Brain dynamics predictive of response to psilocybin for treatment-resistant depression

Vohryzek, Jakub; Cabral, Joana; Lord, Louis-David; Fernandes, Henrique M; Roseman, Leor; Nutt, David; Carhart‐Harris, Robin; Deco, Gustavo; Kringelbach, Morten L.

doi:10.1101/2022.06.30.497950

Cited by 9 publications

(11 citation statements)

References 64 publications

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“…The important role of 5‐HT 2A receptor agonism in psychedelics’ mechanism of action is widely agreed upon 67–70,73,74 . Recent examination of brain regions involved in response to psilocybin‐based therapy for depression showed brain regions associated with restoration of healthy brain function to overlap significantly with 5‐HT 2A and 5‐HT 1A receptor affinity maps 75 . Research has shown dense presentation of 5‐HT 2A receptors in regions of the brain associated with music perception and music‐evoked emotion 76 .…”

Section: Common Brain Network In Music and Psychedelicsmentioning

confidence: 99%

“…[67][68][69][70]73,74 Recent examination of brain regions involved in response to psilocybin-based therapy for depression showed brain regions associated with restoration of healthy brain function to overlap significantly with 5-HT 2A and 5-HT 1A receptor affinity maps. 75 Research has shown dense presentation of 5-HT 2A receptors in regions of the brain associated with music perception and music-evoked emotion. 76 In fact, 5-HT 2A receptor signaling under LSD led to a biased neural response to music stimuli when compared to placebo as well as when compared to pretreatment with a 5-HT 2A antagonist.…”

Section: Common Brain Network In Music and Psychedelicsmentioning

confidence: 99%

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Psychedelia: The interplay of music and psychedelics

Jerotic,

Vuust,

Kringelbach

2023

Annals of the New York Academy of Sciences

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Music and psychedelics have been intertwined throughout the existence of Homo sapiens, from the early shamanic rituals of the Americas and Africa to the modern use of psychedelic‐assisted therapy for a variety of mental health conditions. Across such settings, music has been highly prized for its ability to guide the psychedelic experience. Here, we examine the interplay between music and psychedelics, starting by describing their association with the brain's functional hierarchy that is relied upon for music perception and its psychedelic‐induced manipulation, as well as an exploration of the limited research on their mechanistic neural overlap. We explore music's role in Western psychedelic therapy and the use of music in indigenous psychedelic rituals, with a specific focus on ayahuasca and the Santo Daime Church. Furthermore, we explore work relating to the evolution and onset of music and psychedelic use. Finally, we consider music's potential to lead to altered states of consciousness in the absence of psychedelics as well as the development of psychedelic music. Here, we provide an overview of several perspectives on the interaction between psychedelic use and music—a topic with growing interest given increasing excitement relating to the therapeutic efficacy of psychedelic interventions.

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Section: Common Brain Network In Music and Psychedelicsmentioning

confidence: 99%

Section: Common Brain Network In Music and Psychedelicsmentioning

confidence: 99%

Psychedelia: The interplay of music and psychedelics

Jerotic,

Vuust,

Kringelbach

2023

Annals of the New York Academy of Sciences

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“…Complimentarily, other measures describing brain states in terms of dynamical system's theory can be considered, such as the Probabilistic Metastable Substates shown to capture differences between sleep stages 36 and distinguish responders and non-responders to psilocybin treatment to depression 49 . Alternatively, novel methods from non-equilibrium and turbulent systems have been considered to further expand the notion of a brain state for future in-silico exploration for the Dynamic Sensitivity Analysis 8,50 .…”

Section: Discussionmentioning

confidence: 99%

Design of effective personalised perturbation strategies for enhancing cognitive intervention in Alzheimer’s disease

Vohryzek

Cabral

Perl

et al. 2023

Preprint

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One of the potential and promising adjuvant therapies for Alzheimer’s disease is that of non-invasive transcranial neurostimulation to potentiate cognitive training interventions. Conceptually, this is achieved by driving brain dynamics towards an optimal state for an effective facilitation of cognitive training interventions. However, current neurostimulation protocols rely on experimental trial-and-error approaches that result in variability of symptom improvements and suboptimal progress. Here, we leveraged whole-brain computational modelling by assessing the regional susceptibility towards optimal brain dynamics from Alzheimer’s disease. In practice, we followed the three-part concept of Dynamic Sensitivity Analysis by first understanding empirical differences between healthy controls and patients with mild cognitive impairment and mild dementia due to Alzheimer’s Disease; secondly, by building computational models for all individuals in the mild cognitive impairment and mild dementia cohorts; and thirdly, by perturbing brain regions and assessing the impact on the recovery of brain dynamics to the healthy state (here defined in functional terms, summarised by a measure of metastability for the healthy group). By doing so, we show the importance of key regions, along the anterior-posterior medial line, in driving in-silico improvement of mild dementia and mild cognitive impairment groups. Moreover, this subset consists mainly of regions with high structural nodal degree. Overall, this in-silico perturbational approach could inform the design of stimulation strategies for re-establishing healthy brain dynamics, putatively facilitating effective cognitive interventions targeting the cognitive decline in Alzheimer’s disease.

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“…After running the clustering for all the values of k we focused our analysis on k=3, which resulted in the minimal number of substates to reflect differences between conditions SCZ and HC. In addition, k=3 has been shown in previous research to offer a good characterisation of brain dynamics (Deco et al 2019;Escrichs et al 2022;Vohryzek et al 2022). It allows to reach a good balance between informativity and synthesis, important to increase meaningful interpretability of the results by focusing on the most relevant dynamics.…”

Section: Definition Of Probabilistic Metastable Substatesmentioning

confidence: 95%

“…To do so, we adapted a pipeline recently developed by our group (Deco et al 2019) which effectively detects critical areas involved in different altered states (Escrichs et al 2022; Vohryzek et al 2020, 2022), to investigate the mechanism of altered brain function in schizophrenia. To this aim we applied the workflow of analysis described in Fig.…”

Section: Introductionmentioning

confidence: 99%

Using in silico perturbational approach to identify critical areas in schizophrenia

Mana

Vila-Vidal

Köckeritz

et al. 2022

Preprint

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Schizophrenia is a debilitating neuropsychiatric disorder whose underlying correlates remain unclear despite decades of neuroimaging investigation. One contentious topic concerns the role of global signal fluctuations and how they affect more focal functional changes. Moreover, it has been difficult to pinpoint causal mechanisms of circuit disruption. Here we analysed resting-state fMRI data from 47 schizophrenia patients and 118 age-matched healthy controls and used dynamical analyses to investigate how global fluctuations and other functional metastable states are affected by this disorder. We then used in-silico perturbation of a whole-brain model to identify critical areas involved in the disease. We found that brain dynamics in the schizophrenic group were characterised by an increased probability of globally coherent states and reduced recurrence of a substate dominated by coupled activity in the default mode and limbic networks. Perturbing a set of temporoparietal sensory and associative areas in a model of the healthy brain reproduced global pathological dynamics. Healthy brain dynamics were instead restored by perturbing a set of medial fronto-temporal and cingulate regions in the model of pathology. These results highlight the relevance of global signal alterations in schizophrenia and identify a set of vulnerable areas involved in determining a shift in brain state.

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Brain dynamics predictive of response to psilocybin for treatment-resistant depression

Cited by 9 publications

References 64 publications

Psychedelia: The interplay of music and psychedelics

Psychedelia: The interplay of music and psychedelics

Design of effective personalised perturbation strategies for enhancing cognitive intervention in Alzheimer’s disease

Using in silico perturbational approach to identify critical areas in schizophrenia

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