Boosting bone cell growth using nanofibrous carboxymethylated cellulose and chitosan on titanium dioxide nanotube array with dual surface charges as a novel multifunctional bioimplant surface

Rahnamaee, Seyed Yahya; Dehnavi, Seyed Mohsen; Bagheri, Reza; Barjasteh, Mahdi; Golizadeh, Mortaza; Zamani, Hedyeh; Karimi, Afzal

doi:10.1016/j.ijbiomac.2022.12.159

Cited by 15 publications

(3 citation statements)

References 58 publications

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“…In addition, chitosan combines with polyanions such as gelatin [72,73], hyaluronic acid [74], and sodium alginate [75,76] to form a polyelectrolyte complex, promoting the surface functionalization of titanium. Modified carboxymethyl chitosan nanofibers, as a novel implant coating on titania nanotube arrays, inhibit bacterial colony formation and increase osteoblast cell survival [77] (Figure 4). Similarly, carboxymethyl chitosan loaded with silver nanoparticles enhances the antibacterial properties of the titanium alloy [78].…”

Section: Chitosan-based Hydrogel Coatingmentioning

confidence: 99%

Progress in Surface Modification of Titanium Implants by Hydrogel Coatings

Chen

Feng

Xia

et al. 2023

Gels

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Although titanium and titanium alloys have become the preferred materials for various medical implants, surface modification technology still needs to be strengthened in order to adapt to the complex physiological environment of the human body. Compared with physical or chemical modification methods, biochemical modification, such as the introduction of functional hydrogel coating on implants, can fix biomolecules such as proteins, peptides, growth factors, polysaccharides, or nucleotides on the surface of the implants, so that they can directly participate in biological processes; regulate cell adhesion, proliferation, migration, and differentiation; and improve the biological activity on the surface of the implants. This review begins with a look at common substrate materials for hydrogel coatings on implant surfaces, including natural polymers such as collagen, gelatin, chitosan, and alginate, and synthetic materials such as polyvinyl alcohol, polyacrylamide, polyethylene glycol, and polyacrylic acid. Then, the common construction methods of hydrogel coating (electrochemical method, sol–gel method and layer-by-layer self-assembly method) are introduced. Finally, five aspects of the enhancement effect of hydrogel coating on the surface bioactivity of titanium and titanium alloy implants are described: osseointegration, angiogenesis, macrophage polarization, antibacterial effects, and drug delivery. In this paper, we also summarize the latest research progress and point out the future research direction. After searching, no previous relevant literature reporting this information was found.

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Section: Chitosan-based Hydrogel Coatingmentioning

confidence: 99%

Progress in Surface Modification of Titanium Implants by Hydrogel Coatings

Chen

Feng

Xia

et al. 2023

Gels

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“…Moreover, having a fully nanoporous platform, the MOFs-functionalized wound dressings can mimic the biological nanoscale structures of the extracellular matrix (ECM) 2,3,24 . Silver-based MOFs (Ag-MOFs) are one of the new kinds of MOFs, which can be made using different organic ligands.…”

Section: Introductionmentioning

confidence: 99%

Hybrid nanocomposite wound dressings by a novel nanorod vitamin-B3-Ag metal-organic framework and bacterial cellulose nanofibers

Barjasteh,

Dehnavi,

Ahmadi Seyedkhani

et al. 2024

Journal of Drug Delivery Science and Technology

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“…Silver nanoparticles (AgNPs) have long been considered for their antibacterial capacity, although their cytotoxicity has significantly hindered their progress toward clinical application [50][51][52][53][54][55]. Meanwhile, titanium dioxide nanoparticles (TiO 2 NPs) have shown antibacterial efficacy while demonstrating better cytocompatibility [56][57][58][59][60] and even promoting bone formation owing their osteoconductive properties [57,[61][62][63][64]. The particle's surface area to volume determines the binding and ion release properties, which are crucial for antimicrobial activity.…”

Section: Introductionmentioning

confidence: 99%

Titanium-Dioxide-Nanoparticle-Embedded Polyelectrolyte Multilayer as an Osteoconductive and Antimicrobial Surface Coating

Rothpan,

Chandra Teja Dadi,

McKay

et al. 2023

Materials

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Bioactive surface coatings have retained the attention of researchers and physicians due to their versatility and range of applications in orthopedics, particularly in infection prevention. Antibacterial metal nanoparticles (mNPs) are a promising therapeutic, with vast application opportunities on orthopedic implants. The current research aimed to construct a polyelectrolyte multilayer on a highly porous titanium implant using alternating thin film coatings of chitosan and alginate via the layer-by-layer (LbL) self-assembly technique, along with the incorporation of silver nanoparticles (AgNPs) or titanium dioxide nanoparticles (TiO2NPs), for antibacterial and osteoconductive activity. These mNPs were characterized for their physicochemical properties using quartz crystal microgravimetry with a dissipation system, nanoparticle tracking analysis, scanning electron microscopy, and atomic force microscopy. Their cytotoxicity and osteogenic differentiation capabilities were assessed using AlamarBlue and alkaline phosphatase (ALP) activity assays, respectively. The antibiofilm efficacy of the mNPs was tested against Staphylococcus aureus. The LbL polyelectrolyte coating was successfully applied to the porous titanium substrate. A dose-dependent relationship between nanoparticle concentration and ALP as well as antibacterial effects was observed. TiO2NP samples were also less cytotoxic than their AgNP counterparts, although similarly antimicrobial. Together, these data serve as a proof-of-concept for a novel coating approach for orthopedic implants with antimicrobial and osteoconductive properties.

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Boosting bone cell growth using nanofibrous carboxymethylated cellulose and chitosan on titanium dioxide nanotube array with dual surface charges as a novel multifunctional bioimplant surface

Cited by 15 publications

References 58 publications

Progress in Surface Modification of Titanium Implants by Hydrogel Coatings

Progress in Surface Modification of Titanium Implants by Hydrogel Coatings

Hybrid nanocomposite wound dressings by a novel nanorod vitamin-B3-Ag metal-organic framework and bacterial cellulose nanofibers

Titanium-Dioxide-Nanoparticle-Embedded Polyelectrolyte Multilayer as an Osteoconductive and Antimicrobial Surface Coating

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