2015
DOI: 10.1590/s0102-865020150090000009
|View full text |Cite
|
Sign up to set email alerts
|

Botulinum toxin type A on cutaneous flap viability in diabetic and tobacco-exposed rats

Abstract: PURPOSE:To investigate the effect of Botulinum toxin A (BoNTA) on skin flap viability in healthy, tobacco-exposed and diabetic rats. METHODS:Ninety male Wistar rats (250-300g) were randomly divided into six groups: control+saline (C1), control+BoNTA (C2), tobacco-exposed+saline (T1), tobacco-exposed+BoNTA (T2) diabetes+saline (D1) and diabetes+BoNTA (D2). A dorsal cutaneous flap (3×10cm) was performed. Survival area and total area of the flaps were measured. Lumen diameter, external arterial diameter and lumen… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
15
1

Year Published

2016
2016
2022
2022

Publication Types

Select...
8

Relationship

2
6

Authors

Journals

citations
Cited by 18 publications
(16 citation statements)
references
References 27 publications
(44 reference statements)
0
15
1
Order By: Relevance
“…Moreover, there was no difference in terms of flap viability between health (no exposure) and smoke-exposure animals in this previous study 9 . We hypothesized that the 3x10cm flap would cause a very severe vascular insufficiency resulting in necrosis, and that no additional deleterious environmental factor (tobacco-exposure) would increase necrosis.…”
Section: Resultscontrasting
confidence: 52%
See 2 more Smart Citations
“…Moreover, there was no difference in terms of flap viability between health (no exposure) and smoke-exposure animals in this previous study 9 . We hypothesized that the 3x10cm flap would cause a very severe vascular insufficiency resulting in necrosis, and that no additional deleterious environmental factor (tobacco-exposure) would increase necrosis.…”
Section: Resultscontrasting
confidence: 52%
“…Although BontA showed a difference in health and diabetic animals, there was no BontA effect in the flap viability for the tobacco-exposed group 9 . This hypothesis was based on other studies 10,11 .…”
Section: Introductionmentioning
confidence: 76%
See 1 more Smart Citation
“…We adopted this model to mimic a moderate smoker patient. According to our previous study this model induced a carboxyhemoglobin level similar to a moderate smoker 17 , 18 . Moreover, we exposed the animal for two-months to cause a tobacco endothelial dysfunction 11 , 17 .…”
Section: Discussionmentioning
confidence: 99%
“…In one study, BoNT/A was used to prevent unfavourable effects of cigarette smoke in Wistar albino rats . In another study, it increased skin‐flap viability in diabetic rats, which was associated with an increase of lumen diameter, external arterial diameter and lumen/wall thickness ratio . At the molecular level, BoNT/A affected the expression of vascular endothelial growth factor, platelet endothelial cell adhesion molecule 1, CD31, CD34, interleukin (IL)‐1 and tumour necrosis factor‐α in cutaneous flaps .…”
Section: Experimental Studies Of Cutaneous Effects Of Botulinum Neuromentioning
confidence: 99%