Brain heterogeneity in 1,792 individuals with schizophrenia: effects of illness stage, sites of origin and pathophysiology
Yuchao Jiang,
Lena Palaniyappan,
Xiao Chang
et al.
Abstract:ImportanceSchizophrenia is characterized with greater variability beyond the mean differences in brain structures. This variability is often assumed to be static, reflecting the presence of heterogeneous subgroups, but this assumption and alternative explanations remain untested.ObjectiveTo test if gray matter volume (GMV) variability is more less in later stages of schizophrenia, and evaluate if a putative ‘spreading pattern’ with GMV deficits originating in one part of the brain and diffusing elsewhere expla… Show more
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