Botulinum toxin for the treatment of strabismus

Abstract

The majority of published literature on the use of botulinum toxin in the treatment of strabismus consists of retrospective studies, cohort studies or case reviews. Although these provide useful descriptive information, clarification is required as to the effective use of botulinum toxin as an independent treatment modality. Four RCTs on the therapeutic use of botulinum toxin in strabismus have shown varying responses ranging from a lack of evidence for prophylactic effect of botulinum toxin in acute sixth nerve palsy, to poor response in patients with horizontal strabismus without binocular vision, to no difference in response in patients that required retreatment for acquired esotropia or infantile esotropia. It was not possible to establish dose effect information. Complication rates for use of Botox™ or Dysport™ ranged from 24% to 55.54%.

Correlation of Botulinum Toxin Dose with Neurophysiological Parameters of Efficacy and Safety in the Glabellar Muscles: A Double-blind, Placebo-controlled, Randomized Study

“…Adverse effects of BoNT-A after injection in the glabellar area include a risk of blepharoptosis, occurring in 2.5-9.5% of cases (20,(23)(24)(25). We did not observe blepharoptosis and, with the exception of one case with seborrhoeic eczema, no adverse events were reported.…”

Correlation of Botulinum Toxin Dose with Neurophysiological Parameters of Efficacy and Safety in the Glabellar Muscles: A Double-blind, Placebo-controlled, Randomized Study

“…Adverse effects of BoNT-A after injection in the glabellar area include a risk of blepharoptosis, occurring in 2.5-9.5% of cases (20,(23)(24)(25). We did not observe blepharoptosis and, with the exception of one case with seborrhoeic eczema, no adverse events were reported.…”

The side effect of Botulinum toxin A injection for position of the eyelid

“…The secondary side effects such as above all vertical deviation, as well as ptosis etc. [8] are decisively in favour of a negative standpoint, 24 % in the case of Dysport R and 55 % in the case of Botox R [7]. Extensive studies about blepharospasm demonstrated a fundamentally positive therapeutic effect of a derivate of Botulotoxin A in the cases of this disorder, unlike previously used avulsion of the facial nerve [9,10].…”

Community Knowledge, Attitude, and Practices Related to Strabismus and Strabismus Treatment and Surgery in Al-Jouf Region, Saudi Arabia

“…It normally takes two to three months for the altered ocular alignment to resolve [ 17 ]. This strategy is thought to be challenging to use in youngsters since it necessitates anesthesia and can cause difficulties in case the toxin leaks into the muscle that raises the eyelid, the levator palpebrae superioris, causing a droopy upper lid (ptosis) [ 18 , 19 ]. In our study, 60.3% of participants reported both eyeglasses and surgery as treatment of strabismus, 42.9% reported glasses and contact lenses, and 23.5% reported eyepatch and surgery, while 7.6% reported Botox injection.…”

Correlation of Botulinum Toxin Dose with Neurophysiological Parameters of Efficacy and Safety in the Glabellar Muscles: A Double-blind, Placebo-controlled, Randomized Study

“…Adverse effects of BoNT-A after injection in the glabellar area include a risk of blepharoptosis, occurring in 2.5-9.5% of cases (20,(23)(24)(25). We did not observe blepharoptosis and, with the exception of one case with seborrhoeic eczema, no adverse events were reported.…”

The side effect of Botulinum toxin A injection for position of the eyelid

“…The secondary side effects such as above all vertical deviation, as well as ptosis etc. [8] are decisively in favour of a negative standpoint, 24 % in the case of Dysport R and 55 % in the case of Botox R [7]. Extensive studies about blepharospasm demonstrated a fundamentally positive therapeutic effect of a derivate of Botulotoxin A in the cases of this disorder, unlike previously used avulsion of the facial nerve [9,10].…”

Community Knowledge, Attitude, and Practices Related to Strabismus and Strabismus Treatment and Surgery in Al-Jouf Region, Saudi Arabia

“…It normally takes two to three months for the altered ocular alignment to resolve [ 17 ]. This strategy is thought to be challenging to use in youngsters since it necessitates anesthesia and can cause difficulties in case the toxin leaks into the muscle that raises the eyelid, the levator palpebrae superioris, causing a droopy upper lid (ptosis) [ 18 , 19 ]. In our study, 60.3% of participants reported both eyeglasses and surgery as treatment of strabismus, 42.9% reported glasses and contact lenses, and 23.5% reported eyepatch and surgery, while 7.6% reported Botox injection.…”

Correlation of Botulinum Toxin Dose with Neurophysiological Parameters of Efficacy and Safety in the Glabellar Muscles: A Double-blind, Placebo-controlled, Randomized Study

“…Adverse effects of BoNT-A after injection in the glabellar area include a risk of blepharoptosis, occurring in 2.5-9.5% of cases (20,(23)(24)(25). We did not observe blepharoptosis and, with the exception of one case with seborrhoeic eczema, no adverse events were reported.…”

The side effect of Botulinum toxin A injection for position of the eyelid

“…The secondary side effects such as above all vertical deviation, as well as ptosis etc. [8] are decisively in favour of a negative standpoint, 24 % in the case of Dysport R and 55 % in the case of Botox R [7]. Extensive studies about blepharospasm demonstrated a fundamentally positive therapeutic effect of a derivate of Botulotoxin A in the cases of this disorder, unlike previously used avulsion of the facial nerve [9,10].…”

Community Knowledge, Attitude, and Practices Related to Strabismus and Strabismus Treatment and Surgery in Al-Jouf Region, Saudi Arabia

“…It normally takes two to three months for the altered ocular alignment to resolve [ 17 ]. This strategy is thought to be challenging to use in youngsters since it necessitates anesthesia and can cause difficulties in case the toxin leaks into the muscle that raises the eyelid, the levator palpebrae superioris, causing a droopy upper lid (ptosis) [ 18 , 19 ]. In our study, 60.3% of participants reported both eyeglasses and surgery as treatment of strabismus, 42.9% reported glasses and contact lenses, and 23.5% reported eyepatch and surgery, while 7.6% reported Botox injection.…”