Bovine papillomavirus 24: a novel member of the genus Xipapillomavirus detected in the Amazon region

Daudt, Cíntia; Silva, Flavio R. C. da; Cibulski, Samuel Paulo; Streck, André Felipe; Laurie, Rebecca E.; Munday, John S.; Canal, Cláudio Wageck

doi:10.1007/s00705-018-4092-3

Cited by 11 publications

(7 citation statements)

References 19 publications

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“…Until 2016, only 15 BPV types were fully sequenced and characterized given that conventional PCR using degenerate primer pairs selectively amplifies a virus population with high affinity to these primers and fails to detect phylogenetically distant PVs [ 23 ]. However, since the application of the RCA-HTS approach, a significant number of new BPV types have been described as well as coinfections in the same papilloma lesion [ 23 , 35 , 36 ]. This strategy applied herein identified viruses that included known papillomaviruses as well as putative and novel PV types that differ from those previously reported.…”

Section: Discussionmentioning

confidence: 99%

The genetic diversity of “papillomavirome” in bovine teat papilloma lesions

et al. 2021

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Background Papillomaviruses are small nonenveloped, circular double-stranded DNA viruses that belong to the Papillomaviridae family. To date, 29 Bos taurus papillomavirus (BPV) types have been described. Studies involving mixed BPV infections have rarely been reported in contrast to human papillomavirus (HPV), which is commonly described in numerous studies showing coinfections. Moreover, previous studies had shown that HPV coinfections increase the risk of carcinogenesis. In the present study, we used rolling-circle amplification followed by a high-throughput sequencing (RCA-HTS) approach in 23 teat papillomas from southern Brazil. Results Eleven well-characterized BPV types and 14 putative new BPV types were genetically characterized into the Xi, Epsilon and Dyoxipapillomavirus genera according to phylogenetic analysis of the L1 gene, which expands the previous 29 BPV types to 43. Moreover, BPV coinfections were detected in the majority (56.3%) of the papilloma lesions analyzed, suggesting a genetic diverse “papillomavirome” in bovine teat warts. Conclusions The data generated in this study support the possibility that a wide range of BPV is probably underdetected by conventional molecular detection tools, and that BPV coinfections are underestimated and probably genetic diverse. Additionally, 14 new BPV types were characterized, increasing the knowledge regarding BPV genetic diversity.

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Section: Discussionmentioning

confidence: 99%

The genetic diversity of “papillomavirome” in bovine teat papilloma lesions

et al. 2021

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“…ChPV2 clusters within the Beta-XiPV crown group, being confidently basal to XiPV1 . XiPV1 have been isolated from papillomas of the upper alimentary canal [ 42 ] and cutaneous papillomas of cattle from Great Britain [ 43 ] cutaneous warts of cattle from Japan and squamous papilloma lesions on cattle teats from Japan [ 44 , 45 ] as well as cutaneaous papillomatous lesion of cows in Brazil [ 46 , 47 ]. Apart from a distinct geographical occurrence and different host species, ChPV2 shares its cutaneous localization and teat involvement with the closely related XiPV1, further supporting its phylogenetic position.…”

Section: Discussionmentioning

confidence: 99%

Genomic and phylogenetic characterization of ChPV2, a novel goat PV closely related to the Xi-PV1 species infecting bovines

Willemsen

Boom

Dietz

et al. 2020

Virol J

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Background Papillomaviruses (PVs) infecting artiodactyls are very diverse, and only second in number to PVs infecting primates. PVs associated to lesions in economically important ruminant species have been isolated from cattle and sheep. Methods Potential PV DNA from teat lesions of a Damascus goat was isolated, cloned and sequenced. The PV genome was analyzed using bioinformatics approaches to detect open reading frames and to predict potential features of encoded proteins as well as putative regulatory elements. Sequence comparison and phylogenetic analyses using the concatenated E1E2L2L1 nucleotide and amino acid alignments was used to reveal the relationship of the new PV to the known PV diversity and its closest relevants. Results We isolated and characterized the full-genome of novel Capra hircus papillomavirus. We identified the E6, E7, E1, E2, L2, L1 open reading frames with protein coding potential and putative active elements in the ChPV2 proteins and putative regulatory genome elements. Sequence similarities of L1 and phylogenetic analyses using concatenated E1E2L2L1 nucleotide and amino acid alignments suggest the classification as a new PV type designated ChPV2 with a phylogenetic position within the XiPV genus, basal to the XiPV1 species. ChPV2 is not closely related to ChPV1, the other known goat PV isolated from healthy skin, although both of them belong confidently into a clade composed of PVs infecting cervids and bovids. Interestingly, ChPV2 contains an E6 open reading frame whereas all closely related PVs do not Conclusion ChPV2 is a novel goat PV closely related to the Xi-PV1 species infecting bovines. Phylogenetic relationships and genome architecture of ChPV2 and closely related PV types suggest at least two independent E6 losses within the XiPV clade.

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“…So far, at least 27 genotypes of BPVs (BPV1-27) have been identified and subsequently classified into the following genera: Deltapapillomavirus genus (BPV1, BPV2, BPV13, and BPV14), Xipapillomavirus genus (BPV3, BPV4, BPV6, BPV9, BPV10, BPV11, BPV12, BPV15, BPV17, and BPV20), Epsilonpapillomavirus genus (BPV5 and BPV8), Dyokappapapillomavirus genus (BPV16, BPV18, and BPV22), Dyoxipapillomavirus (BPV7) and unclassified genera (BPV19, BPV21, and BPV27) [ 8 11 12 13 14 15 16 17 ]. Furthermore, some unclassified papillomaviruses have been subsequently reported [ 13 15 18 19 ]. Recently, a novel type, designated as BPV28, from Japan was identified and characterized [ 17 ] and classified in the Xipapillomavirus genus.…”

Section: Introductionmentioning

confidence: 99%

Molecular detection and genetic diversity of bovine papillomavirus in dairy cows in Xinjiang, China

et al. 2021

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Background Bovine papillomatosis is a type of proliferative tumor disease of skin and mucosae caused by bovine papillomavirus (BPV). As a transboundary and emerging disease in cattle, it poses a potential threat to the dairy industry. Objectives The aim of this study is to detect and clarify the genetic diversity of BPV circulating in dairy cows in Xinjiang, China. Methods 122 papilloma skin lesions from 8 intensive dairy farms located in different regions of Xinjiang, China were detected by polymerase chain reaction. The genetic evolution relationships of various types of BPVs were analyzed by examining this phylogenetic tree. Results Ten genotypes of BPV (BPV1, BPV2, BPV3, BPV6, BPV7, BPV8, BPV10, BPV11, BPV13, and BPV14) were detected and identified in dairy cows. These were the first reported detections of BPV13 and BPV14 in Xinjiang, Mixed infections were detected, and there were geographical differences in the distribution of the BPV genotypes. Notably, the BPV infection rate among young cattle (< 1-year-old) developed from the same supply of frozen sperm was higher than that of the other young cows naturally raised under the same environmental conditions. Conclusions Genotyping based on the L1 gene of BPV showed that BPVs circulating in Xinjiang China displayed substantial genetic diversity. This study provided valuable data at the molecular epidemiology level, which is conducive to developing deep insights into the genetic diversity and pathogenic characteristics of BPVs in dairy cows.

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Bovine papillomavirus 24: a novel member of the genus Xipapillomavirus detected in the Amazon region

Cited by 11 publications

References 19 publications

The genetic diversity of “papillomavirome” in bovine teat papilloma lesions

The genetic diversity of “papillomavirome” in bovine teat papilloma lesions

Genomic and phylogenetic characterization of ChPV2, a novel goat PV closely related to the Xi-PV1 species infecting bovines

Molecular detection and genetic diversity of bovine papillomavirus in dairy cows in Xinjiang, China

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