR influences brain aging in many animal models and recent findings suggest that dietary interventions can influence brain health and dementia in older humans. The role of individual macronutrients in brain aging also has been studied, with conflicting results about the effects of dietary protein and carbohydrates. A new approach known as the Geometric Framework (GF) has been used to unravel the complex interactions between macronutrients (protein, fat, and carbohydrate) and total energy on outcomes such as aging. These studies have shown that low-protein, high-carbohydrate (LPHC) diets are optimal for lifespan in ad libitum fed animals, while total calories have minimal effect once macronutrients are taken into account. One of the primary purposes of this review is to explore the notion that macronutrients may have a more translational potential than CR and IF in humans, and therefore there is a pressing need to use GF to study the impact of diet on brain aging. Furthermore, given the growing recognition of the role of aging biology in dementia, such studies might provide a new approach for dietary interventions for optimizing brain health and preventing dementia in older people.

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Brain response to calorie restriction

Cited by 57 publications

References 167 publications

A signature of renal stress resistance induced by short-term dietary restriction, fasting, and protein restriction

A signature of renal stress resistance induced by short-term dietary restriction, fasting, and protein restriction

Ketogenic diets, mitochondria, and neurological diseases

Nutritional strategies to optimise cognitive function in the aging brain

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