2011
DOI: 10.1016/j.nut.2010.07.021
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Abstract: Lower brain glucose metabolism is present before the onset of clinically-measurable cognitive decline in two groups of people at risk of Alzheimer’s disease (AD) - carriers of apoE4, and in those with a maternal family history of AD. Supported by emerging evidence from in vitro and animal studies, these reports suggest that brain hypometabolism may precede and contribute to the neuropathological cascade leading cognitive decline in AD. The reason for brain hypometabolism is unclear but may include defects in g… Show more

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Cited by 474 publications
(415 citation statements)
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“…12 To assess the BBB functional integrity in APOE mice, we measured the uptake of and 5B). To determine whether the main BBB glucose transporter GLUT1 was involved, we measured by western blot GLUT1 levels in brain capillary extracts from each group.…”
Section: Reduced Transport Of [ 3 H]-d-glucose In Apoe4 Mice At 12 Momentioning
confidence: 99%
“…12 To assess the BBB functional integrity in APOE mice, we measured the uptake of and 5B). To determine whether the main BBB glucose transporter GLUT1 was involved, we measured by western blot GLUT1 levels in brain capillary extracts from each group.…”
Section: Reduced Transport Of [ 3 H]-d-glucose In Apoe4 Mice At 12 Momentioning
confidence: 99%
“…Alzheimer's disease (AD) is increasingly viewed as a disorder of brain metabolism, an invariant feature of which is a profound reduction in cerebral glucose metabolism 1, 2, 3. The impairment in glucose uptake and metabolism starts decades before classic AD symptoms and worsens steadily with disease progression 4, 5, 6.…”
Section: Introductionmentioning
confidence: 99%
“…The metabolic decline is even more rapid and profound in neurodegenerative disorders, such as Alzheimer's disease. 3 As a result, preserving brain mitochondrial integrity and metabolism with age could be critical for maintaining healthy brain function, often referred to as healthspan, and for extending lifespan. 4 Caloric restriction (CR) without malnutrition is one of several other interventions that have been introduced to preserve metabolism in aging process, and moreover CR has been shown to increase the lifespan of a broad range of species.…”
Section: Introductionmentioning
confidence: 99%