Bone, Periodontal and Dental Pulp Regeneration in Dentistry: A Systematic Scoping Review

Abstract

The aim of presented systematic scoping review was to investigate the actual and future clinical possibilities of regenerative therapies and their ability to regenerate bone, periodontal and pulp with histological confirmation of the nature of formed tissue. Electronic search was conducted using a combination between Keywords and MeSH terms in PubMed, Scopus, ISI-Web of Science and Cochrane library databases up to January 2016. Two reviewers conducted independently the papers judgment. Screened studies were read following the predetermined inclusion criteria. The included studies were evaluated in accordance with Arksey and O’Malley’s modified framework. From 1349 papers, 168 completed inclusion criteria. Several characterized and uncharacterized cells used in Cell Therapy have provided bone regeneration, demonstrating bone gain in quantity and quality, even as accelerators for bone and periodontal regeneration. Synthetic and natural scaffolds presented good cell maintenance, however polyglycolid-polylactid presented faster resorption and consequently poor bone gain. The Growth Factor-Mediated Therapy was able to regenerate bone and all features of a periodontal tissue in bone defects. Teeth submitted to Revascularization presented an increase of length and width of root canal. However, formed tissues not seem able to deposit dentin, characterizing a repaired tissue. Both PRP and PRF presented benefits when applied in regenerative therapies as natural scaffolds. Therefore, most studies that applied regenerative therapies have provided promising results being possible to regenerate bone and periodontal tissue with histological confirmation. However, pulp regeneration was not reported. These results should be interpreted with caution due to the short follow-up periods.

Hydroxyapatite Synthesis and Covering of Titanium Surfaces by Dip-Coating Method

“…Thick or irregular coating layers might modify the surface roughness and consequently produce heterogeneous textures. Irregular films are not desirable since could negatively interfere with cell adherence, differentiation, and consequently, on osseointegration [26,33,35,36].…”

Current status and future of delivery systems for prevention and treatment of infections in the oral cavity

“…Most of these polymers also exert adhesive properties which enables a longer retention of the system on application site. Hydrogels have found applications in dentistry for regenerative therapies to provide recovery of the function of tissues lost due to oral and dental pathologies of infection as well as traumatic and neoplastic origin [82][83][84]. Furthermore, various hydrogel formulations have been used for treatment of oral lesions and also for delivery of antimicrobials, anesthetics, and antiinflammatory drugs [85][86][87][88][89][90][91].…”

Functional roles of fish collagen peptides on bone regeneration

“…In the past decade, tremendous progress has been made toward the regeneration of dentin, dental pulp and periodontal tissues including alveolar bone and periodontal ligament in the field of dental tissue engineering, giving rise to the new field of regenerative dentistry [92][93][94][95][96][97] . FCP promotes matrix mineralization by positive effects on collagen synthesis and quality in osteoblasts.…”