Biochemical Pharmacology volume 80, issue 5, P561-567 2010 DOI: 10.1016/j.bcp.2010.03.019 View full text
Claudia Wellbrock, Adam Hurlstone

Abstract: BRAF is a member of the RAF kinase family, which acts in the ERK/MAP kinase pathway, a signalling cascade that regulates cellular proliferation, differentiation and survival. Single point mutations can turn BRAF into an oncogene, but there appears to be a cell type/tumour specific relevance for BRAF kinase-activating mutations, since they are found predominantly in cutaneous melanoma. With the success of targeting other oncogenic kinases such as BCR-ABL, KIT or members of the epidermal-growth factor receptor (…

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