Brain Metastasis In A Case Of Canine Transmissible Venereal Tumor After A Supposed Successful Treatment With Vincristine Sulfate

Pinczowski, Pedro; Marina, Gimeno; Carmen, Aceña; Villegas, Ainara; Alba, de Martino; Lluís, Luján

doi:10.1515/acve-2015-0011

Cited by 4 publications

(8 citation statements)

References 10 publications

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“…The neurological signs continued even after successful treatment with vincristine sulfate. Pinczowski et al reported similar results after vincristine sulfate treatment of a dog that also presented with neurological disturbances [8]. The location of the tumor that affected this dog, however, corresponded to what has been found in other cases; exposure of the area with tumor cells can occur because large numbers of blood vessels are present in this area of the brain [8].…”

Section: Resultssupporting

confidence: 61%

“…Pinczowski et al reported similar results after vincristine sulfate treatment of a dog that also presented with neurological disturbances [8]. The location of the tumor that affected this dog, however, corresponded to what has been found in other cases; exposure of the area with tumor cells can occur because large numbers of blood vessels are present in this area of the brain [8]. Treatment is based on the application of vincristine sulfate to doses of 0.025 mg/kg IV or 0.5-0.7 mg/m 2 at weekly intervals for 4 to 8 applications; use of this protocol generally results in tumor remission [1,3,6,7,13].…”

Section: Resultsmentioning

confidence: 68%

“…Before being adopted the dog was living on the streets and would have been exposed to a high risk of TVT transmission. With respect to the cellular spread of the tumor, there are other reports of TVT cerebral metastasis, but in all of them, the primary neoplasm was located in the genitals [8,9]. Reports of extragenital primary TVT, however, are rare [6,10,11].…”

Section: Resultsmentioning

confidence: 99%

“…Dogs with a suppressed immune system are more likely to have a more severe disease [2,5,6]. Due to the mode of transmission, this neoplasm mainly affects the genitals [5][6][7], although parenchymal organs and even the brain can be affected [8,9]. There are few reports of this neoplasm affecting extragenital locations.…”

Section: Introductionmentioning

confidence: 99%

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Cerebral metastasis of transmissible venereal tumor after effective chemotherapy in a dog

Silva-Hidalgo¹,

Guajardo²,

Dávila-Paredes³

et al. 2020

Turk J Vet Anim Sci

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A male mixed breed street dog (age unknown) presented with an ocular mass and multiple ulcerated subcutaneous nodules on both hind limbs which bled easily when touched. Inspection of the genital organs revealed that no masses were present. The ocular mass and nodules were diagnosed as a transmissible venereal tumor (TVT) by fine-needle aspiration cytology. The total remission of the tumor was achieved after 5 applications of vincristine sulfate. The dog was adopted during the remission period, but 5 months after adoption he developed neurological signs and died. The necropsy revealed a mass located in the trunk of the corpus callosum of the right hemisphere of the brain. The cytological, histological, and PCR findings of the brain mass were consistent with a TVT. These findings highlight the need to consider the aggressive metastatic potential of canine TVT, even after apparently effective chemotherapy.

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Section: Resultssupporting

confidence: 61%

Section: Resultsmentioning

confidence: 68%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cerebral metastasis of transmissible venereal tumor after effective chemotherapy in a dog

Silva-Hidalgo¹,

Guajardo²,

Dávila-Paredes³

et al. 2020

Turk J Vet Anim Sci

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“…No entanto, devido ao possível transplante de células tumorais por lambidas, podem ocorrer disseminações para outras partes do corpo (cavidade oral, nasal, pele) sem considerar a metástase. Os locais onde foram relatadas metástases são: rim, bexiga, baço, fígado, pulmões, olhos, amígdalas, língua, cérebro, hipófise, tecido subcutâneo, osso maxilar, linfonodos mesentéricos, peritônio, músculos, glândula mamária (Calderon et al, 2016;Ganguly et al, 2016;Pinczowski et al, 2015;Strakova & Murchison, 2014 Em muitos casos, pode haver extensão do tumor de localização vaginal primária para o colo uterino e o corpo do útero, bem como TVT nasal para os seios maxilar e faríngeo (Amaral et al, 2007); quando o TVT envolve pode ocorrer metástase vascular no globo ocular. O envolvimento da câmara ocular anterior está associado à disseminação hematogênica e ao envolvimento da íris e do corpo ciliar (Amaral et al, 2012;Rodrigues et al, 2001).…”

Section: Fase De Disseminação Ou Metástase (M)unclassified

Imunologia do tumor venéreo transmissível canino: Revisão

Baldrich-Romero¹,

Quiroz²,

Losada³

et al. 2021

Pubvet

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O tumor venéreo transmissível canino é um dos poucos tipos de tumores contagiosos descritos em mamíferos. É transplantado como um aloenxerto de células viáveis na mucosa e/ou pele, onde desencadeia um processo imunológico que varia de acordo com o estágio de desenvolvimento. O TVT possui 4 fases; a fase de progressão (P) caracterizada pela evasão da barreira da histocompatibilidade e a resposta imune por mecanismos imunossupressores, seguida pela fase de estagnação (E) na qual ocorre um processo de estase entre o tumor e o sistema imunológico que permite a remodelação do tecido danificado, na fase de regressão (R), o evento principal é a reativação da resposta imune mediada pela infiltração de linfócitos T e citocinas pró-inflamatórias como a interleucina IL-6 e interferon gama (IFN-γ) , para a remoção do tumor. A fase de metástase (M), ou disseminação do tumor, se desenvolve em hospedeiros não imunocompetentes. Esta revisão descreve em detalhes os processos imunológicos realizados em cada fase.

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Multiple Metastases of a Transmissible Venereal Tumor in a Dog

Faccini

Legramanti

Castro

et al. 2019

Acta Scientiae. Vet.

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Background: Transmissible venereal tumor (TVT) is a common contagious neoplasm in dogs that spreads through coitus. Extra-genital presentations of this tumor are frequent and usually develop through implantation of neoplastic cells on exposed mucosae. TVT metastasis is rare, and when it happens it's usually affecting regional lymph nodes and adjacent cutaneous tissue. Case: A female mixed breed dog, with estimated age of 7 to 11 months old, was rescued from the streets and taken to a veterinary clinic in the city of Porto Alegre, RS. The animal had multiple nodules on its body, vulva, ocular mucosa, and gingiva, along with signs of malnutrition and apathy. Cytological examination of the nodules and vulva was done and yielded a cytologic picture compatible with TVT. Weakly treatment with 0,3mg/m² vincristine sulphate was used until clinical cure was noted. Approximately two weeks after clinical cure, the dog showed a blue colored eye and was referred for ophthalmological, where it was diagnosed with vision loss due to glaucoma secondary to a neoplasm. The eye was then removed and sent for histopathological evaluation. Histopathology of the eye was compatible with TVT diagnosis. One month after enucleation the animal display dispenia, pain, aggressiveness and epistaxis. The animal was euthanized and submitted for post-mortem evaluation. At necropsy there was a well-defined grayish-white, nodule near the thalamus. Similar nodules were also found on the lung, and anterior chamber of the eye. Histologically, all the nodules were compatible with TVT. Immunohistochemical examination was done, with the neoplastic cells being positive for vimentin and negative for cytokeratin, CD79a, CD3 and CD117. Based on the post-mortem examination and clinical history, diagnosis of TVT was given. Discussion: The clinical manifestation of the tumor in the genitalia presented by the animal is characteristic of TVT, but the extragenital presentation is less common. Although extragenital manifestations are well reported, most are due to auto-implantation (contact with the dog's own genitalia) or hetero-implantation (contact with the genitalia of another dog). Metastases originating from the genitalia are markedly less common (5% of cases), and when they occur, they usually affect regional lymph nodes due to lymphatic communication. However, they can also occur in other organs, such as the liver, kidneys, spleen, tonsils, skin and subcutaneous tissue, bone, CNS, mesentery, and eyes. In this case, it is difficult to determine if the ocular tumor reported was due to metastasis or implantation by direct eye contact with TVT cells, since the animal lived on the street, and it was not possible to establish a more accurate history. The dog in this study was treated with vincristine sulfate; however, the treatment was stopped after one month, when no signs of the tumor were observed. Treatment with vincristine is the method of choice for TVT, since it is highly effective. However, rare cases of recurrence after treatment may occur. In addition, t...

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Brain Metastasis In A Case Of Canine Transmissible Venereal Tumor After A Supposed Successful Treatment With Vincristine Sulfate

Cited by 4 publications

References 10 publications

Cerebral metastasis of transmissible venereal tumor after effective chemotherapy in a dog

Cerebral metastasis of transmissible venereal tumor after effective chemotherapy in a dog

Imunologia do tumor venéreo transmissível canino: Revisão

Multiple Metastases of a Transmissible Venereal Tumor in a Dog

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