Bone Regeneration of a 3D-Printed Alloplastic and Particulate Xenogenic Graft with rhBMP-2

Ryu, Ji-In; Yang, Byoung-Eun; Yi, Sang-Min; Choi, Hyo Geun; On, Sung-Woon; Lim, Ho-Kyung; Byun, Soo-Hwan

doi:10.3390/ijms222212518

Cited by 8 publications

(3 citation statements)

References 50 publications

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“…In seven articles, the matrix of the experimental group contained bone morphogenetic protein-2 (BMP-2) [ 28 , 42 , 45 , 49 , 88 , 89 ]. Bone regeneration was superior in all experimental groups, with the exception of three articles [ 90 , 91 , 92 ], which found similar values between the control and experimental group. Regarding secondary outcomes, Van Hede et al [ 73 ] analyzed matrix geometry, and found that the gyroid geometry results in better outcomes when compared to the orthogonal one.…”

Section: Resultsmentioning

confidence: 83%

Three-Dimensional Impression of Biomaterials for Alveolar Graft: Scoping Review

Francisco

Basílio

Ribeiro

et al. 2023

JFB

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Craniofacial bone defects are one of the biggest clinical challenges in regenerative medicine, with secondary autologous bone grafting being the gold-standard technique. The development of new three-dimensional matrices intends to overcome the disadvantages of the gold-standard method. The aim of this paper is to put forth an in-depth review regarding the clinical efficiency of available 3D printed biomaterials for the correction of alveolar bone defects. A survey was carried out using the following databases: PubMed via Medline, Cochrane Library, Scopus, Web of Science, EMBASE, and gray literature. The inclusion criteria applied were the following: in vitro, in vivo, ex vivo, and clinical studies; and studies that assessed bone regeneration resorting to 3D printed biomaterials. The risk of bias of the in vitro and in vivo studies was performed using the guidelines for the reporting of pre-clinical studies on dental materials by Faggion Jr and the SYRCLE risk of bias tool, respectively. In total, 92 publications were included in the final sample. The most reported three-dimensional biomaterials were the PCL matrix, β-TCP matrix, and hydroxyapatite matrix. These biomaterials can be combined with different polymers and bioactive molecules such as rBMP-2. Most of the included studies had a high risk of bias. Despite the advances in the research on new three-dimensionally printed biomaterials in bone regeneration, the existing results are not sufficient to justify the application of these biomaterials in routine clinical practice.

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Section: Resultsmentioning

confidence: 83%

Three-Dimensional Impression of Biomaterials for Alveolar Graft: Scoping Review

Francisco

Basílio

Ribeiro

et al. 2023

JFB

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“…Previous studies have reported that scaffolds fabricated with varying proportions of HA and β-TCP can effectively stimulate stem cell differentiation into osteogenic lineages and facilitate fresh osseous tissue generation. − These scaffolds align with the natural processes of bone regeneration and reconstruction. , Herein, we used ALP and alizarin red staining to show that SHSS can help enhance ALP expression and calcium nodule formation in BMSCs, indicating that it can help in the early and late stages of bone cell differentiation. Additionally, we observed a gradual increase in the mRNA expression levels of the Col-1 , OCN , and OPN genes at various time points (3, 7, and 10 days) during the osteogenic differentiation of BMSCs.…”

Section: Discussionmentioning

confidence: 91%

Three-Dimensional-Printed Spherical Hollow Structural Scaffolds for Guiding Critical-Sized Bone Regeneration

Liu,

Gao,

Liu

et al. 2024

ACS Biomater. Sci. Eng.

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The treatment of bone tissue defects continues to be a complex medical issue. Recently, three-dimensional (3D)printed scaffold technology for bone tissue engineering (BTE) has emerged as an important therapeutic approach for bone defect repair. Despite the potential of BTE scaffolds to contribute to long-term bone reconstruction, there are certain challenges associated with it including the impediment of bone growth within the scaffolds and vascular infiltration. These difficulties can be resolved by using scaffold structural modification strategies that can effectively guide bone regeneration. This study involved the preparation of biphasic calcium phosphate spherical hollow structural scaffolds (SHSS) with varying pore sizes using 3D printing (photopolymerized via digital light processing). The chemical compositions, microscopic morphologies, mechanical properties, biocompatibilities, osteogenic properties, and impact on repairing critical-sized bone defects of SHSS were assessed through characterization analyses, in vitro cytological assays, and in vivo biological experiments. The results revealed the biomimetic properties of SHSS and their favorable biocompatibility. The scaffolds stimulated cell adhesion, proliferation, differentiation, and migration and facilitated the expression of osteogenic genes and proteins, including Col-1, OCN, and OPN. Furthermore, they could effectively repair a critical-sized bone defect in a rabbit femoral condyle by establishing an osteogenic platform and guiding bone regeneration in the defect region. This innovative strategy presents a novel therapeutic approach for assessing critical-sized bone defects.

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“…In a recent study, a 3D-printed calcium phosphate scaffold was fabricated according to the geometry of artificial alveolar clefts in rats and showed promising scaffolding and osteoconductive properties ( Korn et al, 2020 ). A 3D-printed custom hydroxyapatite/TCP graft supplied with rhBMP2 also achieved bone regeneration to the same level of rhBMP2-coupled deproteinized bovine bone material (Bio-Oss ® ) ( Ryu et al, 2021 ). Although the exact mechanism of how 3D-printed scaffolds benefit orthodontic tooth movement remains unmapped, evidence suggests that grafting with 3D-printed scaffolds may offer enhanced orthodontic outcomes.…”

Section: Materials With 3d Printed Scaffoldsmentioning

confidence: 99%

Impact of Frontier Development of Alveolar Bone Grafting on Orthodontic Tooth Movement

Miao

Chang

Tanna

et al. 2022

Front. Bioeng. Biotechnol.

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Sufficient alveolar bone is a safeguard for achieving desired outcomes in orthodontic treatment. Moving a tooth into an alveolar bony defect may result in a periodontal defect or worse–tooth loss. Therefore, when facing a pathologic situation such as periodontal bone loss, alveolar clefts, long-term tooth loss, trauma, and thin phenotype, bone grafting is often necessary to augment bone for orthodontic treatment purposes. Currently, diverse bone grafts are used in clinical practice, but no single grafting material shows absolutely superior results over the others. All available materials demonstrate pros and cons, most notably donor morbidity and adverse effects on orthodontic treatment. Here, we review newly developed graft materials that are still in the pre-clinical stage, as well as new combinations of existing materials, by highlighting their effects on alveolar bone regeneration and orthodontic tooth movement. In addition, novel manufacturing techniques, such as bioprinting, will be discussed. This mini-review article will provide state-of-the-art information to assist clinicians in selecting grafting material(s) that enhance alveolar bone augmentation while avoiding unfavorable side effects during orthodontic treatment.

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Bone Regeneration of a 3D-Printed Alloplastic and Particulate Xenogenic Graft with rhBMP-2

Cited by 8 publications

References 50 publications

Three-Dimensional Impression of Biomaterials for Alveolar Graft: Scoping Review

Three-Dimensional Impression of Biomaterials for Alveolar Graft: Scoping Review

Three-Dimensional-Printed Spherical Hollow Structural Scaffolds for Guiding Critical-Sized Bone Regeneration

Impact of Frontier Development of Alveolar Bone Grafting on Orthodontic Tooth Movement

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