Bowenoid papulosis. Presence of human papillomavirus (HPV) structural antigens and of HPV 16-related DNA sequences

Gross, Gerd; Hagedorn, Manfred; Ikenberg, Hans; Rufli, T; Dahlet, Catherine; Grosshans, É; Gissmann, Lutz

doi:10.1001/archderm.121.7.858

Cited by 80 publications

(44 citation statements)

References 13 publications

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“…There were no histologic differences between those lesions that contained papillomavirus cap sid antigen and those that did not. The relatively uniform distribution of genitally located Bowen's disease over the whole age range is another interesting finding of our study because it indicates that Bowen's disease of the genitalia is not necessarily a disor der in young, sexually active persons, as has been reported in the literature [15].…”

Section: Discussionsupporting

confidence: 79%

“…Most of the published immunologic studies were per formed on genitally located Bowen's disease: Braun et al [14] detected papillomavirus capsid antigen in 2 of 21 cases of bowenoid papulosis, Gross et al [15] in 2 of 39 cases, Guillet et al [16] in 1 of 2, Poffet et al [ 17] in 2 of 3 and Penncys et al 118] in 13 of 18 lesions. These different detection rates may be due either to sampling error or to the inherent test sensitivity.…”

Section: Discussionmentioning

confidence: 99%

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Papillomavirus Common Antigen in Bowen’s Disease

Grussendorf-Conen¹,

Giesen²

1990

Dermatology

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We studied 173 biopsies of histologically determined Bowen’s disease and looked for the presence of papillomavirus antigen using immunoperoxidase staining. Fifty-nine of the lesions were located at the head, 49 at the extremities, 36 at the trunk and 29 originated from the genital region. Papillomavirus capsid antigen could be clearly identified in 39 (22.5%) cases. Eleven (38%) of the 29 lesions located on genital skin were positive for papillomavirus capsid antigen while 28 (19.4%) of the 144 biopsies from other skin regions contained viral antigen. Our findings are suggestive of an etiologic relationship between the virus and this dermatosis which represents a special variant of squamous cell carcinoma. They indicate that human papillomaviruses may play an important role in the development of cutaneous malignancies.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Papillomavirus Common Antigen in Bowen’s Disease

Grussendorf-Conen¹,

Giesen²

1990

Dermatology

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“…It is now generally accepted that HPV 16 is the causative agent for Bowenoid papulosis. 16 We describe four men with bowenoid papulosis. Each case was resistant to multiple methods of therapy.…”

mentioning

confidence: 97%

Immunosuppression in Men With Bowenoid Papulosis

Feldman¹

1989

Arch Dermatol

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The immune status of four men with bowenoid papulosis was evaluated. Each case had been refractory to multiple methods of treatment. Three of the men had other infections and demonstrated a depletion of T4-helper cells. Two of these patients were anergic on skin testing, and the third showed weak reactivity. The fourth patient, who had no evidence of additional infections, had a normal T4 value and T4/T8 ratio, but was anergic on skin testing. All the men were serologically negative for human immunodeficiency virus antibodies. One of the immunosuppressed patients developed squamous cell carcinoma of the tongue, which, along with his bowenoid papulosis, contained human papillomavirus 16 DNA. We suggest that patients with persistent bowenoid papulosis be investigated for altered immune status and followed up as potential candidates for the development of epithelial malignant neoplasms.

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“…Case report hybridization studies [3]. There are rare reports of extragenital BP with or without concomitant genital involve-A 37-year-old uncircumcised white man presented with a 3 month history of a painless penile lesion that was ment [3].…”

mentioning

confidence: 99%

“…There are rare reports of extragenital BP with or without concomitant genital involve-A 37-year-old uncircumcised white man presented with a 3 month history of a painless penile lesion that was ment [3]. BP may be confused with carcinoma in situ (CIS) of the penis; these two entities are generally believed not associated with any bleeding or discharge.…”

mentioning

confidence: 99%