1996
DOI: 10.1017/s1092852900000663
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Abstract: Recent brain-imaging studies have examined the neuroanatomy and pathophysiology of obsessive-compulsive disorder (OCD). Researchers have used computed tomography and magnetic resonance imaging to look at brain structure and single-photon emission computed tomography and positron emission tomography scanning to look at brain function in OCD subjects. In this article, we review these studies and discuss their methodology. We then present a theoretical model derived from these studies for how the brain mediates O… Show more

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Cited by 12 publications
(4 citation statements)
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“…Further research is needed to explore the possible causal relationship between organicity and OCD. Although current technology for brain computerized tomography and magnetic resonance imaging indicates with a high degree of accuracy the presence of brain lesions related to OCD (Brody & Saxena, 1996), a detailed, high resolution MRI study in which focal lesions are better documented would be more informative. However, it seems that cerebral structural organicity in OCD may be manifested by a core symptomatology of rigid and concrete thinking, an absence of anxiety or depression, a lack of motivation, and a history of being treatment refractory.…”
Section: Discussionmentioning
confidence: 99%
“…Further research is needed to explore the possible causal relationship between organicity and OCD. Although current technology for brain computerized tomography and magnetic resonance imaging indicates with a high degree of accuracy the presence of brain lesions related to OCD (Brody & Saxena, 1996), a detailed, high resolution MRI study in which focal lesions are better documented would be more informative. However, it seems that cerebral structural organicity in OCD may be manifested by a core symptomatology of rigid and concrete thinking, an absence of anxiety or depression, a lack of motivation, and a history of being treatment refractory.…”
Section: Discussionmentioning
confidence: 99%
“…94 As the cohort undergoes puberty, which is accompanied by cortical maturation 95 and synaptic pruning, 9 0. 99 it is possible that PlJVE will increase risk for disorders that typically have a later onset and in w•hich abnormalities of cortical-basal ganglionic circuits have been implicated, such as mood disorders, 100 obsessivecompulsive disorder, 101 and schizophrenia. 93 • 100 • 102 •!03 Certainly, further longitudinal follow-up of this cohort will be of great interest.…”
Section: Non-us Predictorsmentioning
confidence: 99%
“…Recent brain imaging studies have indicated that orbitofrontal cortex and striatum are involved in neuropathology of obsessive‐compulsive disorder (OCD) (1, 2). However there are some contradictory results of these brain imaging studies.…”
mentioning
confidence: 99%