Bone Resection in the Excision of Epithelial Tumors of the Lacrimal Gland

Does Multimodal Treatment Improve Eye and Life Salvage in Adenoid Cystic Carcinoma of the Lacrimal Gland?

“…ACC of the lacrimal gland, considered a “treacherous neoplasm,” is characterized by a high rate of local tumor recurrence and systemic metastasis, and a dismal prognosis for survival. 1–22,28 Management of ACC of the lacrimal gland involves surgery, EBRT, and chemotherapy. Complete surgical clearance is difficult to achieve due to the infiltrative nature of the tumor, perineural invasion, soft tissue infiltration, and bone involvement.…”

“…3,17,24 Not surprisingly, orbital exenteration and radical cranio-orbital resection have not resulted in improved local tumor control or survival. 1–22,28 Logically, postoperative adjuvant EBRT may improve local tumor control and systemic chemotherapy may minimize the risk of metastasis.…”

“…Removal of the adjacent bone was attempted in recurrent tumors. 18,20 Radical surgery involving orbital bone resection was not routinely performed due to the high risk of meningitis and death. 1 Murray and colleagues proposed cranio-orbital resection for primary orbital disease.…”

“…17 Radical orbital exenteration has failed to demonstrate a benefit over conservative eye-sparing procedures in improving the outcome. 8,10,18,22 Because of these well-known limitations of surgical modalities, postoperative adjuvant EBRT was advocated to potentially reduce the risk of local tumor recurrence. 17,22 Despite surgery and EBRT, systemic prognosis of these patients remains grim, with survival of ≤50% at 5 years and 20% at 10 years.…”

Does Multimodal Treatment Improve Eye and Life Salvage in Adenoid Cystic Carcinoma of the Lacrimal Gland?

“…ACC of the lacrimal gland, considered a “treacherous neoplasm,” is characterized by a high rate of local tumor recurrence and systemic metastasis, and a dismal prognosis for survival. 1–22,28 Management of ACC of the lacrimal gland involves surgery, EBRT, and chemotherapy. Complete surgical clearance is difficult to achieve due to the infiltrative nature of the tumor, perineural invasion, soft tissue infiltration, and bone involvement.…”

“…3,17,24 Not surprisingly, orbital exenteration and radical cranio-orbital resection have not resulted in improved local tumor control or survival. 1–22,28 Logically, postoperative adjuvant EBRT may improve local tumor control and systemic chemotherapy may minimize the risk of metastasis.…”

“…Removal of the adjacent bone was attempted in recurrent tumors. 18,20 Radical surgery involving orbital bone resection was not routinely performed due to the high risk of meningitis and death. 1 Murray and colleagues proposed cranio-orbital resection for primary orbital disease.…”

“…17 Radical orbital exenteration has failed to demonstrate a benefit over conservative eye-sparing procedures in improving the outcome. 8,10,18,22 Because of these well-known limitations of surgical modalities, postoperative adjuvant EBRT was advocated to potentially reduce the risk of local tumor recurrence. 17,22 Despite surgery and EBRT, systemic prognosis of these patients remains grim, with survival of ≤50% at 5 years and 20% at 10 years.…”

Past, present, and future surgical management of malignant epithelial neoplasms of the lacrimal gland.

“…1). 4 At the time of their report this surgical procedure had been used on five patients with lacrimal gland neoplasms. Two of these five cases were adenoid cystic carcinomas.…”

Does Multimodal Treatment Improve Eye and Life Salvage in Adenoid Cystic Carcinoma of the Lacrimal Gland?

“…ACC of the lacrimal gland, considered a “treacherous neoplasm,” is characterized by a high rate of local tumor recurrence and systemic metastasis, and a dismal prognosis for survival. 1–22,28 Management of ACC of the lacrimal gland involves surgery, EBRT, and chemotherapy. Complete surgical clearance is difficult to achieve due to the infiltrative nature of the tumor, perineural invasion, soft tissue infiltration, and bone involvement.…”

“…3,17,24 Not surprisingly, orbital exenteration and radical cranio-orbital resection have not resulted in improved local tumor control or survival. 1–22,28 Logically, postoperative adjuvant EBRT may improve local tumor control and systemic chemotherapy may minimize the risk of metastasis.…”

“…Removal of the adjacent bone was attempted in recurrent tumors. 18,20 Radical surgery involving orbital bone resection was not routinely performed due to the high risk of meningitis and death. 1 Murray and colleagues proposed cranio-orbital resection for primary orbital disease.…”

“…17 Radical orbital exenteration has failed to demonstrate a benefit over conservative eye-sparing procedures in improving the outcome. 8,10,18,22 Because of these well-known limitations of surgical modalities, postoperative adjuvant EBRT was advocated to potentially reduce the risk of local tumor recurrence. 17,22 Despite surgery and EBRT, systemic prognosis of these patients remains grim, with survival of ≤50% at 5 years and 20% at 10 years.…”

Past, present, and future surgical management of malignant epithelial neoplasms of the lacrimal gland.

“…1). 4 At the time of their report this surgical procedure had been used on five patients with lacrimal gland neoplasms. Two of these five cases were adenoid cystic carcinomas.…”

Does Multimodal Treatment Improve Eye and Life Salvage in Adenoid Cystic Carcinoma of the Lacrimal Gland?

“…ACC of the lacrimal gland, considered a “treacherous neoplasm,” is characterized by a high rate of local tumor recurrence and systemic metastasis, and a dismal prognosis for survival. 1–22,28 Management of ACC of the lacrimal gland involves surgery, EBRT, and chemotherapy. Complete surgical clearance is difficult to achieve due to the infiltrative nature of the tumor, perineural invasion, soft tissue infiltration, and bone involvement.…”

“…3,17,24 Not surprisingly, orbital exenteration and radical cranio-orbital resection have not resulted in improved local tumor control or survival. 1–22,28 Logically, postoperative adjuvant EBRT may improve local tumor control and systemic chemotherapy may minimize the risk of metastasis.…”

“…Removal of the adjacent bone was attempted in recurrent tumors. 18,20 Radical surgery involving orbital bone resection was not routinely performed due to the high risk of meningitis and death. 1 Murray and colleagues proposed cranio-orbital resection for primary orbital disease.…”

“…17 Radical orbital exenteration has failed to demonstrate a benefit over conservative eye-sparing procedures in improving the outcome. 8,10,18,22 Because of these well-known limitations of surgical modalities, postoperative adjuvant EBRT was advocated to potentially reduce the risk of local tumor recurrence. 17,22 Despite surgery and EBRT, systemic prognosis of these patients remains grim, with survival of ≤50% at 5 years and 20% at 10 years.…”

Past, present, and future surgical management of malignant epithelial neoplasms of the lacrimal gland.

“…1). 4 At the time of their report this surgical procedure had been used on five patients with lacrimal gland neoplasms. Two of these five cases were adenoid cystic carcinomas.…”