Bone scaffolds from electrospun fiber mats of poly(3-hydroxybutyrate), poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and their blend

Sombatmankhong, Korakot; Sanchavanakit, Neeracha; Pavasant, Prasit; Supaphol, Pitt

doi:10.1016/j.polymer.2007.01.014

Cited by 178 publications

(108 citation statements)

References 28 publications

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“…The average angle of ~116° was measured for uncoated PHB fibers which is in close agreement with previously reported results (Sombatmankhong et al 2007). PMMA coated electrospun PHB fibers has become extremely hydrophobic with the contact angle of almost 126° due to the PMMA coverage (Fig.3b).…”

Section: Resultssupporting

confidence: 92%

Polymethacrylate coated electrospun PHB fibers: An exquisite outlook for fabrication of paper-based biosensors

Hosseini

Azari

Farahmand

et al. 2015

Biosensors and Bioelectronics

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Section: Resultssupporting

confidence: 92%

Polymethacrylate coated electrospun PHB fibers: An exquisite outlook for fabrication of paper-based biosensors

Hosseini

Azari

Farahmand

et al. 2015

Biosensors and Bioelectronics

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“…Up to date, various alternatives, such as metals, ceramics, and polymers, have been proposed to be used as scaffold materials. However, nowadays scaffolds are typically fashioned from biodegradable materials of natural origin proteins like collagen 1 and silk fibroin, 2 and polymers like chitosan, 3 starch, 4 and poly(3-hydroxybutyrate), 5 and also from synthetic polymers such as poly(lactide), 6 poly(lactide/glycolide), 7 and polycaprolactone. 8 Although synthetic polymers appear to be a good choice regarding processing, critical problems in biocompatibility, degradation products, and numerous other issues still remain to be solved.…”

mentioning

confidence: 99%

Design of Nano- and Microfiber Combined Scaffolds by Electrospinning of Collagen onto Starch-Based Fiber Meshes: A Man-Made Equivalent of Natural Extracellular Matrix

Tuzlakoğlu

Santos

Neves

et al. 2011

Tissue Engineering Part A

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Mimicking the structural organization and biologic function of natural extracellular matrix has been one of the main goals of tissue engineering. Nevertheless, the majority of scaffolding materials for bone regeneration highlights biochemical functionality in detriment of mechanical properties. In this work we present a rather innovative construct that combines in the same structure electrospun type I collagen nanofibers with starchbased microfibers. These combined structures were obtained by a two-step methodology and structurally consist in a type I collagen nano-network incorporated on a macro starch-based support. The morphology of the developed structures was assessed by several microscopy techniques and the collagenous nature of the nanonetwork was confirmed by immunohistochemistry. In addition, and especially regarding the requirements of large bone defects, we also successfully introduced the concept of layer by layer, as a way to produce thicker structures. In an attempt to recreate bone microenvironment, the design and biochemical composition of the combined structures also envisioned bone-forming cells and endothelial cells (ECs). The inclusion of a type I collagen nano-network induced a stretched morphology and improved the metabolic activity of osteoblasts. Regarding ECs, the presence of type I collagen on the combined structures provided adhesive support and obviated the need of precoating with fibronectin. It was also importantly observed that ECs on the nano-network organized into circular structures, a three-dimensional arrangement distinct from that observed for osteoblasts and resembling the microcappillary-like organizations formed during angiogenesis. By providing simultaneously physical and chemical cues for cells, the herein-proposed combined structures hold a great potential in bone regeneration as a man-made equivalent of extracellular matrix.

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“…28 Therefore, the longer stability of the ejected charged jet leads to fewer numbers of pores and thicker bridges. 29 For more, it is probable for the upper layers to overlap the pores of the layer beneath, and a greater reduction is expected in pore interconnectivity. This became crystal clear when a dramatic increase occurred when the solution was concentrated above a 6 wt % P3HB content (Fig.…”

Section: Polymer Concentrationmentioning

confidence: 99%

Experimental investigation of the governing parameters in the electrospinning of poly(3‐hydroxybutyrate) scaffolds: Structural characteristics of the pores

Tehrani

Ali

Karbasi

et al. 2010

J of Applied Polymer Sci

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We sought to determine the impact of electrospinning parameters on a trustworthy criterion that could evidently improve the maximum applicability of fibrous scaffolds for tissue regeneration. We used an image analysis technique to elucidate the web permeability index (WPI) by modeling the formation of electrospun scaffolds. Poly(3-hydroxybutyrate) (P3HB) scaffolds were fabricated according to predetermined conditions of levels in a Taguchi orthogonal design. The material parameters were the polymer concentration, conductivity, and volatility of the solution. The processing parameters were the applied voltage and nozzle-to-collector distance. With a law to monitor the WPI values when the polymer concentration or the applied voltage was increased, the pore interconnectivity was decreased. The quality of the jet instability altered the pore numbers, areas, and other structural characteristics, all of which determined the scaffold porosity and aperture interconnectivity. An initial drastic increase was observed in the WPI values because of the chain entanglement phenomenon above a 6 wt % P3HB content. Although the solution mixture significantly (p < 0.05) changed the scaffold architectural characteristics as a function of the solution viscosity and surface tension, it had a minor impact on the WPI values. The solution mixture gained the third place of significance, and the distance was approved as the least important factor.

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Bone scaffolds from electrospun fiber mats of poly(3-hydroxybutyrate), poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and their blend

Cited by 178 publications

References 28 publications

Polymethacrylate coated electrospun PHB fibers: An exquisite outlook for fabrication of paper-based biosensors

Polymethacrylate coated electrospun PHB fibers: An exquisite outlook for fabrication of paper-based biosensors

Design of Nano- and Microfiber Combined Scaffolds by Electrospinning of Collagen onto Starch-Based Fiber Meshes: A Man-Made Equivalent of Natural Extracellular Matrix

Experimental investigation of the governing parameters in the electrospinning of poly(3‐hydroxybutyrate) scaffolds: Structural characteristics of the pores

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