Botulinum toxin type A versus 5-Fluorouracil in treatment of keloid

Ismail, Sahar A.; Mohammed, Noorhan H K; Sotohy, Muhammad; Abou-Taleb, Doaa A E

doi:10.1007/s00403-020-02132-8

Cited by 14 publications

(12 citation statements)

References 20 publications

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“…The use of BTX-A in treatment of keloids has been an issue of dispute. The results of the current study come in agreement with several previous reports 8, [16][17][18][19][20][21] that documented the efficacy of BTX-A in the management of keloids.…”

Section: Discussionsupporting

confidence: 93%

“…In addition, Sabry et al, 18 observed that intralesional injection of BTX‐A of keloids was more therapeutically effective than fractional CO 2 laser followed by topical application of BTX‐A. Furthermore, Ismail et al, 19 reported that intralesional injection of BTX‐A was found to be more effective than 5‐fluorouracil in the treatment of keloids even in big sized lesions with fewer adverse effects.…”

Section: Discussionmentioning

confidence: 99%

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Botulinum toxin and platelet rich plasma as innovative therapeutic modalities for keloids

Neinaa

Elsayed²,

Mohamed

et al. 2021

Dermatologic Therapy

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Keloids characterize a definitely challenging type of cutaneous scars for which a diversity of therapeutic modalities has been suggested. The aim of this work was to compare the therapeutic efficacy of intralesional injection of botulinum toxin type‐A (BTX‐A), platelet rich plasma (PRP), and triamcinolone acetonide (TAC) in keloids. A total of 60 keloids patients were enrolled and divided randomly into three equal groups. Group I treated by intralesional BTX‐A injection, group II treated by intralesional PRP injection, and group III treated by intralesional TAC injection. Clinical assessment was done by Vancouver Scar Scale (VSS), Verbal Rating Scale (VRS), and dermoscopic examination. Additionally, histopathology and immunohistochemistry of connective tissue growth factor (CTGF) expression were evaluated. The results of this study revealed significant improvement of both VSS and VRS in response to all treatment modalities. There was significant improvement of VSS in BTX‐A and PRP groups more than TAC group. However, no significant difference observed between BTX‐A and PRP groups. Immunohistochemical examination showed significant decrease of CTGF expression after treatment in BTX‐A and PRP groups more than TAC group. In conclusion, both BTX‐A and PRP could yield a chance for cosmetically better outcomes in keloids treatment than conventional TAC injection.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Botulinum toxin and platelet rich plasma as innovative therapeutic modalities for keloids

Neinaa

Elsayed²,

Mohamed

et al. 2021

Dermatologic Therapy

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“…Therefore, the degree of changes in serum MDA and SOD levels will decrease more significantly after IAH is relieved [ 12 ].…”

Section: Bont-a Injection Improves Iah In Rats Undergoing Abdominal A...mentioning

confidence: 99%

Botulinum Toxin Type A Injection Improves the Intraperitoneal High Pressure in Rats Treated with Abdominal Wall Plasty

Zhang

Shen

Yang

et al. 2022

Computational Intelligence and Neuroscience

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The aim of the study is mainly to study the subject of BoNT-A injection to improve IAH in rats undergoing abdominal angioplasty. The study problem in surgery, especially in ICU, burn, and trauma centers, intra-abdominal hypertension (IAH), and abdominal compartment syndrome (ACS) are common complications. At present, there are various treatments for IAH. The intramuscular injection of Botulinum toxin type A (BoNT-A) into the abdominal wall has received a lot of attention. Based on this, this study proposes a method for measuring abdominal pressure, applies BoNT-A to reduce abdominal pressure in the IAH state of abdominal wall angioplasty, and explores a way to increase the compliance of the abdominal wall under the premise of maintaining the sealing of the abdominal cavity, so as to realize the expansion of the abdominal cavity. A method is achieved to reduce intra-abdominal pressure and eliminate or alleviate ACS. The results of the experiment showed that when the rats in the control group were injected with the same amount of normal saline as the rats in the experimental group, the IAP was significantly higher than that in the experimental group ( P < 0.05 ). This shows that BoNT-A increases the compliance of the abdominal wall while maintaining the closure of the abdominal cavity, thereby increasing the volume of the abdominal cavity and alleviating the state of IAH in rats.

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“…After removing duplicates, 951 studies remained, of which 915 were subsequently excluded by screening the titles and abstracts. Thirty-six studies went through a full-text check, and 21 failed to pass the inspection for the following reasons: treating instead of preventing pathological scars, [11][12][13][14][15][16][17][18][19][20][21] lack of raw data, 22,23 other article types, 6,15,24 original RCT information for included articles, [25][26][27] and unfinished RCTs. 28,29 Finally, 16 RCTs with 671 cases (510 patients) met the eligibility criteria for meta-analysis (Figure 1).…”

Section: Search Resultsmentioning

confidence: 99%

Efficacy and safety of botulinum toxin type A for postoperative scar prevention and wound healing improvement: A systematic review and meta‐analysis

Huang

2021

J of Cosmetic Dermatology

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Postoperative wound healing is permanently of great concern to both surgeons and patients because pathological scars, including hypertrophic scars and keloids, profoundly affect an individual's physical and psychological well-being by causing pruritus, ulceration, pain, and contractures. Normal scar formation is an overlapping and orderly process involving hemostasis, inflammation, proliferation, and remodeling phases. 1 Although the pathogenesis of abnormal scar formation remains obscure, it is believed to be attributed to an

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Botulinum toxin type A versus 5-Fluorouracil in treatment of keloid

Cited by 14 publications

References 20 publications

Botulinum toxin and platelet rich plasma as innovative therapeutic modalities for keloids

Botulinum toxin and platelet rich plasma as innovative therapeutic modalities for keloids

Botulinum Toxin Type A Injection Improves the Intraperitoneal High Pressure in Rats Treated with Abdominal Wall Plasty

Efficacy and safety of botulinum toxin type A for postoperative scar prevention and wound healing improvement: A systematic review and meta‐analysis

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