Brain 5-HT1C receptors and antidepressants

Antidepressant-like effects of agomelatine (S 20098) in the learned helplessness model

“…These results are in agreement with data from the literature showing that the 5-HT 2C antagonist property, shared by a number of other clinically active antidepressant agents of different classes (Bakish et al, 1993;Jenck et al, 1994;Ni and Miledi, 1997;Stefanski and Goldberg, 1997;Millan et al, 2000), cannot by itself support their full antidepressant-like activity.…”

Antidepressant-like effects of agomelatine (S 20098) in the learned helplessness model

“…These results are in agreement with data from the literature showing that the 5-HT 2C antagonist property, shared by a number of other clinically active antidepressant agents of different classes (Bakish et al, 1993;Jenck et al, 1994;Ni and Miledi, 1997;Stefanski and Goldberg, 1997;Millan et al, 2000), cannot by itself support their full antidepressant-like activity.…”

Role of Serotonin in Central Dopamine Dysfunction

“…This hypothesis is consistent with the suggestion that 5-HT 2C receptor blockers might exert antidepressant activity [27,29,[34][35][36][37]. In this respect, it is interesting to note that several antidepressant drugs have been shown to bind with submicromolar affinity to 5-HT 2C receptors in the pig brain and to antagonize mCPP-induced penile erections in rats, an effect mediated through the stimulation of central 5-HT 2C receptors [37][38][39]. Based on those findings, Matteo et al [34] have carried out experiments showing that acute administration of amitriptyline and mianserin, two antidepressants with high affinity for 5-HT 2C receptors, enhances DA release in the rat nucleus accumbens by blocking these receptor subtypes, in addition to their other pharmacological properties.…”

Central Serotonin2C Receptor: From Physiology to Pathology

“…This hypothesis is consistent with the evidence that some antidepressant drugs display prominent 5-HT 2C receptor binding, e.g. tricyclics (amitriptyline, imipramine), mianserin, nefazodone, opipramole, trazodone [67,152,153] and fluoxetine [148,154]. Based on those findings, Di Matteo and colleagues [155] have carried out experiments showing that acute administration of amitriptyline and mianserin enhances DA release in the rat nucleus accumbens by blocking 5-HT 2C receptor subtypes.…”

Antidepressant-like effects of agomelatine (S 20098) in the learned helplessness model

“…These results are in agreement with data from the literature showing that the 5-HT 2C antagonist property, shared by a number of other clinically active antidepressant agents of different classes (Bakish et al, 1993;Jenck et al, 1994;Ni and Miledi, 1997;Stefanski and Goldberg, 1997;Millan et al, 2000), cannot by itself support their full antidepressant-like activity.…”

Role of Serotonin in Central Dopamine Dysfunction

“…This hypothesis is consistent with the suggestion that 5-HT 2C receptor blockers might exert antidepressant activity [27,29,[34][35][36][37]. In this respect, it is interesting to note that several antidepressant drugs have been shown to bind with submicromolar affinity to 5-HT 2C receptors in the pig brain and to antagonize mCPP-induced penile erections in rats, an effect mediated through the stimulation of central 5-HT 2C receptors [37][38][39]. Based on those findings, Matteo et al [34] have carried out experiments showing that acute administration of amitriptyline and mianserin, two antidepressants with high affinity for 5-HT 2C receptors, enhances DA release in the rat nucleus accumbens by blocking these receptor subtypes, in addition to their other pharmacological properties.…”

Central Serotonin2C Receptor: From Physiology to Pathology

“…This hypothesis is consistent with the evidence that some antidepressant drugs display prominent 5-HT 2C receptor binding, e.g. tricyclics (amitriptyline, imipramine), mianserin, nefazodone, opipramole, trazodone [67,152,153] and fluoxetine [148,154]. Based on those findings, Di Matteo and colleagues [155] have carried out experiments showing that acute administration of amitriptyline and mianserin enhances DA release in the rat nucleus accumbens by blocking 5-HT 2C receptor subtypes.…”

Antidepressant-like effects of agomelatine (S 20098) in the learned helplessness model

“…These results are in agreement with data from the literature showing that the 5-HT 2C antagonist property, shared by a number of other clinically active antidepressant agents of different classes (Bakish et al, 1993;Jenck et al, 1994;Ni and Miledi, 1997;Stefanski and Goldberg, 1997;Millan et al, 2000), cannot by itself support their full antidepressant-like activity.…”

Role of Serotonin in Central Dopamine Dysfunction

“…This hypothesis is consistent with the suggestion that 5-HT 2C receptor blockers might exert antidepressant activity [27,29,[34][35][36][37]. In this respect, it is interesting to note that several antidepressant drugs have been shown to bind with submicromolar affinity to 5-HT 2C receptors in the pig brain and to antagonize mCPP-induced penile erections in rats, an effect mediated through the stimulation of central 5-HT 2C receptors [37][38][39]. Based on those findings, Matteo et al [34] have carried out experiments showing that acute administration of amitriptyline and mianserin, two antidepressants with high affinity for 5-HT 2C receptors, enhances DA release in the rat nucleus accumbens by blocking these receptor subtypes, in addition to their other pharmacological properties.…”

Central Serotonin2C Receptor: From Physiology to Pathology

“…This hypothesis is consistent with the evidence that some antidepressant drugs display prominent 5-HT 2C receptor binding, e.g. tricyclics (amitriptyline, imipramine), mianserin, nefazodone, opipramole, trazodone [67,152,153] and fluoxetine [148,154]. Based on those findings, Di Matteo and colleagues [155] have carried out experiments showing that acute administration of amitriptyline and mianserin enhances DA release in the rat nucleus accumbens by blocking 5-HT 2C receptor subtypes.…”