Brain Abscesses: Etiologic Categorization with in Vivo Proton MR Spectroscopy

Abstract

It is possible to differentiate anaerobic from aerobic or sterile brain abscesses on the basis of metabolite patterns observed at in vivo proton MR spectroscopy. This information may be useful in facilitating prompt and appropriate treatment of patients with these abscesses.

In Vivo Proton MR Spectroscopy Evaluation of Pyogenic Brain Abscesses: A Report of 194 Cases

“…28 Suc and Ac are usually not observed in brain abscesses secondary to aerobic (Fig 4) and facultative anaerobic microorganisms because the pyruvate formed during glycolysis enters the tricarboxylic acid cycle in these bacteria in the presence of oxygen. 8 In accord with the literature, we did not observe these resonances in any of the aerobic brain abscesses. 8 However, we found these resonances in 11 patients demonstrating facultative anaerobes (Fig 5) on culture:…”

“…8 In accord with the literature, we did not observe these resonances in any of the aerobic brain abscesses. 8 However, we found these resonances in 11 patients demonstrating facultative anaerobes (Fig 5) on culture:…”

In Vivo Proton MR Spectroscopy Evaluation of Pyogenic Brain Abscesses: A Report of 194 Cases

“…28 Suc and Ac are usually not observed in brain abscesses secondary to aerobic (Fig 4) and facultative anaerobic microorganisms because the pyruvate formed during glycolysis enters the tricarboxylic acid cycle in these bacteria in the presence of oxygen. 8 In accord with the literature, we did not observe these resonances in any of the aerobic brain abscesses. 8 However, we found these resonances in 11 patients demonstrating facultative anaerobes (Fig 5) on culture:…”

“…8 In accord with the literature, we did not observe these resonances in any of the aerobic brain abscesses. 8 However, we found these resonances in 11 patients demonstrating facultative anaerobes (Fig 5) on culture:…”

Imaging Diagnosis—conventional and Functional Magnetic Resonance Imaging of a Brain Abscess in a Goat

“…Under abnormal conditions, other metabolites may be identified and the spectroscopy pattern may help to differentiate between different diseases, such as abscess or tumor formation . The spectroscopy pattern of an abscess with involvement of facultative anaerobic Trueperella pyogenes reported here, documenting increased amounts of amino acids, acetate, succinate, and lipids is in agreement with previously reported anaerobic abscesses in people . The spectra of intracranial abscesses reported in people can be summarized as follows: absence of NAA and Cho, presence of cytosolic amino acids (isoleucine, valine, and leucine resonating together at 0.9 ppm), and presence of acetate and succinate in anaerobic abscesses.…”

Feasibility of magnetic resonance electrical impedance tomography (MREIT) conductivity imaging to evaluate brain abscess lesion:In vivocanine model

“…In differentiating brain abscesses from other brain diseases, diffusion‐weighted imaging (DWI) and 1 H MR spectroscopy ( 1 H MRS) are useful as additional imaging techniques . However, there are some conflicting reports in the literature regarding DWI, so the combination of 1 H MRS and DWI may improve results compared with the use of only a single technique . In our results, unique time‐course variations of rCCR values in the abscess lesion represent that present MREIT conductivity images of abscess reflects the tissue condition according to the growth of brain abscess.…”

In Vivo Proton MR Spectroscopy Evaluation of Pyogenic Brain Abscesses: A Report of 194 Cases

“…28 Suc and Ac are usually not observed in brain abscesses secondary to aerobic (Fig 4) and facultative anaerobic microorganisms because the pyruvate formed during glycolysis enters the tricarboxylic acid cycle in these bacteria in the presence of oxygen. 8 In accord with the literature, we did not observe these resonances in any of the aerobic brain abscesses. 8 However, we found these resonances in 11 patients demonstrating facultative anaerobes (Fig 5) on culture:…”

“…8 In accord with the literature, we did not observe these resonances in any of the aerobic brain abscesses. 8 However, we found these resonances in 11 patients demonstrating facultative anaerobes (Fig 5) on culture:…”

Imaging Diagnosis—conventional and Functional Magnetic Resonance Imaging of a Brain Abscess in a Goat

“…Under abnormal conditions, other metabolites may be identified and the spectroscopy pattern may help to differentiate between different diseases, such as abscess or tumor formation . The spectroscopy pattern of an abscess with involvement of facultative anaerobic Trueperella pyogenes reported here, documenting increased amounts of amino acids, acetate, succinate, and lipids is in agreement with previously reported anaerobic abscesses in people . The spectra of intracranial abscesses reported in people can be summarized as follows: absence of NAA and Cho, presence of cytosolic amino acids (isoleucine, valine, and leucine resonating together at 0.9 ppm), and presence of acetate and succinate in anaerobic abscesses.…”

Feasibility of magnetic resonance electrical impedance tomography (MREIT) conductivity imaging to evaluate brain abscess lesion:In vivocanine model

“…In differentiating brain abscesses from other brain diseases, diffusion‐weighted imaging (DWI) and 1 H MR spectroscopy ( 1 H MRS) are useful as additional imaging techniques . However, there are some conflicting reports in the literature regarding DWI, so the combination of 1 H MRS and DWI may improve results compared with the use of only a single technique . In our results, unique time‐course variations of rCCR values in the abscess lesion represent that present MREIT conductivity images of abscess reflects the tissue condition according to the growth of brain abscess.…”

In Vivo Proton MR Spectroscopy Evaluation of Pyogenic Brain Abscesses: A Report of 194 Cases

“…28 Suc and Ac are usually not observed in brain abscesses secondary to aerobic (Fig 4) and facultative anaerobic microorganisms because the pyruvate formed during glycolysis enters the tricarboxylic acid cycle in these bacteria in the presence of oxygen. 8 In accord with the literature, we did not observe these resonances in any of the aerobic brain abscesses. 8 However, we found these resonances in 11 patients demonstrating facultative anaerobes (Fig 5) on culture:…”

“…8 In accord with the literature, we did not observe these resonances in any of the aerobic brain abscesses. 8 However, we found these resonances in 11 patients demonstrating facultative anaerobes (Fig 5) on culture:…”

Imaging Diagnosis—conventional and Functional Magnetic Resonance Imaging of a Brain Abscess in a Goat

“…Under abnormal conditions, other metabolites may be identified and the spectroscopy pattern may help to differentiate between different diseases, such as abscess or tumor formation . The spectroscopy pattern of an abscess with involvement of facultative anaerobic Trueperella pyogenes reported here, documenting increased amounts of amino acids, acetate, succinate, and lipids is in agreement with previously reported anaerobic abscesses in people . The spectra of intracranial abscesses reported in people can be summarized as follows: absence of NAA and Cho, presence of cytosolic amino acids (isoleucine, valine, and leucine resonating together at 0.9 ppm), and presence of acetate and succinate in anaerobic abscesses.…”

Feasibility of magnetic resonance electrical impedance tomography (MREIT) conductivity imaging to evaluate brain abscess lesion:In vivocanine model

“…In differentiating brain abscesses from other brain diseases, diffusion‐weighted imaging (DWI) and 1 H MR spectroscopy ( 1 H MRS) are useful as additional imaging techniques . However, there are some conflicting reports in the literature regarding DWI, so the combination of 1 H MRS and DWI may improve results compared with the use of only a single technique . In our results, unique time‐course variations of rCCR values in the abscess lesion represent that present MREIT conductivity images of abscess reflects the tissue condition according to the growth of brain abscess.…”