Brain Morphometry, T2-Weighted Hyperintensities, and IQ in Children With Neurofibromatosis Type 1

Alterations in Brain Morphology by MRI in Adults with Neurofibromatosis 1

“…Our ndings are consistent with those of previous studies in children and smaller groups of adults with NF1 (23,25). Also, previous brain MRI studies in people with NF1 have found evidence of increased total white matter volume, increased brain volume, and megalencephaly (6,7,9,10,(19)(20)(21)(22). Similarly, we found strong correlation between 2D CC size and total and CC white matter volume.…”

Alterations in Brain Morphology by MRI in Adults with Neurofibromatosis 1

“…Our ndings are consistent with those of previous studies in children and smaller groups of adults with NF1 (23,25). Also, previous brain MRI studies in people with NF1 have found evidence of increased total white matter volume, increased brain volume, and megalencephaly (6,7,9,10,(19)(20)(21)(22). Similarly, we found strong correlation between 2D CC size and total and CC white matter volume.…”

Gyrification, cortical and subcortical morphometry in neurofibromatosis type 1: an uneven profile of developmental abnormalities

“…We confirmed that children with NF1 have larger intracranial volumes than typically developing children (approximately 10%) and our findings indicate that this enlargement is mainly a result of increased WM volume. At the lobar level, our results indicate that patients with NF1 have larger WM volumes in the frontal lobe (consistent with prior studies [15,16,22]), temporal lobe (in agreement with voxel-based morphometry findings in a partly overlapping cohort [22]), and left parietal lobe. We did not find alterations in the occipital lobe.…”

Alterations in White Matter Microstructure in Neurofibromatosis-1

“…First, our data replicate and support previous sMRI findings indicating white matter volumetric enlargement in NF1 patients [12], [13], [14]. However, our study sheds new light on the widespread nature of white matter microstructural alterations in NF1, a pattern that has not been observed in previous studies that focused on a limited selection of white matter tracts.…”

Alterations in Brain Morphology by MRI in Adults with Neurofibromatosis 1

“…Our ndings are consistent with those of previous studies in children and smaller groups of adults with NF1 (23,25). Also, previous brain MRI studies in people with NF1 have found evidence of increased total white matter volume, increased brain volume, and megalencephaly (6,7,9,10,(19)(20)(21)(22). Similarly, we found strong correlation between 2D CC size and total and CC white matter volume.…”

Gyrification, cortical and subcortical morphometry in neurofibromatosis type 1: an uneven profile of developmental abnormalities

“…We confirmed that children with NF1 have larger intracranial volumes than typically developing children (approximately 10%) and our findings indicate that this enlargement is mainly a result of increased WM volume. At the lobar level, our results indicate that patients with NF1 have larger WM volumes in the frontal lobe (consistent with prior studies [15,16,22]), temporal lobe (in agreement with voxel-based morphometry findings in a partly overlapping cohort [22]), and left parietal lobe. We did not find alterations in the occipital lobe.…”

Alterations in White Matter Microstructure in Neurofibromatosis-1

“…First, our data replicate and support previous sMRI findings indicating white matter volumetric enlargement in NF1 patients [12], [13], [14]. However, our study sheds new light on the widespread nature of white matter microstructural alterations in NF1, a pattern that has not been observed in previous studies that focused on a limited selection of white matter tracts.…”

Alterations in Brain Morphology by MRI in Adults with Neurofibromatosis 1

“…Our ndings are consistent with those of previous studies in children and smaller groups of adults with NF1 (23,25). Also, previous brain MRI studies in people with NF1 have found evidence of increased total white matter volume, increased brain volume, and megalencephaly (6,7,9,10,(19)(20)(21)(22). Similarly, we found strong correlation between 2D CC size and total and CC white matter volume.…”

Gyrification, cortical and subcortical morphometry in neurofibromatosis type 1: an uneven profile of developmental abnormalities

“…We confirmed that children with NF1 have larger intracranial volumes than typically developing children (approximately 10%) and our findings indicate that this enlargement is mainly a result of increased WM volume. At the lobar level, our results indicate that patients with NF1 have larger WM volumes in the frontal lobe (consistent with prior studies [15,16,22]), temporal lobe (in agreement with voxel-based morphometry findings in a partly overlapping cohort [22]), and left parietal lobe. We did not find alterations in the occipital lobe.…”

Alterations in White Matter Microstructure in Neurofibromatosis-1

“…First, our data replicate and support previous sMRI findings indicating white matter volumetric enlargement in NF1 patients [12], [13], [14]. However, our study sheds new light on the widespread nature of white matter microstructural alterations in NF1, a pattern that has not been observed in previous studies that focused on a limited selection of white matter tracts.…”