Bowen's Disease With Metastases

Kuznitzky, Erich

doi:10.1001/archderm.1938.01480140031002

Cited by 11 publications

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

Treatment of Bowen's disease with topical dinitrochlorobenzene and 5-fluorouracil

Raaf¹,

Krown²,

Pinsky³

et al. 1976

Cancer

View full text Add to dashboard Cite

's disease" is a clinical and histologic diagnosis describing the lesions (single or multiple) of cutaneous in situ squamous cell carcinoma. T h e case of a 54-year.old man with 60 such intra-epidermal carcinomas, and a history of arsenic ingestion, is presented. T h e patient was sensitized to dinitrochlorobenzene (DXCB), and his lesions were treated with a topical DNCB preparation. All lesions disappeared completely (demonstrated by biopsy of several sites) except for a large (12 x 7 cm) tumor o n the flank which partially resolved.Total re6ession of this lesion was achieved by adding topical 5-fluorouracil (5-FU) therapy. This case demonstrates that the inflammatory reaction induced by DNCE (as evidenced by erythema a n d by a dense inflammatory cell infiltrate i n biopsied areas of treated lesions) can lead to regression of extensive in situ epidermoid carcinoma, and that combined therapy with DNCB and 5-FU can be more effective than DNCB alone. Both agents in appropriate concentrations led to selective destruction of neoplastic tissue with no effect on adjacent normal skin. No systemic toxicity was observed.

show abstract