Boosting the Sonodynamic Cancer Therapy Performance of 2D Layered Double Hydroxide Nanosheet‐Based Sonosensitizers Via Crystalline‐to‐Amorphous Phase Transformation

Hu, Tingting; Shen, Weicheng; Meng, Fanqi; Yang, Shuqing; Yu, Shilong; Li, Hai; Zhang, Qinghua; Gu, Lin; Tan, Chaoliang; Liang, Ruizheng

doi:10.1002/adma.202209692

Cited by 50 publications

(54 citation statements)

References 60 publications

(80 reference statements)

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“…By contrast, SDT and CDT that does not need light activation are comparatively promising for treating bone tumors and worthy of further study. For example, Hu et al [280] realized the phase transition of CoW-LDH and NiW-LDH nanosheets from polycrystalline to amorphous by simple acid etching treatment, as a high-efficiency sonosensitizer for SDT. Due to the defect generation induced by phase transformation and electronic structure changes, amorphous CoW-LDH nanosheets appear to have higher ROS-generating ability under ultrasound irradiation and achieve effective tumor-killing effects.…”

Section: Perspective and Conclusionmentioning

confidence: 99%

Layered Double Hydroxides: A Novel Promising 2D Nanomaterial for Bone Diseases Treatment

Bian

Cai

et al. 2023

Advanced Science

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Bone diseases including bone defects, bone infections, osteoarthritis, and bone tumors seriously affect life quality of the patient and bring serious economic burdens to social health management, for which the current clinical treatments bear dissatisfactory therapeutic effects. Biomaterial‐based strategies have been widely applied in the treatment of orthopedic diseases but are still plagued by deficient bioreactivity. With the development of nanotechnology, layered double hydroxides (LDHs) with adjustable metal ion composition and alterable interlayer structure possessing charming physicochemical characteristics, versatile bioactive properties, and excellent drug loading and delivery capabilities arise widespread attention and have achieved considerable achievements for bone disease treatment in the last decade. However, to the authors' best knowledge, no review has comprehensively summarized the advances of LDHs in treating bone disease so far. Herein, the advantages of LDHs for orthopedic disorders treatment are outlined and the corresponding state‐of‐the‐art achievements are summarized for the first time. The potential of LDHs‐based nanocomposites for extended therapeutics for bone diseases is highlighted and perspectives for LDHs‐based scaffold design are proposed for facilitated clinical translation.

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Section: Perspective and Conclusionmentioning

confidence: 99%

Layered Double Hydroxides: A Novel Promising 2D Nanomaterial for Bone Diseases Treatment

Bian

Cai

et al. 2023

Advanced Science

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“…However, there has been a report on CoW-LDH, which can function as high-efficiency inorganic sonosensitizers for sonodynamic cancer therapy in recent years. [104] As shown in Figure 16A(a), the a-CoW-LDH nanosheets were prepared via CoW-LDH under US irradiation. Its SDT performance is ≈5 times better than LDHs, which is attributed to the crystalline-to-amorphous phase transformation-induced bandgap narrowing, electronic structure changing, and defect generation.…”

Section: Sonodynamic Therapymentioning

confidence: 99%

Section: Sonodynamic Therapymentioning

confidence: 99%

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Microenvironment Restruction of Emerging 2D Materials and their Roles in Therapeutic and Diagnostic Nano‐Bio‐Platforms

et al. 2023

Advanced Science

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Engineering advanced therapeutic and diagnostic nano‐bio‐platforms (NBPFs) have emerged as rapidly‐developed pathways against a wide range of challenges in antitumor, antipathogen, tissue regeneration, bioimaging, and biosensing applications. Emerged 2D materials have attracted extensive scientific interest as fundamental building blocks or nanostructures among material scientists, chemists, biologists, and doctors due to their advantageous physicochemical and biological properties. This timely review provides a comprehensive summary of creating advanced NBPFs via emerging 2D materials (2D‐NBPFs) with unique insights into the corresponding molecularly restructured microenvironments and biofunctionalities. First, it is focused on an up‐to‐date overview of the synthetic strategies for designing 2D‐NBPFs with a cross‐comparison of their advantages and disadvantages. After that, the recent key achievements are summarized in tuning the biofunctionalities of 2D‐NBPFs via molecularly programmed microenvironments, including physiological stability, biocompatibility, bio‐adhesiveness, specific binding to pathogens, broad‐spectrum pathogen inhibitors, stimuli‐responsive systems, and enzyme‐mimetics. Moreover, the representative therapeutic and diagnostic applications of 2D‐NBPFs are also discussed with detailed disclosure of their critical design principles and parameters. Finally, current challenges and future research directions are also discussed. Overall, this review will provide cutting‐edge and multidisciplinary guidance for accelerating future developments and therapeutic/diagnostic applications of 2D‐NBPFs.

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“…For example, Liang group dispersed the as-prepared CoW-2D layered double hydroxide (CoW-LDH) nanosheets in phosphate buffer solution (pH = 4) for different times (0.5, 2, 4, 6, 12, 24 h) to obtain amorphous CoW-LDH (a-CoW-LDH). [67] They found that acid etching produced abundant oxygen vacancy defects on CoW-LDH nanosheets and caused W 6+ to be partially reduced to W 5+ . These structural changes lead to the phase transition of CoW-LDH nanocrystals from crystal to an amorphous phase.…”

Section: Introduction Of Defects Into Presynthesized Nanomaterialsmentioning

confidence: 99%

Defect Engineering in Biomedical Sciences

et al. 2023

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With the promotion of nanochemistry research, large numbers of nanomaterials have been applied in vivo to produce desirable cytotoxic substances in response to endogenous or exogenous stimuli for achieving disease‐specific therapy. However, the performance of nanomaterials is a critical issue that is difficult to improve and optimize under biological conditions. Defect‐engineered nanoparticles have become the most researched hot materials in biomedical applications recently due to their excellent physicochemical properties, such as optical properties and redox reaction capabilities. Importantly, the properties of nanomaterials can be easily adjusted by regulating the type and concentration of defects in the nanoparticles without requiring other complex designs. Therefore, this tutorial review focuses on biomedical defect engineering and briefly discusses defect classification, introduction strategies, and characterization techniques. Several representative defective nanomaterials are especially discussed in order to reveal the relationship between defects and properties. A series of disease treatment strategies based on defective engineered nanomaterials are summarized. By summarizing the design and application of defective engineered nanomaterials, a simple but effective methodology is provided for researchers to design and improve the therapeutic effects of nanomaterial‐based therapeutic platforms from a materials science perspective.

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Boosting the Sonodynamic Cancer Therapy Performance of 2D Layered Double Hydroxide Nanosheet‐Based Sonosensitizers Via Crystalline‐to‐Amorphous Phase Transformation

Abstract: Figure 1. Schematic illustration of the preparation of a-CoW-LDH-PEG nanosheets and their application in SDT.

Cited by 50 publications

References 60 publications

Layered Double Hydroxides: A Novel Promising 2D Nanomaterial for Bone Diseases Treatment

Layered Double Hydroxides: A Novel Promising 2D Nanomaterial for Bone Diseases Treatment

Microenvironment Restruction of Emerging 2D Materials and their Roles in Therapeutic and Diagnostic Nano‐Bio‐Platforms

Defect Engineering in Biomedical Sciences

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