2006
DOI: 10.2337/diabetes.55.04.06.db05-1323
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Abstract: The structural correlates of impaired cognition in type 2 diabetes are unclear. The present study compared cognition and brain magnetic resonance imaging (MRI) between type 2 diabetic patients and nondiabetic control subjects and assessed the relationship between cognition and MRI findings and blood pressure and metabolic control. The study included 113 patients and 51 control subjects. Brain MRI scans were rated for white matter lesions (WMLs), cortical and subcortical atrophy, and infarcts. Neuropsychologica… Show more

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Cited by 429 publications
(420 citation statements)
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“…With impairment of vasoregulation, spontaneous variations in systemic pressure during everyday activities may perturb cerebral perfusion pressure. Therefore, older diabetic patients may experience larger fluctuations of perfusion pressure that may have implications for cerebral hypoperfusion and brain atrophy [65,66]. Consistently, we found in this study that cerebral flow velocity in diabetes was more passively dependent on blood pressure, as indicated by reduced phase shifts between oscillations in the two physiological variables during resting conditions.…”
Section: E Impairment Of Autoregulation In Diabetessupporting
confidence: 82%
“…With impairment of vasoregulation, spontaneous variations in systemic pressure during everyday activities may perturb cerebral perfusion pressure. Therefore, older diabetic patients may experience larger fluctuations of perfusion pressure that may have implications for cerebral hypoperfusion and brain atrophy [65,66]. Consistently, we found in this study that cerebral flow velocity in diabetes was more passively dependent on blood pressure, as indicated by reduced phase shifts between oscillations in the two physiological variables during resting conditions.…”
Section: E Impairment Of Autoregulation In Diabetessupporting
confidence: 82%
“…We are not aware of any study that has assessed both cognitive functioning and regional brain volumes in individuals with type 2 diabetes. To relate cognition with general brain MRI abnormalities, investigators recently assessed brain atrophy in type 2 diabetic individuals [4,43]. These studies found attention, executive functions, abstract reasoning and memory impairments to be associated with brain atrophy.…”
Section: Discussionmentioning
confidence: 99%
“…There is accumulating evidence that diabetes, in addition to increasing the risk of cardiovascular disease, stroke and kidney failure, may also adversely affect brain function independently from atherosclerotic disease. To date, numerous studies have demonstrated that type 2 diabetes is associated with cognitive deficits (for example [2][3][4][5]). …”
Section: Introductionmentioning
confidence: 99%
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“…The increased availability of imaging has allowed researchers to study the anatomical basis for loss of cognitive function in T2DM. Most of the literature to date has noted cortical and subcortical atrophy and increased white matter lesions coupled with impaired cognitive performance in T2DM, even after controlling for hypertension [13]. However, these studies have included elderly individuals mostly in poor diabetic control.…”
Section: Type 2 Diabetes and The Brainmentioning
confidence: 99%