Brachial Plexopathy

Khadilkar, Satish V; Yadav, Rakhil S.; Patel, Bhagyadhan A.

doi:10.1007/978-981-10-5361-0_31

Cited by 3 publications

(5 citation statements)

References 20 publications

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“…13,14 Neoplastic plexopathies more commonly present with pain, whereas radiation-associated plexopathies more commonly present with paresthesias and weakness. [15][16][17] The frequency of neoplastic brachial plexopathy in cancer patients is estimated to be 0.43% in one study, with the most common primary tumors being of breast or lung in origin. 13 MRI is the preferred imaging modality in these patients, and electrodiagnostic testing is often a helpful adjunct; these results are correlated with functional deficits on clinical exam to localize the lesion.…”

Section: Discussionmentioning

confidence: 99%

Occult primary breast cancer presenting with brachial plexopathy: A case report

Zhao

Liu

Scherpelz

et al. 2021

SAGE Open Medical Case Reports

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Breast cancer affects about one in eight women over the course of her lifetime. Occult breast cancer, in which primary breast cancer is detected without evidence of disease in the breast itself, comprises up to 1% of new diagnoses; this is typically detected from abnormal axillary lymph nodes, and distant metastases are rare. Here, we present an unusual case of occult breast cancer presenting as upper extremity pain, edema, and weakness, with a metastatic mass to the brachial plexus being the only site of disease.

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Section: Discussionmentioning

confidence: 99%

Occult primary breast cancer presenting with brachial plexopathy: A case report

Zhao

Liu

Scherpelz

et al. 2021

SAGE Open Medical Case Reports

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“…Idiopathic brachial neuritis is most commonly asymmetric (bilateral in 1/3 of cases [ 58 ]) and affects men more than women at a rate of at least 2:1 [ 49 ]. The condition typically has a bimodal age distribution, occurring most commonly in patients in their 20s and 60s [ 58 ].…”

Section: Pathogenesismentioning

confidence: 97%

“…The condition typically has a bimodal age distribution, occurring most commonly in patients in their 20s and 60s [ 58 ]. Approximately half of patients report preceding events such as fl u-like symptoms [ 59 ], recent vaccination [ 61 , 62 ], and/or recent surgery [ 63 ] in the days just prior to the onset of symptoms, leading some to believe the condition may be immune-modulated [ 58 ].…”

Section: Pathogenesismentioning

confidence: 99%

“…Hereditary brachial neuritis is a rare autosomal dominant condition that, unlike other forms of brachial neuritis, generally manifests in early childhood with dysmorphic phenotypes such as hypotelorism, facial asymmetry, and/or cleft palate, among others [ 58 ]. It is associated with missense mutations and heterogeneous duplications of the SEPT9 gene on chromosome 17q25 and its prevalence is largely unknown [ 75 , 76 ].…”

Section: Pathogenesismentioning

confidence: 99%

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Neurovascular Disorders

Warth

Millett

2015

Physical Examination of the Shoulder

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“…3 Neuralgic amyotrophy (NA), or Parsonage-Turner syndrome/brachial neuritis, is characterised by male predisposition, severe pain and limb weakness in the 3rd to 7th decade of life. 4 It has rarely been reported in COVID-19 infections or within 6 weeks of vaccination. 5 Hypothesised causes focus on immune-mediated processes, 3 although the underlying pathophysiology remains unclear.…”

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confidence: 99%

Neuralgic amyotrophy in COVID-19 infection and after vaccination

Chiew

Kong

et al. 2022

Ann Acad Med Singap

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Neuralgic amyotrophy in COVID-19 infection and after vaccinationLETTER TO THE EDITOR Dear Editor, Various neurological manifestations associated with coronavirus disease 2019 (COVID-19) have been described, 1 conditions which left a significant proportion of patients with permanent disability. Continued vigilance is crucial with emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants that cause the disease. Vaccination against COVID-19 remains the key strategy to reduce disease severity and transmission. 2 However, the novel mRNA technology and reports of neurological adverse effects raise concerns about COVID-19 vaccine safety, especially since multiple doses are needed to combat the waning immunity of such vaccines. 3 Neuralgic amyotrophy (NA), or Parsonage-Turner syndrome/brachial neuritis, is characterised by male predisposition, severe pain and limb weakness in the 3rd to 7th decade of life. 4 It has rarely been reported in COVID-19 infections or within 6 weeks of vaccination. 5 Hypothesised causes focus on immune-mediated processes, 3 although the underlying pathophysiology remains unclear. With the COVID-19 pandemic, the challenge lies in differentiating the trigger for NA in vaccinated individuals who develop breakthrough COVID-19 infections. Comparisons of disease characteristics in COVID-19 patients with those occurring after COVID-19 vaccinations may shed some light, but such data are lacking. We illustrate a case and review the literature by searching PubMed, Embase and Google Scholar from 1 December 2019 to 30 November 2021 using the following keywords: "Parsonage-Turner Syndrome", "brachial plexopathy", "brachial neuritis", "brachial plexitis", "neuralgic amyotrophy", "SARS-CoV-2" and "COVID-19". We analysed cases with confirmed COVID-19 (World Health Organization guidelines) 6 occurring in symptomatic individuals and in those presenting within 6 weeks of COVID-19 vaccination (time frame conventionally used to study vaccine-related adverse events). 7 Cases with inadequate data, unclear temporality and non-English reports were excluded. The study was approved by the Singapore Health Services institutional review board (CIRB 2020/2410), and waiver of consent was granted.A 34-year-old healthy man presented on day 4 of symptomatic COVID-19 with a 3-day history of shoulder pain, weakness and numbness of the left upper limb. There was no trauma, recent neck manipulation nor other constitutional symptoms. He had received the

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Brachial Plexopathy

Cited by 3 publications

References 20 publications

Occult primary breast cancer presenting with brachial plexopathy: A case report

Occult primary breast cancer presenting with brachial plexopathy: A case report

Neurovascular Disorders

Neuralgic amyotrophy in COVID-19 infection and after vaccination

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