2006
DOI: 10.1007/s00125-006-0537-4
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Abstract: Aims/hypothesis Decreased levels of brain-derived neurotrophic factor (BDNF) have been implicated in the pathogenesis of Alzheimer's disease and depression. These disorders are associated with type 2 diabetes, and animal models suggest that BDNF plays a role in insulin resistance. We therefore explored whether BDNF plays a role in human glucose metabolism. Subjects and methods We included (Study 1) 233 humans divided into four groups depending on presence or absence of type 2 diabetes and presence or absence o… Show more

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Cited by 565 publications
(444 citation statements)
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“…Likewise, mutations in the genes coding for BDNF and TrkB are responsible for obesity and eating disorders (Lebrun et al, 2006;Noble et al, 2011). Since lower serum or plasma BDNF levels are found in obesity (Araya et al, 2008;El-Gharbawy et al, 2006;Gray et al, 2006;Krabbe et al, 2007;Lommatzsch et al, 2005), compared to normal weight subjects, although opposite results also exist (Bus et al, 2011;Iughetti et al, 2011), our data suggest that carriers of one or two Met alleles in our study had decreased amount of the mature BDNF, possibly lower plasma BDNF levels, and therefore they had higher values of BMI and were more frequently obese. This speculation might be confirmed by the fact that weight gain, induced by antipsychotic drugs, is associated with BDNF serum levels in female schizophrenic patients, while carriers of the Met/Met genotype have lower BDNF levels than carriers of the Val allele (Zhang et al, 2008).…”
Section: Discussionmentioning
confidence: 51%
“…Likewise, mutations in the genes coding for BDNF and TrkB are responsible for obesity and eating disorders (Lebrun et al, 2006;Noble et al, 2011). Since lower serum or plasma BDNF levels are found in obesity (Araya et al, 2008;El-Gharbawy et al, 2006;Gray et al, 2006;Krabbe et al, 2007;Lommatzsch et al, 2005), compared to normal weight subjects, although opposite results also exist (Bus et al, 2011;Iughetti et al, 2011), our data suggest that carriers of one or two Met alleles in our study had decreased amount of the mature BDNF, possibly lower plasma BDNF levels, and therefore they had higher values of BMI and were more frequently obese. This speculation might be confirmed by the fact that weight gain, induced by antipsychotic drugs, is associated with BDNF serum levels in female schizophrenic patients, while carriers of the Met/Met genotype have lower BDNF levels than carriers of the Val allele (Zhang et al, 2008).…”
Section: Discussionmentioning
confidence: 51%
“…To the Editor: Krabbe et al [1] recently examined whether brain-derived neurotrophic factor (BDNF) plays a role in human glucose metabolism. By examining a large cohort of subjects with or without type 2 diabetes in the presence or absence of obesity they concluded that plasma BDNF levels were reduced in patients with type 2 diabetes and were inversely associated with fasting plasma glucose levels.…”
mentioning
confidence: 99%
“…The authors propose that decreased BDNF may be a pathogenic factor linking depression and type 2 diabetes, yet, in their study [1], they did not adequately screen their cohort for the comorbid presence of major depressive disorder (MDD). Neurotrophic factors are thought to play an important role in the aetiology of MDD [2,3].…”
mentioning
confidence: 99%
“…In a recent issue of Diabetologia Karen Krabbe et al [1] reported that low plasma levels of brain-derived neurotrophic factor (BDNF) are associated with impaired glucose metabolism in type 2 diabetes, providing a set of supporting data [1], including one of our papers demonstrating reduced plasma levels of both nerve growth factor (NGF) and BDNF in patients with acute coronary syndromes [2]. Thus, Krabbe et al concluded that decreased BDNF levels (both circulating and those released from brain) may be involved not only in the pathogenesis of dementia and depression [1], but also in diabetes.…”
Section: J F Kennedymentioning
confidence: 99%
“…Thus, Krabbe et al concluded that decreased BDNF levels (both circulating and those released from brain) may be involved not only in the pathogenesis of dementia and depression [1], but also in diabetes.…”
Section: J F Kennedymentioning
confidence: 99%