Brain morphology in children with 47,<scp>XYY</scp> syndrome: a voxel‐ and surface‐based morphometric study

Lepage, Jean‐François; Hong, David S.; Raman, Mira; Marzelli, Matthew; Roeltgen, David P.; Lai, Song; Ross, Judith L.; Reiss, Allan L.

doi:10.1111/gbb.12107

Cited by 19 publications

(10 citation statements)

References 46 publications

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“…Females with TS exhibit weaknesses in face recognition, facial affect discrimination (especially of fear or anger), interpretation of social cues, theory of mind, and problems in social communication. They also may manifest problems in eye tracking and gaze processing, and present with restricted interests or repetitive behaviors [47,107,[110][111][112][113][114][115]. An overlap between the TS behavioral phenotype and 'idiopathic ASD' has been previously suggested [110].…”

Section: Asd In Scasmentioning

confidence: 99%

Sex differences in psychiatric disorders: what we can learn from sex chromosome aneuploidies

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Flash

Reiss

2018

Neuropsychopharmacol

130

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The study of sexual dimorphism in psychiatric and neurodevelopmental disorders is challenging due to the complex interplay of diverse biological, psychological, and social factors. Males are more susceptible to neurodevelopmental disorders including intellectual disability, autism spectrum disorder, and attention-deficit activity disorder. Conversely, after puberty, females are more prone to major depressive disorder and anxiety disorders compared to males. One major biological factor contributing to sex differences is the sex chromosomes. First, the X and Y chromosomes have unique and specific genetic effects as well as downstream gonadal effects. Second, males have one X chromosome and one Y chromosome, while females have two X chromosomes. Thus, sex chromosome constitution also differs between the sexes. Due to this complexity, determining genetic and downstream biological influences on sexual dimorphism in humans is challenging. Sex chromosome aneuploidies, such as Turner syndrome (X0) and Klinefelter syndrome (XXY), are common genetic conditions in humans. The study of individuals with sex chromosome aneuploidies provides a promising framework for studying sexual dimorphism in neurodevelopmental and psychiatric disorders. Here we will review and contrast four syndromes caused by variation in the number of sex chromosomes: Turner syndrome, Klinefelter syndrome, XYY syndrome, and XXX syndrome. Overall we describe an increased rate of attention-deficit hyperactivity disorder and autism spectrum disorder, along with the increased rates of major depressive disorder and anxiety disorders in one or more of these conditions. In addition to contributing unique insights about sexual dimorphism in neuropsychiatric disorders, awareness of the increased risk of neurodevelopmental and psychiatric disorders in sex chromosome aneuploidies can inform appropriate management of these common genetic disorders.

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Section: Asd In Scasmentioning

confidence: 99%

Sex differences in psychiatric disorders: what we can learn from sex chromosome aneuploidies

Green

Flash

Reiss

2018

Neuropsychopharmacol

130

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“…Right hemispheric regional differences have been found in 47,XYY boys (n=10), even when controlling for greater overall volume in this group 14 . The right occipital lobe showed increased gray matter volume, while the insula, inferior frontal gyrus and superior temporal cortex volumes were decreased.…”

mentioning

confidence: 72%

Sex chromosome trisomies are not associated with atypical lateralisation for language

Wilson

Bishop

2018

Preprint

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AimIndividuals with a sex chromosome trisomy (SCT) have disproportionate problems with language compared to nonverbal skills. This may result from disruption to the typical left hemisphere bias for language processing. We tested the hypothesis that SCTs would be associated with reduced left lateralisation for language.MethodIn a cross-sectional design, language laterality was measured during an animation description task using functional transcranial Doppler ultrasonography (fTCD). Data were available for 75 children with an SCT (26 47,XXX girls, 25 47,XXY boys, and 24 47,XYY boys; mean age was 11;4 years, SD = 3;10 years), and 132 comparison children with typical karyotypes (69 boys; mean age was 9;1 years, SD = 1;7 years).ResultsLateralisation for language did not differ between the SCT and comparison groups, either in mean laterality index or relative frequency of each laterality category (left, bilateral and right). There were no differences when splitting the SCT group by trisomy. Handedness also showed no group effects.InterpretationOur data provide no evidence for disrupted lateralisation for language in SCTs. The brain basis of the cognitive phenotype in SCTs is unlikely to be a failure of the left hemisphere to specialise for language, as previously suggested.What this paper addsChildren with a sex chromosome trisomy (SCT) have typically lateralised language.This disconfirms theories linking language problems to hemispheric specialization in SCTs

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“…Although most neuroimaging work has focused on 47,XXY groups, a few studies have considered other SCTs. Right hemispheric regional differences have been found in 47,XYY males ( n =10), even when controlling for greater overall volume in this group . The right occipital lobe showed increased grey matter volume, whereas the insula, inferior frontal gyrus, and superior temporal cortex volumes were decreased.…”

mentioning

confidence: 77%

“…Right hemispheric regional differences have been found in 47,XYY males (n=10), even when controlling for greater overall volume in this group. 14 The right occipital lobe showed increased grey matter volume, whereas the insula, inferior frontal gyrus, and superior temporal cortex volumes were decreased. Note, however, that direct comparisons between the hemispheres were not reported.…”

mentioning

confidence: 94%

Sex chromosome trisomies are not associated with atypical lateralization for language

Wilson

Bishop

2018

Develop Med Child Neuro

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AimTo test the hypothesis that sex chromosome trisomies (SCTs) are associated with reduced left lateralization for language.MethodUsing a cross‐sectional design, language laterality was measured during an animation description task using functional transcranial Doppler ultrasonography. Data were available for 75 children with an SCT (47,XXX females [n=26], 47,XXY males [n=25], 47,XYY males [n=24]; mean age 11y 4mo [SD 3y 10mo]) and 132 comparison children with typical karyotypes (69 males, 63 females; mean age 9y 1mo [SD 1y 7mo]).ResultsLateralization for language did not differ between the SCT and comparison groups, either in mean laterality index or relative frequency of each laterality category. There were no differences when splitting the group with an SCT by trisomy. Handedness showed no group effects.InterpretationOur data provide no evidence for disrupted lateralization for language in SCTs. The brain basis of the cognitive phenotype in SCTs is unlikely to be a failure of the left hemisphere to specialize for language, as previously suggested.What this paper adds Children with a sex chromosome trisomy (SCT) have typically lateralized language.This disproves theories linking language problems to hemispheric specialization in SCTs.

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Brain morphology in children with 47,XYY syndrome: a voxel‐ and surface‐based morphometric study

Cited by 19 publications

References 46 publications

Sex differences in psychiatric disorders: what we can learn from sex chromosome aneuploidies

Sex differences in psychiatric disorders: what we can learn from sex chromosome aneuploidies

Sex chromosome trisomies are not associated with atypical lateralisation for language

Sex chromosome trisomies are not associated with atypical lateralization for language

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