Brain bank of the Brazilian aging brain study group—a milestone reached and more than 1,600 collected brains

Grinberg, Lea T.; Ferretti, Renata Eloah de Lucena; Farfel, José Marcelo; Leite, Renata; Pasqualucci, Carlos Augusto; Rosemberg, Sérgio; Nitrini, Ricardo; Saldiva, Paulo Hilário Nascimento; Filho, Wilson Jacob

doi:10.1007/s10561-006-9022-z

Cited by 138 publications

(175 citation statements)

References 33 publications

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“…The BB-BABSG is a tissue bank and its procedure has been approved by local ethical committee (N o 458.272) and described elsewhere (17)(18) . The study was approved by the Research Ethics Committee for the Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (N o 942/04).…”

Section: Study Design and Source Of Casesmentioning

confidence: 99%

Validity of the Katz Index to assess activities of daily living by informants in neuropathological studies

Ferretti-Rebustini

Balbinotti

Jacob‐Filho

et al. 2015

Rev. esc. enferm. USP

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Objective:To analyze the evidences of construct validity of the Katz Index for the retrospective assessment of activities of daily living (ADL) by informants, to assist neuropathological studies in the elderly. Method: A cross-sectional study analyzed the functional ability of ADL measure by the Katz Index, of 650 cases randomly selected from the Brazilian Brain Bank of the Ageing Brain Study Group (BBBABSG) database. Sample was divided in two subsamples for the analysis (N=325, each) and then stratified according to cognitive decline assessed by the Clinical Dementia Rating Scale (CDR). Factor analyses with calculations of internal consistency and invariance were performed. Results: Factor analysis evidenced a unidimensional instrument with optimal internal consistency, in all subgroups. Goodness of fit indices were obtained after two treatments of covariance, indicating adequacy of the scale for assessing ADL by informants. The scale is invariant to cognitive decline meaning that it can be used for subjects with or without cognitive impairment. Conclusion: Katz Index is valid for the retrospective assessment of basic ADL by informants, with optimal reliability.

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Section: Study Design and Source Of Casesmentioning

confidence: 99%

Validity of the Katz Index to assess activities of daily living by informants in neuropathological studies

Ferretti-Rebustini

Balbinotti

Jacob‐Filho

et al. 2015

Rev. esc. enferm. USP

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“…Inclusion and exclusion criteria for the BABSG were previously described. 15 From February 2004 to February 2009, a total of 1,980 persons aged 50 years or older were included in the BABSG. Of these, the first consecutive 675 persons underwent a complete clinical and neuropathologic diagnosis and were included in this study.…”

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confidence: 99%

“…Selected sections were immunostained with antibodies against b-amyloid (4G8, dilution 1:10.000; Signet Pathology Systems, Dedham, MA), against phospho-tau (PHF-1, dilution 1:2.000; gift of Prof. Peter Davies, NY), and against a-synuclein (EQV-1, 1:10.000; gift of Kenji Ueda, Tokyo, Japan), as described previously. 15 All sections were submitted to antigenic retrieval using a steamer. The reactions were detected using the Vectastain Elite ABC Kit (Vector Laboratories, Burlingame, CA).…”

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confidence: 99%

Very low levels of education and cognitive reserve

Farfel

Nitrini²,

Suemoto³

et al. 2013

Neurology

145

114

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Objective: We conducted a clinicopathologic study in a large population with very low levels of education to determine whether very few years of education could contribute to cognitive reserve and modify the relation of neuropathologic indices to dementia. Methods:In this cross-sectional study, we included 675 individuals 50 years of age or older from the Brazilian Aging Brain Study Group. Cognitive abilities were evaluated through a structured interview with an informant at the time of autopsy, including the Clinical Dementia Rating (CDR) scale. Neuropathologic examinations were performed using immunohistochemistry and following internationally accepted criteria. Multivariate linear regression models were conducted to determine whether the association between cognitive abilities (measured by CDR sum of boxes) and years of education was independent of sociodemographic variables and neuropathologic indices, including neuritic plaques, neurofibrillary tangles, lacunar infarctions, small-vessel disease, and Lewy bodies. In addition, interaction models were used to examine whether education modified the relation between neuropathologic indices and cognition.Results: Mean education was 3.9 6 3.5 years. The cognitive reserve theory is increasingly used to explain the clinicopathologic dissociation observed in Alzheimer disease (AD). 1 Approximately 30% of cognitively normal subjects have intermediate-to high-likelihood AD pathology at autopsy. [2][3][4][5][6][7] According to this theory, subjects with greater cognitive reserve require a more severe neuropathologic burden to reach the threshold for clinical dementia. 8 Previous clinicopathologic studies suggest that although education is not directly related to the development of neuropathologic lesions, it appears to reduce the impact of such lesions on the development of dementia, thereby increasing cognitive reserve. However, the studies supporting this hypothesis have investigated populations with relatively high levels of educational attainment, with mean formal education ranging from 9 to 18 years. [8][9][10][11][12] Little information is available regarding the effect of very few years of education on cognitive reserve. Low educational attainment is the reality for a high proportion of the elderly worldwide. According to a report from the United Nations Education, Scientific and Cultural Organization, nearly 800 million adults remained illiterate in 2009, representing about 16% of the global population. 13 Most of

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“…The methods whereby fresh brains or parts are being frozen are diverse, which further complicates the interpretation of data and comparison of results [Gsell, et al, 1993, Duyckaerts, et al, 1993, Newcombe, et al, 1993, Hulette, et al, 1997, Hulette, 2003, Schmitt, et al, 2007, Vonsattel, et al, 1995, Grinberg, et al, 2007, Vonsattel, et al, 2008.…”

Section: Fresh Frozen Brain Samplesmentioning

confidence: 99%

Twenty-first century brain banking: practical prerequisites and lessons from the past: the experience of New York Brain Bank, Taub Institute, Columbia University

Vonsattel

Amaya

Cortés

et al. 2008

Cell Tissue Banking

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Generally accepted methods for processing postmortem brains are lacking despite the efforts of pioneers in the field, and the growing awareness of the importance of brain banking for investigating the pathogenesis of illnesses unique to humans. Standardizing methods require compromises, institutional or departmental mindset promoting collaboration, and willingness for sharing ideas, information, and samples. A sound balance between competition and institutional interests is needed to best fulfill the tasks entrusted to health care institutions. Thus, a potentially widely accepted protocol design involves tradeoffs.We successfully integrated brain banking within the operation of the department of pathology. We reached a consensus whereby a brain can be utilized for diagnosis, research, and teaching. Thus, routing brains away from residency programs is avoided. The best diagnostic categorization possible is being secured and the yield of samples for research maximized.Thorough technical details pertaining to the actual processing of brains donated for research was recently published. Briefly, one-half of each brain is immersed in formalin for performing the neuropathologic evaluation, which is combined with the teaching task. The contralateral half is extensively dissected at the fresh state to obtain samples ready for immediate disbursement once categorized diagnostically. The samples are tracked electronically, which is crucial. This important tracking system is described separately. This report focuses on key lessons learned over the past 25 years of brain banking including successful solutions to originally unforeseen problems.

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Brain bank of the Brazilian aging brain study group—a milestone reached and more than 1,600 collected brains

Cited by 138 publications

References 33 publications

Validity of the Katz Index to assess activities of daily living by informants in neuropathological studies

Validity of the Katz Index to assess activities of daily living by informants in neuropathological studies

Very low levels of education and cognitive reserve

Twenty-first century brain banking: practical prerequisites and lessons from the past: the experience of New York Brain Bank, Taub Institute, Columbia University

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