Brain-derived neurotrophic factor as a biomarker for obsessive-compulsive disorder: A meta-analysis

Hao, Lin-Shuai; Du, Yang; Chen, Lei; Jiao, Yujuan; Cheng, Yong

doi:10.1016/j.jpsychires.2022.05.026

Cited by 19 publications

(9 citation statements)

References 59 publications

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“…Indeed, induced OCD stereotypic behaviors in mice were completely reversed by BDNF infusion [149]. In correlation with this preclinical finding, a computational study reassembling results from 9 clinical studies on OCD patients demonstrated reduced levels of circulating BDNF [150]. This could be explained by an inhibition of plasminogen to plasmin conversion by tPA [55] through increased levels of PAI-1 [29].…”

Section: Obsessive-compulsive Spectrum Disordersmentioning

confidence: 58%

Glucocorticoid-Responsive Tissue Plasminogen Activator (tPA) and Its Inhibitor Plasminogen Activator Inhibitor-1 (PAI-1): Relevance in Stress-Related Psychiatric Disorders

Mennesson

Revest

2023

IJMS

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Stressful events trigger a set of complex biological responses which follow a bell-shaped pattern. Low-stress conditions have been shown to elicit beneficial effects, notably on synaptic plasticity together with an increase in cognitive processes. In contrast, overly intense stress can have deleterious behavioral effects leading to several stress-related pathologies such as anxiety, depression, substance use, obsessive-compulsive and stressor- and trauma-related disorders (e.g., post-traumatic stress disorder or PTSD in the case of traumatic events). Over a number of years, we have demonstrated that in response to stress, glucocorticoid hormones (GCs) in the hippocampus mediate a molecular shift in the balance between the expression of the tissue plasminogen activator (tPA) and its own inhibitor plasminogen activator inhibitor-1 (PAI-1) proteins. Interestingly, a shift in favor of PAI-1 was responsible for PTSD-like memory induction. In this review, after describing the biological system involving GCs, we highlight the key role of tPA/PAI-1 imbalance observed in preclinical and clinical studies associated with the emergence of stress-related pathological conditions. Thus, tPA/PAI-1 protein levels could be predictive biomarkers of the subsequent onset of stress-related disorders, and pharmacological modulation of their activity could be a potential new therapeutic approach for these debilitating conditions.

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Section: Obsessive-compulsive Spectrum Disordersmentioning

confidence: 58%

Glucocorticoid-Responsive Tissue Plasminogen Activator (tPA) and Its Inhibitor Plasminogen Activator Inhibitor-1 (PAI-1): Relevance in Stress-Related Psychiatric Disorders

Mennesson

Revest

2023

IJMS

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“…Furthermore, the BDNF literature is vast and spans other domains outside of the sensorimotor system. In particular, there is literature identifying that BDNF plays a role in aging, neurodegeneration, mental disorders, and other domains [ 61 , 62 , 63 ]. Therefore, it is possible that BDNF also affects the aging population in CP or influences the well-known cognitive impairments [ 64 , 65 ].…”

Section: Discussionmentioning

confidence: 99%

A Val66Met polymorphism is associated with weaker somatosensory cortical activity in individuals with cerebral palsy

Trevarrow

Sanmann

Wilson

et al. 2022

Heliyon

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“…It is located in the region of human chromosome 11 p13-14 encoded by the BDNF gene. [78][79][80] BDNF has two active forms: the precursor form ( pro-BDNF) and the mature form (mBDNF), which act in opposite ways. Also, BDNF has two receptors.…”

Section: Bdnfmentioning

confidence: 99%

Ginsenosides can target brain-derived neurotrophic factor to improve Parkinson's disease

et al. 2023

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Brain-derived neurotrophic factor as a biomarker for obsessive-compulsive disorder: A meta-analysis

Cited by 19 publications

References 59 publications

Glucocorticoid-Responsive Tissue Plasminogen Activator (tPA) and Its Inhibitor Plasminogen Activator Inhibitor-1 (PAI-1): Relevance in Stress-Related Psychiatric Disorders

Glucocorticoid-Responsive Tissue Plasminogen Activator (tPA) and Its Inhibitor Plasminogen Activator Inhibitor-1 (PAI-1): Relevance in Stress-Related Psychiatric Disorders

A Val66Met polymorphism is associated with weaker somatosensory cortical activity in individuals with cerebral palsy

Ginsenosides can target brain-derived neurotrophic factor to improve Parkinson's disease

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