Boosting the catalytic performance of manganese (III)‐porphyrin complex MnTSPP for facile one‐pot green synthesis of 1,4‐dihydropyridine derivatives under mild conditions

Abstract

In this study, the metal complex (5,10,15,20‐tetrakis‐(4‐sulfonatophenyl)‐porphyrin manganese (III) chloride; denoted as MnTSPP) represents a promising efficient and reusable heterogeneous solid catalyst for facile and highly efficient one‐pot synthesis of 1,4 dihydropyridine derivatives via three‐component condensation reaction of aromatic aldehyde, ethyl acetoacetate, and ammonium acetate under green and mild reaction conditions. The simple operation, short reaction time (15 min), and the high efficiency (99%) are the special advantage of this protocol. Furthermore, the green aspects of this synthetic protocol were more studied by examination of the reusability of MnTSPP for four consecutive cycles without a significant loss of catalytic activity. Remarkably, the new synthesis presented advantages in terms of safety, commercially available catalyst, simplicity, stability, mild conditions, short reaction time, and excellent yields, using a mixture of H2O and C2H5OH environmental‐friendly solvent, operationally facile, wide tolerance of starting materials, and excellent recoverable of the catalyst.

RETRACTED: Synthesis of efficient cobalt–metal organic framework as reusable nanocatalyst in the synthesis of new 1,4-dihydropyridine derivatives with antioxidant activity

“…The most important method for the synthesis of 1,4-dihydropyridine was the application of dimedone, acetoacetate, aldehyde derivatives, and ammonium acetate using various catalysts ( Calvino-Casilda and Martín-Aranda, 2020 ; Ali El-Remaily et al, 2021 ; Maleki et al, 2021 ).…”

A CMC-g-poly(AA-co-AMPS)/Fe3O4 hydrogel nanocomposite as a novel biopolymer-based catalyst in the synthesis of 1,4-dihydropyridines

“…Moreover, high yields of products were found for heteroaryl aldehydes (Table 2, entries 17–20). 28,54–60…”

Sequential Assembly and Stabilization of Cu6S6 Octahedral Clusters in NaCl-, NiAs-, and CdI2-Related Structures and Their Utility toward Thermochromism and Multicomponent Hantzsch Reaction

“…A possible mechanism for the catalytic reaction was arrived based on earlier studies (Figure 10). 72 To test the catalytic nature of this reaction, we have carried out a hot-filtration study. The hot-filtration study, employing compound I, indicated that the reaction did not proceed in the absence of the catalyst�though a small increase in the product was observed over the course of the reaction time of 60 min (Figure S25).…”