Botulinum Toxin to Improve Results in Cleft Lip Repair

Abstract

Therapeutic, II.

The Safety and efficacy of botulinum toxin type A injection for postoperative scar prevention: A systematic review and meta‐analysis

“…But the results of some experiments are inconsistent. In the 2 studies of Chang et al and Hu et al, there were significant differences in VAS score and scar width between the two groups, but no significant differences in VSS score. According to the authors, this may be because this scale is applicable to the evaluation of burn scars, but not highly sensitive to nonburn scars.…”

“…A total of 10 studies were included in the comparison, but two studies measured the data from two points, so there were 12 data in total (Figure ). The standardized mean difference (SMD) was chosen because of the large gap between the research results (0.32 ~ 3.25 mm).…”

“…A total of 9 studies were included in the comparison (Figure ) . The heterogeneity test suggested that there was heterogeneity between studies ( χ 2 = 139.16, P ＜ .00001, I 2 = 94%＞50%), so the random effect model was adopted for the combination, WMD = −1.82[95%CI: (−2.54,‐1.10), P ＜ .00001]; The results suggested that the VSS scores were significantly different between the two groups, and the VSS score was lower in the BTXA group than in the control group.…”

“…Besides transient pain, pruritus, and mild headache at the injection point, there were 2 cases of ptosis, 1 case of philtrum fixation wound, 1 case of asymmetrical smile, 1 case of asymmetric oral commissure, 1 case of asymmetric eyebrow, 1 case of abscess, and 1 case of ischemia. The remaining 5 studies reported no adverse events, and 3 studies did not report …”

“…Five studies failed to state the dose of BTXA . Two studies calculated the dose based on body weight (1‐2 U/kg) . Others mainly determined the injection dose based on the length of the scar (1.5‐10 U/cm) or the number of injection point (0.5‐5 U/site), lacking of comparability.…”