BRAF V600E positive papillary thyroid carcinoma is associated with suspicious ultrasound features

Sastre-Marcos, Júlia; Val-Zaballos, Florentino Del; Cortes-Munoz, Claudia; Campos-Martín, Yolanda; Aso-Manso, Sonsoles; Jaen-Diaz, Ignacio; Vicente-Delgado, Almudena; López‐López, José

doi:10.1530/endoabs.37.ep850

Cited by 2 publications

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“…Cong et al (22) reported that the BRAFV600E mutation was associated with the blood flow signal in ultrasound, while Kabaker et al (23) identified an association between the BRAFV600E mutation and the boundary, aspect ratio and microcalcification of thyroid nodules upon ultrasound. Sastre-Marcos et al (24) reported an association between the BRAFV600E mutation with at least one of the ultrasound features, and microcalcification and hypoechogenicity were two independently associated factors. Luo et al (25) reported that the BRAFV600E mutation was associated with the features of the nodules on elastography, but not with the features on 2-dimensional ultrasound.…”

Section: Discussionmentioning

confidence: 99%

Association analysis and the clinical significance of BRAF gene mutations and ultrasound features in papillary thyroid carcinoma

Liu

He²,

Yin

et al. 2019

Oncol Lett

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The aim of the present study was to evaluate the associations between the B-Raf proto-oncogene serine/threonine kinase (BRAF)V600E mutation and conventional and contrast-enhanced ultrasonographic features in patients with papillary thyroid carcinoma (PTC), and to subsequently investigate the clinical value of these associations. In total, 207 thyroid nodules (diameter ≤2 cm) were selected. Conventional ultrasound, contrast-enhanced ultrasound, BRAFV600E mutational analysis and ultrasound-guided fine-needle aspiration biopsy were preoperatively performed, and histopathological assessment of PTC was postoperatively confirmed. The nodules were divided into 2 groups based on the BRAFV600E mutational analysis, namely the mutant or the wild-type variant groups, and the association analyses of the ultrasonographic features between these 2 groups were performed. Overall, 74.9% (155/207) of the PTC nodules had the BRAFV600E mutation, while 25.1% (52/207) had the wild-type BRAF allele. The 2 groups were analyzed using univariate logistic regression analysis, which demonstrated no significant differences regarding morphology, boundary, hypoechogenicity of the nodules, blood flow signal, enhancement uniformity, enhancement degree and clearance time (P>0.05). Moreover, the 2 groups demonstrated significant differences regarding the aspect ratio, microcalcification, nodule size following enhancement, enhancement mode and enhancement time (P<0.05). A multivariate logistic regression analysis was performed to further validate the association of these features with the BRAFV600E mutation; however, only microcalcification [odds ratio (OR), 2.256; 95% confidence interval (CI), 1.160–5.500; P=0.020] and nodule size following enhancement (OR, 2.119; 95% CI, 1.039–4.321; P=0.039) were associated with the BRAF mutational status. The associations found between the two ultrasonographic features and BRAFV600E mutation indicate that they can predict the BRAF mutational status to provide a reliable basis for clinical diagnosis and treatment.

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Section: Discussionmentioning

confidence: 99%

Association analysis and the clinical significance of BRAF gene mutations and ultrasound features in papillary thyroid carcinoma

Liu

He²,

Yin

et al. 2019

Oncol Lett

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“…For instance, Kabaker et al (2012) found that BRAF mutations were linked to the border of the thyroid nodule, the aspect ratio, and microcalcification. Sastre-Marcos (2015) reported that microcalcification and hypoechogenicity were found to be two independent factors correlated with BRAF mutations. Our results were consistent with their findings, with microcalcification, hypoechogenicity, lobulated margins, and an aspect ratio of greater than 1 being independent risk factors for BRAF mutations.…”

Section: Discussionmentioning

confidence: 99%

Construction and validation of BRAF mutation diagnostic model based on ultrasound examination and clinical features of patients with thyroid nodules

Fang

et al. 2022

Front. Genet.

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Introduction: Fine Needle Aspiration (FNA) is currently the most popular method for identifying benign and malignant thyroid nodules. However, its diagnostic sensitivity is sometimes limited, which makes it necessary to apply genetic testing and other modalities as a secondary diagnostic method. The diagnostic accuracy of thyroid nodule can be improved by combining mutations in the B-Raf proto-oncogene serine/threonine kinase (BRAF) with FNA. Thus, this study was conducted to create a nomogram diagnostic model based on the clinical and ultrasonic characteristics of patients with BRAF mutations to aid in the identification of benign and malignant thyroid nodules using FNA.Methods: From April 2018 to December 2021, 275 patients with thyroid nodules who underwent ultrasonography and BRAF gene testing (137 positive and 138 negative) were included from Xianyang Central Hospital. The clinical and ultrasonic characteristics of the patients were used to develop a nomographic, diagnostic model of BRAF gene mutation, and to validate and evaluate the usefulness of the model.Results: Independent risk factors for BRAF mutations included: focal strong echogenicity (microcalcifications, OR = 3.04, 95%CI = 1.41–6.58, p = 0.005), hypoechogenicity (OR = 3.8, 95%CI = 1.14–12.61, p = 0.029), lymph node metastases (OR = 3.54, 95%CI = 1.43–8.75, p = 0.006), margin (lobulated, OR = 3.7, 95%CI = 1.66–8.23, p = 0.001; extrathyroidal invasion, OR = 2.81, 95%CI = 1.11–7.06, p = 0.029), and shape (vertical position, OR = 2.7, 95%CI = 1.11–6.59, p = 0.029). The area under the curve (AUC) of the receiver operating characteristic (ROC) curve of the BRAF mutation diagnostic model constructed on these factors was 0.806 (95% CI = 0.754–0.851), and 39.5% was set as the threshold probability of making a clinical decision. The results of the validation and clinical utility evaluation showed that our model had good predictive performance and clinical application value.Conclusion: Our nomogram diagnostic model based on clinical and ultrasound features of patients accurately predicted the possibility of BRAF gene mutations in patients with thyroid nodules.

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BRAF V600E positive papillary thyroid carcinoma is associated with suspicious ultrasound features

Cited by 2 publications

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Association analysis and the clinical significance of BRAF gene mutations and ultrasound features in papillary thyroid carcinoma

Association analysis and the clinical significance of BRAF gene mutations and ultrasound features in papillary thyroid carcinoma

Construction and validation of BRAF mutation diagnostic model based on ultrasound examination and clinical features of patients with thyroid nodules

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