Brain perfusion imaging: How does it work and what should I use?

McGehee, Blake E.; Pollock, Jeffrey M.; Maldjian, Joseph A.

doi:10.1002/jmri.23645

Cited by 48 publications

(38 citation statements)

References 78 publications

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“…[189][190][191][192] Perfusion studies using either arterial spin labeling (ASL) 193 or dynamic susceptibility contrast-enhanced perfusionweighted imaging (DSC PWI) 194 have demonstrated reduced CBF in moderate to severe TBI and in chronic mTBI patients. Furthermore, experimental animal models in moderate to severe TBI have demonstrated a decrease in venous blood oxygenation that accompanies the decrease in arterial blood supply, 195 which is suggestive of brain tissue at risk for hypoxia.…”

Section: Perfusion Imagingmentioning

confidence: 99%

“…ASL can quantify absolute CBF, 192,206,207 and a few studies reported perfusion deficits in chronic TBI patients using ASL. Most recently, the MR perfusion study community unanimously recommended the use of pseudocontinuous ASL (pCASL) with 3D gradient and spin echo (GRASE) as the readout for absolute CBF quantification.…”

Section: Perfusion Imagingmentioning

confidence: 99%

“…DSC-PWI offers higher resolution and better SNR ratio. 192 DSC-PWI, however, only offers relative rather than absolute quantification of CBF because of the lack of a reliable arterial input function (AIF). 192 All these results suggest that, instead of just CBF, CMRO 2 might be more important to serve as the treatment target.…”

Section: Perfusion Imagingmentioning

confidence: 99%

“…192 DSC-PWI, however, only offers relative rather than absolute quantification of CBF because of the lack of a reliable arterial input function (AIF). 192 All these results suggest that, instead of just CBF, CMRO 2 might be more important to serve as the treatment target. In terms of improving either CBF or brain tissue oxygenation, the final goal is to keep the brain tissue at a reasonable CMRO 2 level to maintain homeostasis.…”

Section: Perfusion Imagingmentioning

confidence: 99%

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Evaluating the Role of Reduced Oxygen Saturation and Vascular Damage in Traumatic Brain Injury Using Magnetic Resonance Perfusion-Weighted Imaging and Susceptibility-Weighted Imaging and Mapping

Kou

Haacke³

2015

Topics in Magnetic Resonance Imaging

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The cerebral vasculature, along with neurons and axons, is vulnerable to biomechanical insult during traumatic brain injury (TBI). Trauma-induced vascular injury is still an underinvestigated area in TBI research. Cerebral blood flow and metabolism could be important future treatment targets in neural critical care. Magnetic resonance imaging offers a number of key methods to probe vascular injury and its relationship with traumatic hemorrhage, perfusion deficits, venous blood oxygen saturation changes, and resultant tissue damage. They make it possible to image the hemodynamics of the brain, monitor regional damage, and potentially show changes induced in the brain's function not only acutely but also longitudinally following treatment. These methods have recently been used to show that even mild TBI (mTBI) subjects can have vascular abnormalities, and thus they provide a major step forward in better diagnosing mTBI patients.

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Section: Perfusion Imagingmentioning

confidence: 99%

Section: Perfusion Imagingmentioning

confidence: 99%

Section: Perfusion Imagingmentioning

confidence: 99%

Section: Perfusion Imagingmentioning

confidence: 99%

See 2 more Smart Citations

Evaluating the Role of Reduced Oxygen Saturation and Vascular Damage in Traumatic Brain Injury Using Magnetic Resonance Perfusion-Weighted Imaging and Susceptibility-Weighted Imaging and Mapping

Kou

Haacke³

2015

Topics in Magnetic Resonance Imaging

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“…Quantitative data processing includes data cleaning (removal of individual images with noise spikes or severe motion artifact), realignment (separately for label and control images), spatial smoothing, and calculation of mean cerebral blood flow (CBF) maps; our methods and experience with this technique has been well documented (Deibler, et al, 2008a,Deibler, et al, 2008b,Deibler, et al, 2008c,Johnston, et al, 2013,Maldjian, et al, 2009,Maldjian, et al, 2008,McGehee, et al, 2012,Pollock, et al, 2008a,Pollock, et al, 2008b,Pollock, et al, 2009a,Pollock, et al, 2009b,Pollock, et al, 2008c,Pollock, et al, 2011,Pollock, et al, 2009c,Tan, et al, 2009,Watts, et al, 2013). The CBF maps were normalized to MNI space by coregistering to the T1 structural data using SPM8, and then combining this transformation matrix with the parameters computed in the VBM8 normalization procedure, allowing derivation of the gray matter cerebral blood flow (GMCBF) measure analyzed.…”

Section: Methodsmentioning

confidence: 99%

Heritability and genetic association analysis of neuroimaging measures in the Diabetes Heart Study

Raffield

Cox

Hugenschmidt

et al. 2015

Neurobiology of Aging

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Patients with type 2 diabetes are at increased risk of age-related cognitive decline and dementia. Neuroimaging measures such as white matter lesion volume, brain volume, and fractional anisotropy may reflect the pathogenesis of these cognitive declines, and genetic factors may contribute to variability in these measures. This study examined multiple neuroimaging measures in 465 participants from 238 families with extensive genotype data in the type 2 diabetes enriched Diabetes Heart Study-Mind cohort. Heritability of these phenotypes and their association with candidate single nucleotide polymorphisms (SNPs) and SNP data from genome-and exome-wide arrays was explored. All neuroimaging measures analysed were significantly heritable (ĥ2 =0.55–0.99 in unadjusted models). Seventeen candidate SNPs (from 16 genes/regions) associated with neuroimaging phenotypes in prior studies showed no significant evidence of association. A missense variant (rs150706952, A432V) in PLEKHG4B from the exome-wide array was significantly associated with white matter mean diffusivity (p=3.66×10−7) and gray matter mean diffusivity (p=2.14×10−7). This analysis suggests genetic factors contribute to variation in neuroimaging measures in a population enriched for metabolic disease and other associated comorbidities.

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Functional MRI technologies in the study of medication treatment effect on Alzheimer's disease

et al. 2018

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Alzheimer's disease (AD) is the most common cause of late-life dementia. Characterized by progressive neurodegeneration, the disease is expressed as gradual memory loss together with decline in cognitive abilities and other brain functions. Despite extensive research over the past decade, the cause and cure of AD both remain largely unknown. Several AD-associated deficits have been targeted for interventions, including those based on amyloid-beta, tau, and inflammation hypotheses. Only 2 types of medications-cholinesterase inhibitors and memantine-have been approved, to control the cognitive symptoms of AD such as the loss of memory, language, and executive function. Noninvasive in vivo functional magnetic resonance imaging (MRI) technologies, including the blood oxygen level-dependent functional MRI, arterial spin labeling-based perfusion MRI, and the proton magnetic resonance spectroscopy have been used to study the effect of ChEIs and memantine in the brain. Most of these studies have demonstrated increased functional activation and connectivity, increased regional brain blood flow and volume post-treatment, and positive responses of critical brain metabolites reflecting neuronal status and functionality in patients with AD and mild cognitive impairment. The findings have contributed to the understanding of the mechanisms underlying the medication treatments and support the crucial role of functional MRI technologies in the development and refinement of AD medication therapies.

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Brain perfusion imaging: How does it work and what should I use?

Cited by 48 publications

References 78 publications

Evaluating the Role of Reduced Oxygen Saturation and Vascular Damage in Traumatic Brain Injury Using Magnetic Resonance Perfusion-Weighted Imaging and Susceptibility-Weighted Imaging and Mapping

Evaluating the Role of Reduced Oxygen Saturation and Vascular Damage in Traumatic Brain Injury Using Magnetic Resonance Perfusion-Weighted Imaging and Susceptibility-Weighted Imaging and Mapping

Heritability and genetic association analysis of neuroimaging measures in the Diabetes Heart Study

Functional MRI technologies in the study of medication treatment effect on Alzheimer's disease

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